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Öğe Orthopedic trauma or surgery does not effect on cognitive or behavioral capability of rats(2020) Aytekin, Kursad; Uysal, MuratAim: The aim of this study is to investigate the probable effects of orthopedic trauma/surgery on anxiety, memory and learning capability in rats. Material and Methods: Twenty-one Wistar albino rats grouped into three as control, sham operated, and tibia fracture. In control group, any surgery or fracture was done whereas in sham group the tibia of rats was fixed with intramedullar Kischner wire. In tibia fracture group, a closed fracture was occurred with Bonnarens and Einhorn's guillotine device then intramedullar Kischner wire sends to tibia. All rats were evaluated for memory, anxiety, and learning via behavioral tests respectively; water-maze test, elevated plus arm test and shuttle box test. Results: One month after the fractures were done and the bone healing was seen on X-ray at all rats. According to the behavioral tests results, there was not any statistically difference between groups in terms of anxiety, learning capability, locomotor activity and memory (p>0.05). Conclusion: Our results showed that, the orthopedic trauma or surgery itself does not affect the anxiety, learning capability, locomotor activity and memory in rats.Öğe Results of percutaneous needle culture sampling and synchronous irrigation with Dakins' solution in Wagner Grade 3 diabetic foot osteomyelitis(Nature Portfolio, 2026) Aytekin, Feyza Yildiz; Takir, Selcuk; Gurbuz, Perihan; Agraz, Melih; Aytekin, KursadWagner Grade 3 diabetic foot osteomyelitis is a severe infection involving bone, often requiring a multidisciplinary approach for effective management. While percutaneous bone biopsy is widely recognized as the gold standard for pathogen identification, the addition of percutaneous bactericidal irrigation has not been extensively explored in the literature. This study evaluates a minimally invasive approach combining percutaneous needle culture sampling with Dakins' solution irrigation in a single session. A retrospective analysis of 31 patients was conducted to assess its feasibility, effectiveness in pathogen identification, and impact on infection control. The most frequently isolated bacterium was Staphylococcus aureus, with no significant correlation between bacterial type and infected bone. Four patients required re-intervention due to persistent symptoms, revealing different bacterial isolates upon re-culture. Significant reductions in CRP levels were observed post-intervention, while WBC changes were not statistically significant. These findings suggest that this combined percutaneous approach may be an effective and minimally invasive strategy for both diagnostic and therapeutic purposes in Wagner Grade 3 osteomyelitis. Further studies with larger sample sizes and extended follow-up are warranted to confirm its long-term benefits.











