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    Is mean platelet volume a predictor of atherosclerosis in hemodialysis patients?
    (2017) Yayar, Özlem; Eser, Baris; Bicakci, Fahrettin; Ayli, Mehmet Deniz
    Aim: Cardiovascular (CV) mortality accounts for the 45% of all mortality in dialysis. Carotid intima-media thickness (CIMT) is a preclinical marker for CV disease. Activated platelets pose important part of the cellular component in the pathophysiology of atherothrombosis. Mean platelet volume (MPV) is a parameter that indicates the activation of platelets and assessed by studies in various patient groups in atherosclerosis. The aim of this study is to determine the relation of MPV with CIMT in haemodialysis (HD) patients without a history of atherosclerosis. Material and Methods: Eighty two HD patients and 20 healthy individuals were enrolled in this cross-sectional study. Ultrasonographical B-mode imaging of bilateral carotid arteries was performed with a high resolution real-time ultrasonography with 12MHz linearassay transducer (Mindray DC7). The value was expressed as an average of the maximal CIMT. MPV was measured by automated devices. Results: CIMT was found to be higher in study population when compared to control group. MPV was not different between groups (8.40±0.85 vs 8.4±0.81; P>0.05). In correlation analysis CIMT was found to be positively correlated with age(r=0.326; P=0.003), ALP(r=0.309; P=0.005) and MPV(r=0.26; p= 0,017). Patients were grouped according to median levels of MPV. The patients having higher MPV values were found to have higher PTH (533.9 ± 458.3 vs 845.8 ± 860.2; P<0, 05) and CIMT (0.8 ± 0.1 vs 0.9 ± 0.2; P<0. 05) values. Conclusions: MPV was found to be correlated with CIMT in HD patients. MPV can be used as a marker in HD patients for determining atherosclerosis.
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    Usefulness of mean platelet volume as a biomarker for diagnosing arterivenosus fistulas thrombosis in routine hemodialysis patients
    (2020) Bilican, Gulden; Gok Oguz, Ebru; Ergin, Mustafa; Yayar, Ozlem; Kivrakoglu, Fatih; Oztekin, Sanem; Ayli, Mehmet Deniz; Sahin, Hatice
    Aim: Hemodialysis patients should have an access to a vessel. Thrombosis is responsible for 80-85% of fistula losses. Mean Platelet Volume (MPV) is routinely measured in complete blood count and shows the average volume of circulating platelets. In our study, we aimed to investigate whether MPV values may be used as a cheap and noninvasive marker in the early diagnosis and intervention of arteriovenous fistula (AVF) thrombosis.Material and Methods: This retrospective study included 48 patients having one or more episodes of late fistula thrombosis at the hemodialysis unit and 47 patients without history of AVF thrombosis.Results: Demographic and laboratory characteristics were used to compare between groups and no significant difference was found (p> 0.05). On the other hand, significant difference was reported (p=0.001) by the comparison of two groups. Logistic regression analysis, revealed that MPV was an independent risk predictor for the development of AVF thrombosis (p 0.05).Conclusion: AVF dysfunction leads to a significant cost and frequent hospitalization of the patient. Previously, MPV was stated to be a risk factor for arterial and venous thrombosis. This study showed that MPV values may be used in hemodialysis patients as a predictor of thrombosis. Further prospective and retrospective studies should be conducted in order to verify the finding of this study.