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    Immobilization of Xylanase on ZnO nanoparticles obtained by green synthesis from Eupatorium cannabinum L. and its application in enrichment of fruit juices
    (Elsevier B.V., 2024) Selçuk Pekdemir S.; Bakar B.; Taş R.; Ulu A.; Pekdemir M.E.; Ateş B.
    Juice production is one of the main components of the nutritional food industry. Therefore, improving fruit juice quality and preventing the formation of negative by-products is important for human health. The role of environmentally friendly, safe and economically more affordable green nanocarriers in improving the quality of fruit juice is increasing day by day. For this purpose, zinc oxide nanoparticles (ZnONPs) were prepared from the aqueous extract of the Eupatorium cannabinum L. using the green synthesis method. After immobilization, structural and morphological characterizations of the prepared ZnONPs and xylanase (Xyl)@ZnONPs were carried out, which confirmed that both the synthesis of ZnONPs and the immobilization of Xyl enzyme on ZnONPs were successfully carried out. The biochemical parameters of Xyl@ZnONPs such as optimum pH and temperature, kinetic parameters, thermal stability, reusability, and storage stability were investigated and compared with free Xyl. After immobilization, the optimum pH of free Xyl shifted from 5.0 to an alkaline pH of 8.0, while no change in the optimum temperature (70 °C) was observed for both enzymes. While the activation energy of free Xyl was 5.56 kJ/mol, it was found to be 7.27 kJ/mol for Xyl@ZnONPs. Xyl@ZnONPs outperformed free Xyl due to its long-term storage stability and reusability. Moreover, Xyl@ZnONPs retained 50 % of its activity after 5 reuses and 87 % of its activity after 4 weeks of storage at room temperature. In addition, a decrease in Km value and an increase in Vmax value were observed after immobilization, which means the increased catalytic activity of the Xyl@ZnONPs. As a result of re-using Xyl@ZnONPs in orange juice for 6 cycles, clarification yield of 66.43 % was obtained under optimized conditions. Overall, this study prepared a suitable, environmentally friendly, and robust carrier support for Xyl immobilization and developed a biocatalyst that will provide high performance in the industrial field. © 2024 Elsevier B.V.
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    Long-Term Effects of Tinnitus and Vertigo Symptoms on Quality of Life in Patients with Idiopathic Sudden Sensorineural Hearing Loss
    (Turkiye Klinikleri, 2023) Cengiz D.U.; Özdemir E.A.; Arik H.; Bakar B.; Nur N.; Demir İ.
    Objective: To determine the effect of tinnitus and vertigo symptoms on quality of life in the long term after medical treatment in individuals with idiopathic sudden sensorineural hearing loss. Material and Methods: The study included 18-65 years old 63 patients (20 women-43 men) who were diagnosed with idiopathic sudden hearing loss at Ear Nose and Throat Diseases Polyclinic of İnönü University Turgut Özal Medical Center and had at least 20 dB HL improvement in the mean pure tone threshold as a result of the medical treatment. A Demographic Data Form, the Dizziness Handicap Inventory, the Tinnitus Handicap Inventory, and the Multidimensional Index of Life Quality were administered to all participants. The patients were assigned into two groups as those with dizziness and tinnitus symptoms (n=33) and those without symptoms (n=30). Results: No statistically significant difference was found between the symptomatic and nonsymptomatic groups according to age, time from diagnosis and gender (p>0.05). The groups show a homogeneous distribution according to age, time since diagnosis and gender. Index of Life Quality Scale physical health scores, mental health scores, interpersonal relations scores, and total score were significantly higher in the non-symptomatic group than in the symptomatic group (p<0.05). There was no statistically significant difference between the two groups in terms of access to health personnel scores, financial status scores, and social function scores (p>0.05). Conclusion: Although there was an improvement in hearing thresholds after treatment in individuals with idiopathic sudden sensorineural hearing loss, tinnitus and vertigo symptoms could persist in the long term and these symptoms had a serious negative impact on the individual's quality of life. These individuals should be followed up after treatment and holistic evaluations should be made with audiovestibular tests. The quality of life of individuals can be increased by applying appropriate treatment/rehabilitation with a multidisciplinary approach. © 2022 Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. Production and hosting by Türkiye Klinikleri.