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    Chemical composition and biological activities of essential oil of Thymus haussknechtii Velen. from Turkey
    (Chemical Publishing Co., 2016) Arabaci T.; Özgül O.; Içen M.S.; Açari I.K.; Balcioglu S.; Gürhan I.
    The genus Thymus L. is represented by 40 species (42 taxa) in Turkey, of which 18 are endemic. Thymus haussknechtii Velen. is endemic species of the genus. In this study, the essential oil of Thymus haussknechtii, obtained by hydrodistillation from the aerial parts, were analyzed by GC/MS. The main constituents of the oils are identified and antioxidant and antibacterial bioassays were determined. Isoborneol (9.06 %), linalool (8.44 %), ?-pinene (6.45 %), ?-terpinene (6.08 %), camphene (5.12 %), caryophylleneoxide (5.11 %) are established as the major components of the essential oil. The antibacterial activity was evaluated against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213. Both tested bacteria were inhibited by the essential oil. The essential oil of the species was subjected to a screening for their possible antioxidant activities by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS. A remarkable antioxidant activity was observed from the essential oil according to the comparison with the antioxidative potentials of the standard compound used in this study. The findings of the analyzed taxa are compared with the results of previous studies.
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    Synthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman’s Syndrome) after Surgical Injury
    (American Chemical Society, 2024) Aksoy Erden B.; Kurus M.; Turkcuoglu I.; Melekoglu R.; Balcioglu S.; Yigitcan B.; Ates B.
    Asherman’s syndrome, which can occur during the regeneration of damaged uterine tissue after surgical interventions, is a significant health problem in women. This study aimed to acquire and characterize cyclodextrin-based hydrogels, which can be used to prevent Asherman’s syndrome, and investigate their effectiveness with biomedical applications. A series of hydrogels were synthesized from the cross-linking of ?-cyclodextrin and different polyphenols with epoxy-functional PEG. Their chemical, physical, and biological properties were subsequently determined. The results demonstrated that the cyclodextrin-based hydrogels had a porous structure, high swelling ratio, good injectability, drug release ability, and antioxidant activity. Cell culture results illustrated that the hydrogels had no significant cytotoxicity toward L929 fibroblast cells. Considering all properties, the ?-CD-PEG-600-Ec hydrogel showed the most satisfactory properties rather than other ones. The potential of this hydrogel in preventing Asherman’s syndrome was evaluated in a rat model. The results revealed that the ?-estradiol- and melatonin-loaded cyclodextrin-based multifunctional hydrogel group both structurally and mechanically showed an antiadhesion effect in the uterus and a therapeutic effect on the damage with the ?-estradiol and melatonin that it contains compared to the Asherman (ASH) group. This double drug-loaded hydrogel can be a promising candidate for preventing Asherman’s syndrome due to its versatile properties. © 2024 The Authors. Published by American Chemical Society.