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    Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy
    (Acta Cirurgica Brasileira, 2018) Gozeneli, Orhan; Tatli, Faik; Gunes, Ali Erdal; Guldur, Muhammed Emin; Taskin, Abdullah; Bardakci, Osman; Yilmaz, Mehmet
    Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver. Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis. Results: Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3. Conclusions: Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin.
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    A new seton tightening method for anal fistula treatment: sailor's knot
    (Edizioni Luigi Pozzi, 2021) Tatli, Faik; Bardakci, Osman; Ozgonul, Abdullah; Erkmen, Firat; Karaca, Emre; Erol, Mehmet Kenan; Yilmaz, Mehmet
    AIM: There are certain problems experienced while retightening the seton material during the patient follow-ups, such as pain and anaesthesia requirements in perianal fistula. The aim of the present study was to compare a sailor's knot with other seton tightening methods for the surgical treatment of perianal fistulas. MATERIAL AND METHODS: The records of 105 patients who underwent surgeries for perianal fistulas using the seton method between 2016 and 2019 were analysed retrospectively. The demographic characteristics, complaints, fistula localizations, surgery types, hospital stay lengths, postoperative complications and imaging modalities of the patients included in the study were recorded. The patients were divided into two groups according to the surgical treatment method. Those patients who underwent seton procedures with a sailor's knot were included in Group 1. Group 2 included those patients who underwent other seton procedures, including silk and penrose drain procedures. Groups were compared with regard to success rates and postoperative recurrence. RESULTS: There was no statistically significant difference between the groups in terms of the age, gender, fistula type and follow-up duration. Success rate in all patient was 88.6%, 91.2% in group 1 and 87.1% in group 2 (p=0.36). The number of patients with a kind of incontinence was 7 (7.1%), 3 (5.8%) in Group 1 and 4 (7.4%) in Group 2 (p = 0.297). CONCLUSION: There were no statistically significant differences with regard to complications and recurrences between the sailor's knot and the other seton tightening methods used for the treatment of anal fistulas. The sailor's knot is recommended with regard to its easy application and seton retightening with satisfactory outcomes.
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    Single center experience in perianal fistula surgery
    (2018) Tatli, Faik; Ozgonul, Abdullah; Ciftci, Resit; Gumer; Mehmet; Erkmen, Firat; Karaca, Emre; Bardakci, Osman
    Aim: Perianal Fistula is the chronic stage of anorectal infection and is characterized by intermittent pain associated with purulent drainage or abscess formation followed by spontaneous abscess drainage. In this study, we aimed to investigate the recurrence rates according to the type of surgery performed for patients who underwent surgery for perianal fistula. Material and Methods: The records of 201 patients who underwent surgery in our hospital between the dates of January 2015 and May 2018 were analyzed retrospectively. In addition to the demographic information of the patients included in the study, their complaints, localization of the fistula, type of surgery performed, length of stay in the hospital, postoperative complications, and imaging methods were recorded. Loose or incisional seton stitch, fistulotomy and fistulectomy were performed according to the localization and the type of fistula. The seton stitch method was applied to complex fistulas, and the fistulotomy and fistulectomy methods were applied to simple fistulas. Results: Of the patients included in the study, 178 (88.5%) were males and 23 (11.5%) were females. Their mean age was 41.65 (27-77) years. Of the patients, 136 (67.7%) had complex and 65 (32.3%) had simple fistulas. The fistulas were intersphincteric in 90 (44,8%) patients, transsphincteric in 51 (25.4%) patients, suprasphincteric in 33 (16.4%) patients, and extrasphincteric in 27 (13.4%) patients. Conclusion: The complications and recurrence rates were found to be low postoperatively in all types of surgical procedures performed in our clinic. No statistically significant difference was found between the type of surgery and the recurrence rate.