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    Is lesser curvature resection for GIST can be associated with delayed gastric emptying?
    (2020) Donder, Yunus; Baykan, Mehmet; Sevim, Yusuf; Ertan, Tamer; Karagoz Eren, Saliha
    Aim: Patients who performed wedge resection of the lesser curvature of the stomach due to GIST were evaluated for delayed gastric emptying. Material and Methods: Thirty patients who underwent wedge gastric resection for GIST in stomach between 2009-2019 were evaluated retrospectively. In Seven patients it is located in lesser curvature. Results: Fifty-five patients were operated between 2009 and 2019 for GIST.In 7 patients, GIST was found to be located in the lesser curvature of the stomach. Of the 7 patients, 2 (%28) were male and 5 (%72) were female. Laparoscopy was performed in 4 patients and conventional procedure was performed in 3 patients. The average age was 56±10.5 (46-67) years in the conventional procedure group, and 61.5±10.4 (50-73) in the laparoscopic group. Average hospital stay was 4.67±1.5 (3-6) days for conventional procedure and, 2.75±0.9 (2-4) days for the laparoscopic group. Age and length of hospital stay were not different between the two groups (p=0.522 and p=0.094, respectively).All patients had normal radiological findings. Stool discharge was observed on postoperative day 3 at the latest. Conclusion: In conclusion, resection of lesser curvature (with laparoscopic or conventional procedure) GISTs with a tumor free surgical margin staying near to the gastric wall to prevent vagal nerve injury is feasible without gastric emptying problems.
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    The preventive effect of sulforaphane on liver injury in a non-heart-beating donor model
    (2021) Baykan, Mehmet; Yilmaz, Zeki
    Aim: In this preliminary study, we aimed to investigate the effect of sulforaphane (SFN) warm ischemia in a non-heart beat rat liver model (NHBD). Materials and Methods: Livers taken from NHBD 15,30,60 min after warm ischemia were stored up at University of Wisconsin solution for 5 h at 40C [cold storage (CS)] and were, then, exposed to 2 h of machine reperfusion (MRP) at 370C. In the study group, SFN 5 mg/kg was intraperitoneal given 30 min before the introduction of NHB. Firstly, we divided the rats into the control and SFN groups. Then, each group was divided into three groups (n=10 in each) including control I, II, III and SFN I, II, III groups (15-, 30-, and 60-min warm ischemia period, respectively).Control and study groups at the same time of ischemia were compared with each other in terms of lactate, AST, ALT, IL-6, TNF-α and morphologically.Results: In the group treated with SFN, AST, ALT, TNF-α, IL-6, and lactate levels were lower, compared to the control group. Histopathologically, Bcl-2 staining intensity and percentages of staining were statistically significant, compared to the control and study groups during 15-min warm ischemia. Although not statistically significant, the intensity and percentage of staining were higher at 30 min and identical at 60 min. Conclusion: Our study results suggest that, despite prolonged warm ischemia time, SFN can biochemically and morphologically protect the liver from the hazardous effects of ischemia reperfusion in an experimentally-controlled NHB in rats, indicating an increased utilization rate of NHBDs.