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  • Küçük Resim
    Öğe
    Basit Nefrektomi Sonrası İnsidental Olarak Saptanan Primer Renal Oteosarkom ve Ksantogranülomatöz Piyelonefrit Olgusu
    (2013) Güvel, Sezgin; Bal, Nebil
    Öz:Primer renal osteosarkom çok nadir görülen bir tümördür. Bugüne kadar literatürde sadece 21 olgu rapor edilmiştir. Bu hastalığın tedavisinde cerrahi, polikemoterapi ve radyoterapi gibi farklı seçenekler olmasına karşın ideal tedavi konusundaki bilgiler halen tatmin edici düzeyde değildir. Tüm tedavi seçeneklerine rağmen tümör oldukça hızlı seyirli ve kötü prognoz özelliklerine sahiptir. Literatürde bildirilen olguların yaşam süreleri 8 ile 22 ay arasında değişmektedir. Biz de bu makalede taşlı nonfonksiyone böbrek nedeni ile basit nefrektomi yapılan ve patolojik incelemede renal osteosarkom ve ksantogranülamatöz piyelonefrit bulunan 56 yaşında bir erkek hasta sunmuş bulunmaktayız. Bu hasta ürolitiyazis ve ksantogranülomatöz piyelonefritle birlikteliği açısından literatürde bildirilen ilk primer renal osteosarkom olgusudur.
  • Küçük Resim Yok
    Öğe
    Comparison of Cajal-like cells in pelvis and proximal ureter of kidney with and without hydronephrosis
    (Brazilian Soc Urol, 2015) Balikci, Omer; Turunc, Tahsin; Bal, Nebil; Celik, Huseyin; Ozkardes, Hakan
    Objectives: To evaluate effects of Cajal-like cells on human renal pelvis and proximal ureter on peristalsis. Materials and Methods: 63 patients submitted to nephrectomy due to atrophic non- functional kidney associated with hydroureteronephrosis were included as study group and 30 cases with nephrectomy due to other reasons were included as control group. Samples from renal pelvis and proximal ureters were obtained and sections of 5 mu form paraffin blocks of these samples were prepared; layers of lamina propria and muscularis mucosa were examined by immune-histochemistry using CD117 in order to determine count and distribution of Cajal-like cells. Results: During immune-histochemical examinations of sections, obtained from renal pelvis and proximal ureter of hydronephrotic kidneys by CD117, Cajal-like cells number determined in lamina propria and muscularis propria was statistically significantly lower compared to control group (p<0.001). Distribution of Cajal-like cells in renal pelvis and proximal tubulus was similar under examination by light microscope, and also both groups were not different from each other regarding staining intensity of Cajal-like cells by c-kit. Conclusion: Significantly reduced number of Cajal-like cells in study group compared to control group, shows that these cells may have a key role in regulation of peristalsis at level of renal pelvis and proximal ureter in urinary system.
  • Küçük Resim
    Öğe
    Expression of maspin in testis tumors with germ cells and its relation with angiogenesis factors
    (2016) Çelik, Hüseyin; Turunç, Tahsin; Bal, Nebil; Hasırcı, Eray; Akay, Alaaddin; Peşkircioğlu, Çetin Levent
    Abstract: Background/aim: We aimed to evaluate the importance of maspin expression in testicular tumors with germ cells, its effect on prognosis, and the relation with angiogenesis factors. Materials and methods: The paraffin blocks of the orchiectomy materials of 32 patients who had undergone orchiectomy due to testicular tumors were taken within the scope of the study. The specimens of the cases included in the study group were reexamined under light microscope. Results: While just one maspin-positive sample was found in the seminoma cases, maspin stained positively in 6 of the nonseminoma germ cell tumors (NSGCTs). No statistical difference was found between maspin and tumor stage, size, alpha fetoprotein values, vascular endothelial growth factor, Ki-67, and CD31. A statistically positive correlation was only determined between maspin and p53 (P < 0.001). Conclusion: Maspin protein, whose expression in some tumors is accepted as a poor prognostic factor, is also expressed in testicular tumors with germ cells. However, according to our study, it is difficult to say whether this protein is a favorable or poor prognostic factor in testicular tumors and to understand how the effect mechanism works. The positive correlation between maspin and p53 in the NSGCTs makes us think that maspin might have displayed an effect on the p53 pathway.