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Öğe Assessment of Hepatic Steatosis Using Clinical and Laboratory Parameters with Computed Tomography Comparison in Living Liver Donor Candidates(2023) Sarıgöz, Talha; Baskiran, Deniz YavuzObjective: Hepatic steatosis (HS) is a critical element in evaluation of living liver donor can- didates (LLDC). We aimed to find predictors of HS while correlating computed tomography (CT) based attenuation assessments with clinical parameters of LLDC. Methods: A total of 524 LLDC were included in the study. From those, 227 of them were declined due to HS detected by CT and 297 of them underwent successful donation process. These two groups were evaluated statistically in terms of CT based liver attenuation indices, clinical and laboratory parameters to find predictors of HS. Results: Other than low-density lipoprotein, neutrophil count, neutrophil/lymphocyte ra- tio, platelet distribution width, platelet count, and alpha fetoprotein, all of the laboratory parameters were different between the groups (p<0.05). The median liver attenuation value in accepted donors was 64 and in declined donors, it was 51 (p<0.001). Body mass index (BMI) had the highest diagnostic accuracy for HS followed by alanine aminotransferase (ALT). The cutoff value for BMI (72% sensitivity) was 26.3 kg/m 2 and it was 21 IU/L for ALT (69% sensitivity). Conclusion: BMI>26.3 and ALT>21 correlate well with HS and those subjects should be evaluated later if more appropriate donor candidate is present.Öğe Determination of COVID-19 Phobia Level in Health Care Workers(Routledge Journals, Taylor & Francis Ltd, 2022) Baskiran, Deniz Yavuz; Bayir, Berna; Pehlivan, ErkanThe aim of this study is to determine the COVID-19 phobia level in healthcare workers. The socio-demographic characteristics form and the Coronavirus 19 Phobia (CP19-S) Scale were used as data collection tools. The surveys were shared online on social media. 467 healthcare workers who agreed to participate in the study were reached. Employees who got 55.30 +/- 14.64 points from the scale total scores and university graduates were found to have an average of 55.51 +/- 14.11, and their families averaged 57.84 +/- 15.05. As a result, it was determined that the COVID-19 phobia levels of healthcare workers were affected by situations such as gender, education level and elderly family members. In this case, the importance of determining the working areas of healthcare professionals according to their phobia levels is emphasized, as it will affect the quality of care given to patients during the pandemic process.Öğe Determination of rational drug use knowledge levels of adult Syrians under temporary protection applying to immigrant health centers in Malatya province and related factors(2022) Baskiran, Deniz Yavuz; Pehlivan, Erkan; Çiçek, İpek Balıkçı; Bayır, BernaIn this study, it was aimed to determine the rational drug use knowledge level of Syrians under temporary protection who applied to migrant health centers in Malatya province and related factors. A total of 983 Syrian patients under temporary protection in four Migrant Health Centers in Malatya were included in the study. Socio-demo- graphic characteristics form and Rational Drug Use Scale were used as data collection tools. The mean duration of stay of the population included in the study in Turkey was 5.8±2 (1-12, median 6) years, and the mean duration of stay in Malatya was 5.2±2.1(1-10, median 6) years. According to the questionnaire on the Rational Drug Use Scale, the average score of the participants was approximately 6 points behind the cut-off value of 34 points. Only 23.1% of them were able to score 35 and above. While the scores of the patients did not differ according to gender, a weak correlation was found with age. In addition, it was determined that education level, year lived in Turkey, marital status and regular working life in Syria and living in a village or town were effective factors on rational drug use scores. According to the findings of this study, it was determined that the rational drug use knowledge level of the participants was low.Öğe A Recipient and Donor Both Have COVID-19 Disease. Should We Perform a Liver Transplant?(Springer, 2021) Tuncer, Adem; Akbulut, Sami; Baskiran, Adil; Karakas, Ezgi Erdal; Baskiran, Deniz Yavuz; Carr, Brian; Yilmaz, SezaiCoronavirus 2019 (COVID-19) is a new infectious disease that continues to spread globally. There is growing concern about donor-induced transmission of Coronavirus 2 (SARS -CoV-2). For liver transplantation, the COVID-19 PCR test is routine, in addition to epidemiological history and clinical and radiological examination 24-48 h before surgery. One of the liver transplant candidates was found to be infected with COVID-19, as well as the planned donor candidate. Since COVID-19 will be a high-risk operation for both the recipient and the donor, the operation was postponed by giving medical treatment. After the treatment and quarantine process was over, the patient and the donor then had a negative COVID-19 PCR test and the patient received a living donor liver transplant. We present a case of donor and recipient who initially both tested positive for COVID-19. This liver transplantation scenario has not previously been reported in the literature.Öğe The Significance of Serum Tumor Markers CEA, Ca 19-9, Ca 125, Ca 15-3, and AFP in Patients Scheduled for Orthotopic Liver Transplantation: Do Elevated Levels Really Mean Malignancy?(Springer, 2023) Baskiran, Deniz Yavuz; Sarigoz, Talha; Baskiran, Adil; Yilmaz, SezaiAim and Background Preparation of the patients for liver transplantation is a meticulous process and includes evaluation of tumor markers to rule out occult malignancy. The present study evaluated the significance of serum tumor markers in patients bound for liver transplantation due to viral and other etiologies of liver failure. Patients and Methods Three hundred eighty-one patients who underwent liver transplantation were included in the study. Demographic data, model for end stage liver disease (MELD) scores, and serum tumor marker levels were prospectively collected. Results AFP levels were significantly higher in viral etiologies when compared to other etiologies (p < 0.05). Ca 19-9 was significantly higher in viral etiologies (p < 0.05). Among the viral etiologies, HCV-related liver failure had higher carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (Ca 19-9) levels (p < 0.05). A correlation was found between increasing MELD scores and serum levels of tumor markers (p < 0.05). Conclusions Tumor markers such as AFP, CEA, Ca 125, and Ca 19-9 can be elevated in end stage liver disease. Their levels vary according to etiology and severity of disease. The diagnostic capabilities of these markers are reduced in end stage liver disease setting but they contribute to the evaluation of the pathophysiology of chronic liver disease. Transplantation can be performed safely in cases with high tumor marker levels provided that any occult malignancy is ruled out by means of imaging and endoscopic techniques. Tumor markers can guide the physician in determining the severity of liver cirrhosis, and further studies are needed to validate such a relationship.
