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    Botulinum Neurotoxin-A therapy in patients with refractory overactive bladder
    (2020) Barut, Osman; Resim, Sefa
    Aim: The aim of this study was to evaluate the clinical efficacy and safety of intravesical botulinum neurotoxin-A injection in patients with refractory overactive bladder to conservative treatment and anti-muscarinic drugs.Material and Methods: The data of 62 patients, who received botulinum neurotoxin-A (BonTA) injection (100 U) for overactive bladder (OAB) between 2015 and 2019, were reviewed retrospectively. For 55 patients included into the study, the urinary frequency and urgency, the number of incontinence and nocturia episodes, the maximum flow rate (Qmax), the post-void residual volume (PVR), and the Urinary Incontinence Quality of Life (I-QoL) scores were evaluated before the treatment and at the third month after the treatment. Results: The comparison of the pre-treatment and posttreatment 3rd-month follow-up data revealed a statistically significant decrease in the urinary frequency and urgency, and the number of incontinence and nocturia episodes (p 0.05). The mean I-QoL score increased significantly in the posttreatment 3rd month compared to the pre-treatment scores (43.62 ± 11.2 and 75.2 ± 12.6, p = 0.001, respectively). After the treatment, hematuria developed in 3 female and 2 male patients and urinary tract infections developed in 4 females and 2 male patients.Conclusion: BonTA injection significantly improves the daily urinary frequency, incontinence, and quality of life scores in patients with OAB.
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    Comparison of access tecniques in treatment of renal stones with percutaneous nephrolithotomy
    (2019) Barut, Osman; Resim, Sefa
    Aim: A proper percutaneous renal access is the most crucial step in the procedure. This retrospective study aims to compare the efficacy and safety of monoplanar and biplanar access in PCNL operations.Material and Methods: The study included a total of 72 patients with single kidney stones larger than 20 mm in diameter, who underwent PCNL surgery between September 2016 and May 2018. The patients were divided into two groups monoplanar access (Group 1) and biplanar access group (Group 2). There were 38 and 34 patients in Groups 1 and 2, respectively. Stone and urinary system characteristics, operation parameters and postoperative findings of all patients were recorded.Results: There was no statistically significant difference between two groups in terms of mean age, sex and kidney stone size. Mean operation duration was 64.3 ± 21.7 minutes in group 1 and 61.8 ± 27.4 minutes in group 2 (p=0.494). A statistically significant difference was observed between the groups in terms of mean fluoroscopy time, which was 3.46±1.24 minutes in group 1 and 4.45±1.57 in group 2 (p=0.008). The mean puncture time was significantly lower in group 1 (p=0.042). The stone-free rate was 78.9% and 82.3% in groups 1 and 2, respectively (p=0.87). There was no statistically significant difference between the groups in terms of complications (p=0.72). Conclusion: Both access techniques have been found to similar success and complication rates in PCNL operations. However, the fluoroscopy duration and puncture time are shorter in cases where monoplanar access is established; which may be effective in preferring this technique.

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