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  • Küçük Resim Yok
    Öğe
    Evaluation of systemic tissue involvement in mice following intraperitoneal inoculation of Toxoplasma gondii RH Ankara strain
    (Refik Saydam National Public Health Agency (RSNPHA), 2015) Şamdancı Türkmen, Emine; Taylan Özkan, Ayşegül; Babür, Cahit; Mungan, Mesut; Aydın, Engin
    Objective: This study aimed to pathologically evaluate systemic tissue involvement in acute toxoplasmosis in mice inoculated with Toxoplasma gondii RH Ankara strain. Method: Forty-two Mus musculus albino mice were divided into four groups with the control group receiving no inoculation, the group consisting of mice that were not sacrificed after intraperitoneal inoculation and the groups consisting of mice euthanasia were performed on day runner up or day fourth following intraperitoneal inoculation. A 48-50-hour intraperitoneal passage of T. gondii RH Ankara strain in mice was used for inoculation and each mouse received 5×104 tachyzoites. The mice sacrificed by euthanasia were macroscopically examined and then collected tissue samples fixed in 10% formalin. The preparations set by from the tissues blocked in paraffin were stained with hematoxylin-eosin and histopathological examination was performed. Results: Necrosis in the serosa of the intestine and parenchyma of the liver, spleen, kidneys, pancreases and omentum and many free groups of tachyzoites were observed. Tachyzoites were identified in alveolar capillary lumens in the lungs. No pathological finding was observed in the cerebrum and cerebellum but few tachyzoites. It was observed that tissue necrosis and the density of Toxoplasma gondii tachyzoites were directly proportional to the duration of post inoculation. All infected mice that received no intervention died on day sixth. In this study in mice, it was found that T. gondii RH Ankara strain induced the same pathological findings as the RH strain belonging to the virulent Type I group. Conclusion: Mice inoculation can be used for diagnosis and this model may also be used in studies investigating vaccination, drugs and pathogenesis.
  • Küçük Resim
    Öğe
    Malatya ilinde belediyede çalışan temizlik işçilerinin toxoplasmosis ve listeriosis seropozitifliği yönünden değerlendirilmesi
    (Türk Hijyen ve Deneysel Biyoloji Dergisi, 2008) Çelik, Turgay; Karaman, Ülkü; Çelebi, Bekir; Turan, Ayşe; Babür, Cahit; Daldal, Nilgün
    ABSTRACT Objective: Method: Results: Conclusion: Key Words: A . Ülkemizde de görülen listeriosis ve toxoplasmosis bölgenin coğrafik konumuna, sosyokültürel yapısına ve beslenme şekline göre farklı oranlarda görülmektedir. Çalışmada Malatya ili merkez belediyesinde zoonoz hastalıkları açısından risk grubu olduğu düşünülen 150 temizlik personelinde listeriosis ve toxoplasmosis seroprevalansının saptanması amaçlanmıştır. Araştırmada listeriosis tanısı için Aglütinasyon Yöntemi ve toksoplazmosis tanısı için Sabin Feldman Dye Testi kullanılmıştır. Yapılan değerlendirmede çalışan 150 personelin 14 (%16)'ünde Listeriosis ve 37'sinde (%24,6) anti- antikoru tespit edilmiştir. ntikor titreleri açısından da listeriosisde çöp toplayıcı ve süpürgecilerde seropozitiflik yüzdesi yüksek bulunmuştur. Toxoplasmosisde de süpürgeci olarak çalışanlarda seropozitiflik diğer gruplara göre yüksektir. Risk grubunu oluşturan meslek çalışanlarına zoonotik enfeksiyonlarla ilgili bilgilendirme, bulaşma ve korunma yolları yönünden halk sağlığı eğitim programlarının uygulatılması ve bölgede bu enfeksiyonların epidemiyolojik özelliklerinin aydınlatılması için daha ileri araştırmaların yapılması gerektiği sonucuna varılmıştır. Belediye işçileri, listeriosis, toxoplasmosis The prevalence of listeriosis and toxoplasmosis in Turkey varies according to the geography, socio-cultural profile, and dominant nutrition habits of the region. The purpose of the present study is to determine the listeriosis and toxoplasmosis seroprevalence among 150 dustmen working in Malatya municipality who are considered to be a risk group in terms of zoonotic diseases. Agglutination test and Sabin Feldman dye test were used to determine listeriosis and Toxoplasmosis, respectively. The evaluation revealed that out of 150 dustmen 14 (16 %) were infected with Listeriosis and 37 (24.6 %) with anti- antigen. The rate of seropositivity for listeriosis among garbage collectors and sweepers was found to be high. The seropositivity for toxoplasmosis among sweepers was also higher than the other groups Finally, it was concluded that the workers in this risk group should be informed about zoonotic infections, given some public health training programs about the ways of contagion and protection, and further researches should be carried out for better clarification of the epidemiology of such infections. Dustmen working, listeriosis, toxoplasmosis