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    CERVICAL PREGNANCY - CAN AGE AND PARITY BE PREDISPOSING FACTORS
    (Munksgaard Int Publ Ltd, 1994) SONMEZ, AS; KAFKASLI, A; BALAT, O; SARAC, K; URYAN, I; TURHAN, O; AYDIN, NE
    A fifty-year old woman, gravida 17, para 17, presented with profuse vaginal bleeding following curettage in another hospital. At emergency laparotomy total abdominal hysterectomy and bilateral salpingooopherectomy was performed because of intractable hemorrhage. Histopathologic examination revealed endocervical placentation and adenomyosis uteri. The case is presented due to its rarity and possible predisposing factors are discussed.
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    A TRIAL OF LOBAPLATIN (D-19466) IN PLATINUM-RESISTANT OVARIAN-CANCER
    (Academic Press Inc Elsevier Science, 1995) KAVANAGH, JJ; EDWARDS, CL; FREEDMAN, RS; FINNEGAN, MB; BALAT, O; TRESUKOSOL, D; BURK, K
    Long-term survival in epithelial ovarian cancer remains problematic despite multimodality therapy, A fundamental difficulty is the development of tumor resistance to platinum compounds, Analogs have been developed that demonstrate activity in platinum-resistant cell lines both in vitro and in vivo. Lobaplatin (D-19466), a third-generation compound, demonstrates significant activity in carboplatin and cisplatin-resistant cell lines, Lobaplatin was given to 17 assessable patients with platinum-refractory ovarian cancer. The drug was initially administered at a dose of 50 mg/m(2) but was later reduced to 40 mg/m(2) because of excessive thrombocytopenia, Nine patients required red cell transfusions during therapy, Cycles were repeated every 21-35 days (median cycle length 28 days), No objective responses were observed, Lobaplatin has no activity in platinum-resistant epithelial ovarian cancer. (C) 1995 Academic Press, Inc.