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Öğe Elde subkutan yerleşimli primer kist hidatik: Olgu sunumu(İzmir Atatürk Eğitim Hastanesi Tıp Dergisi, 2008) Dirican, Abuzer; Ünal, Bülent; Pişkin, Turgut; Aydın, Cemalettin; Bassullu, NurayÖZET maç: Kist hidatik hastalığı; Türkiye’nin de aralarında bulunduğu pek çok ülke için önemli bir sağlık sorunudur. Kist hidatik sıklıkla karaciğer ve akciğerde yerleşim göstermekle beraber tüm vucut dokularında yerleşim gösterebilir. Subkutan yerleşimli kist hidatik nadirdir. Bu yazıda subkutan kist hidatik olgusu eşliğinde hastalığın tanı ve tedavi yöntemleri değerlendirilmiştir. Olgu sunumu: 67 yaşında erkek hasta son bir yılda sol el avuç içinde büyüyen şişlik şikayeti ile başvurdu. Hastaya öntanı olarak lipom düşünüldü. Eksizyon sırasında germinatif memebranla karşılaşıldı. Patolojik inceleme sonucunda kist hidatik tanısı kondu. Hastanın geçirilmiş kist hidatik hastalığı öyküsü yoktu ve başka organda kist hidatiğe rastlanmadı. Hastanın 3 yıllık izleminde hidatik kist nüksüne rastlanmadı. Sonuç: Kist hidatiğin endemik olduğu bölgelerde subkutan kistik kitlelerin ayırıcı tanısında kist hidatik de hatırlanmalıdır ve nüks ihtimaline karşılık kist total eksize edilmelidir.Öğe The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: Role of matrix metalloproteinases in tumor progression and prognosis(Aves, 2009) Kirimlioglu, Hale; Turkmen, Ilknur; Bassullu, Nuray; Dirican, Abuzer; Karadag, Nese; Kirimlioglu, VedatBackground/aims: Carcinomas of the biliary tree are rare tumors of the gastrointestinal tract, with an increasing incidence in recent years. Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma. We aimed to determine the expression profile of matrix metalloproteinase (MMP)-2, MMP-9 and MMP-14 in the biliary neoplasms classified according to their localization and the relation with the prognosis. Methods: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study. The immunohistochemical expression of MMP-2, MMP-9 and MMP-14 was detected in the nontumoral, metaplastic, dysplastic and tumoral epithelia. The tumor differentiation, angiolymphatic and perineural invasion of the tumor, and presence of lymph node and distant metastasis were determined. Survey of the patients was noted from the patient follow-up data. Results: The nontumoral epithelia of the gallbladder, intrahepatic ducts, and Klatskin tumor did not express MMP-2. MMP-2 expression was detected in the distal part of the biliary ducts, in 7.5% (6118) of cases and in. the nontumoral epithelia of the ampullary region in 50% (5110) of cases. The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors. In the intrahepatic cholangiocarcinoma, the hepatocytes were positively stained but the infiltrative tumors were spared. Klatskin tumors were also not stained with MMP-2. The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively. MMP-9 and MMP-14 were expressed in normal, inetaplastic, and dysplastic epithelium and tumoral cells in all of the cases of the groups. Expressions of MMAs were higher in subjects with neural invasion, but there was no correlation between MMP expression and tumor differentiation or angiolymphatic invasion. Conclusions: When tumors of the biliary system are divided as intrahepatic and extrahepatic cholongiocarcinomas, MMP-2 expression was present in the extrahepatic cholangiocarcinomas including gallbladder carcinomas. Like the intrahepatic cholangiocarcinoma, Klatskin. tumors also did not express MMP-2. This can be related with its characteristic growth pattern. MMP-9 and MMP-4 were present in metaplasia, dysplasia carcinoma sequence in all of the bile tract tumors, suggesting that MMPs play art important role in carcinogenesis. The higher expression of the MMPs with neural invasion suggests the significant role of those tumors in the invasion activity.Öğe Intraductal Papillary Mucinous Neoplasia in Ectopic Pancreas Located in the Jejunum: Case Report(Ortadogu Ad Pres & Publ Co, 2011) Bassullu, Nuray; Turkmen, Ilknur; Yilmaz, Mehmet; Comunoglu, Cem; Aydin, N. EnginEctopic pancreas is a commonly seen congenital anomaly in gastrointestinal system, but jejunal pancreatic heterotopia is seen rarely. Although every pathological change that occurs in the pancreas can be seen in its heterotopic counterpart, neoplasia is an unusual complication. Intraductal papillary mucinous neoplasms (IPMNs) are tumors originate from ductal epithelial cells of the pancreas that constitute the main pancreatic duct or its major side branches and have a low incidence. Only two cases regarding the IPMN in heterotopic pancreas have been reported previously, but none of them were located in the jejunum. An IPMN in an ectopic pancreas tissue located in the jejunum in a 62-year-old male patient who presented with ileus is presented. It is important to recognize a tumor arising in heterotopic pancreas in order to prevent its misinterpretation as metastatic tumor or direct invasion of another tumor. To the best of our knowledge, this is the first reported IPMN case occurring in ectopic pancreas tissue located in the jejunum.Öğe Subcutaneous Fat Necrosis Mimicking a Malignant Mass Associated with the Left Internal Oblique and the Sartorius Muscles in a 3 Months Old Boy: Differential Diagnosis(Ortadogu Ad Pres & Publ Co, 2009) Sigirci, Ahmet; Karaman, Abdurrahman; Bassullu, Nuray; Celik, TayfunSubcutaneous fat necrosis (SCFN) is a rare, self-limited and benign disorder that develops after birth. A 3-month-old-boy presented with a semi-mobile mass under the skin without erythema on the left inguinal area. Ultrasound (US) revealed a mass within the subcutaneous fat layer over the left internal oblique and the sartorius muscles with heterogenous echogenicity. Computed tomograpy (CT) showed that the mass had a smooth border with partially spicular extensions to the subcutaneous fat. The presumptive diagnosis was rhabdomyosarcoma. Surgical exploration and excision biopsy were performed. The pathological examination revealed SCFN.
