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    The effect of periodontal treatment on depression, body image, self esteem and anxiety in individuals: A randomized controlled clinical trial
    (2021) Gokturk, Ozge; Inanir, Sema; Balci Yuce, Hatice; Demir, Osman; Aydemir Turkal, Humerya
    Aim: Depression is a multi-factorial disease characterized by a variety of symptoms. Individuals with psychiatric disorders are seem to be more prone to periodontitis. However, depression and periodontal disease can be considered bidirectional risk factors. Periodontal diseases can also be an effect on depression. The aim of this study is to determine the effect of non-surgical mechanical periodontal treatment on psychological state. Materials and Methods: Two randomized groups were established from depressed patients with non-treated periodontal diseases. Test (n = 92) and control group (n = 92). Clinical periodontal and psychological measures were administered at baseline and at 6 weeks in the control and test group. Periodontal treatment was applied to the test group. Results: After 6 weeks (the end of the periodontal therapy) there was a significant decrement in the results of Beck Depression Inventory (p a = 0.038) and a significant increment in Body Cathexis Scale (p a < 0.001) results in the test group. However, the results of Rosenberg Self-Esteem Scale (p a = 0.820) and Beck Anxiety Inventory (p a = 0.071) is similar between test and control groups. Conclusion: Within the limits of present study, the results suggest that periodontal treatment might be useful to improve depressive patients’ psychological conditions.
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    Evaluation of the effects of various agents on aggregatibacter actinomycetemcomitans, candida albicans, and streptococcus mutans growth
    (2019) Taskan, Mehmet Murat; Karaman, İsa; Balci Yuce, Hatice; Isiker Kara, Gozde
    Aim: Oral environment hosts many microorganisms and even symbiotic microorganisms can cause diseases under appropriate conditions and antimicrobial therapy might be required. The aim of the present study was to evaluate the effect of various antioxidants on Aggregatibacter actinomycetemcomitans, Candida albicans, and Streptococcus mutans as pathogenic microorganisms of the oral environment.Material and Methods: In present research, the antibacterial effects of various antioxidants on oral bacteria, Aggregatibacter actinomycetemcomitans (A.actinomycetemcomitans, ATCC 33384), Streptococcus mutans (S.mutans, ATCC 35668), and fungus Candida albicans (C.albicans, ATCC 90819) were tested. The tested antioxidants were curcumin, gallic acid, and vanillic acid. The concentrations of the antioxidants were adjusted to 5% and appropriate solvents were used for the agents. The solvents were distilled water for gallic acid, ethanol for vanillic acid and dimethyl sulphoxide (DMSO) for curcumin. Antibiotics ciprofloxacin, penicillin, tetracycline, and chlorhexidine were used as positive control agents. The antibacterial effect of the antioxidants were tested with disc-diffusion method.Results: Positive control agents provided significant antibacterial efficacy compared to the test agents and negative controls. The most significant effect was observed on ciprofloxacin against all tested microorganisms. On the other hand, penicillin provided similar effects with the chlorhexidine and tetracycline. All antioxidants tested in the present study was found ineffective against all tested microorganisms. Topical use of antioxidants did not provide efficacy. Conclusion: Antioxidants have significant effects on preventing oxidative stress and decreasing inflammation-driven pathologies. However, the tested antioxidants did not provide an antibacterial effect against A.actinomycetemcomitans, S.mutans, and C.albicans.
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    Growth behavior of eikenella corrodens and streptococcus gordonii in response to a short chain fatty acid metabolite-acetic acid
    (2017) Balci Yuce, Hatice; Tulu, Feyza; Inis, Sule; Karaman, Isa
    Aim: Periodontal diseases are chronic, inflammatory and infectious diseases. Therefore, periodontal treatment aims to eliminate periodontopathogenic bacteria causing periodontal diseases. The aim of present study was to evaluate the effect of a bacterial end metabolite, acetic acid, on periodontopathogenic bacteria, Streptococcus gordonii and Eikenella corrodens. Material and Method: In present research, Eikenella corrodens (ATCC® 23834™) and Streptococcus gordonii (NCTC 7870) were tested. Acetic acid was used in 5% concentration dissolved in distilled water. Negative control agent was distilled water and positive control agents were 0.012% chlorhexidine, penicillin, tetracycline and ciprofloxacin. The antibacterial efficacy of acetic acid against bacteria was tested via disc-diffusion method, MIC test and minimum bactericidal concentration tests. Results: The inhibition zone of ciprofloxacin, penicillin, tetracycline, CHX and acetic acid against Eikenella corrodens and Streptococcus gordonii were 32 and 37 mm, 16 and 14 mm, 21 and 16 mm, 13 and 17 mm, and 14 and 11 mm respectively. Ciprofloxacin and penicillin inhibited bacterial growth in MIC and MBC tests against both bacteria. MIC tests of acetic acid and chlorhexidine against Eikenella corrodens revealed inhibitory effect at 7.81 µl/mL and 0.97 µl/mL concentrations, respectively. Against Streptococcus gordonii, MIC of acetic acid and chlorhexidine were 1.95 µl/mL and 3.90 µl/mL, respectively. Conclusion: Acetic acid is a bacterial end product and has a daily consumption as vinegar. Due to the antibacterial efficacy against periodontopathogenic bacteria, it can be useful in adjunction to periodontal treatment. Further studies to evaluate clinical use of acetic acid as mouthwash, dentifrice, gel and/or irrigation agent are necessary.
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    Topical quercetin gel application improved wound healing in Wistar rats
    (2019) Taskan, Mehmet Murat; Balci Yuce, Hatice; Karatas, Ozkan; Gevrek, Fikret
    Aim: Quercetin is an antioxidant agent with proven beneficial effects in preventing inflammation. Aim of present study was to evaluate effects of quercetin gel on a secondary intention wound healing model in Wistar rats.Material and Methods: 42 Wistar rats were divided into two groups, one group administered quercetin gel (Q, n=18) while other administered vehicle (C, n=24). 5-mm diameter palatal wounds were created in each rat and all rats were given either quercetin gel or vehicle daily until sacrification days. Gel contained 5% quercetin, 5% benzocaine and glycerin, and each rat administered 0.2 ml of gel every day. Rats were sacrificed at 0th day, 7th day, 14th day, and 21st day. Fibroblast cell counts and inflammatory cell infiltration were evaluated on hematoxylin-eosin stained sections. Collagen type I and III were evaluated via immunohistochemistry.Results: Wound area decreased from day 0 to day 21 in both groups. Significant differences in wound contraction and unhealed wound area were observed between 7th and 21th days in both groups. Improvement in wound area in morphological measurements was similar in both quercetin and control groups except for 21st day on which quercetin exhibited higher wound closure. Histological findings showed significantly higher fibroblast cell counts on 7th, 14th, and 21st days in the quercetin group and difference in both quercetin. Inflammatory cell counts significantly decreased from day 0 to 21 in both groups. Collagen I synthesis were lowest on the 0th day and significantly increased on all other times in both groups. As for collagen III, the levels were highest on 7th day in both groups and significantly decreased on the 14th and 21st day. Conclusion: Present results revealed an improvement in wound healing after quercetin administration which was indicated by decreased inflammatory cells and increased fibroblast cells. However, collagen synthesis was found similar.