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    The level of endothelin-1 and nitric oxide in patients with chronic viral hepatitis B and C and correlation with histopathological grading and staging
    (Wiley, 2006) Ersoy, Y; Bayraktar, NM; Mizrak, B; Ozerol, IH; Gunal, S; Aladag, M; Bayindir, Y
    Background and aim: The aim of this study was to estimate the serum levels of endothelin-1 (ET-1) and nitric oxide (NO) and to analyze the correlation of their levels with histopathological grading and staging of the liver in patients with chronic hepatitis B (CHB) and C (CHC). Methods: Eighty-nine patients who were either HBsAg positive (45 CHB patients, 34 inactive carriers (IQ) or had CHC (10 patients) and 36 healthy volunteers as a control group were included in this study. Fifty patients from the CHB (n = 43) or CHC (n = 7) groups with elevated serum alanine transaminase (ALT) levels underwent a liver biopsy. Histological activity was scored according to Ishak's activity and the fibrotic index. The ET-1 serum concentration was determined with a commercially available ELISA assay kit. Total nitrite was measured by the Griess reaction as an index for NO production. Results: Serum levels of ET-1 and NO were significantly increased in CHB patients (7.67 +/- 4.00 pg/ml and 172.44 +/- 50.30 mu mol/l, respectively) compared with the IC group (3.99 +/- 5.42 pg/ml and 114.68 +/- 32.22 mu mol/l, respectively) and the control group (3.05 +/- 0.65 pg/ml and 58.61 +/- 24.18 mu mol/l, respectively) (p < 0,000 1). The CHC patients also had significantly higher serum levels of ET- 1 (5.92 +/- 4.24 pg/ml) and NO (147.50 +/- 55.84 mu mol/l) compared to the control group (p < 0.0001 and < 0.001, respectively). Linear regression analysis identified that the level of ET- I was an independent variable that correlated significantly with the stage score (r(2) = 0.348, p < 0.0001) in CHB patients but there was no correlation in the CHC group. Conclusion: ET-1 and NO levels were increased in chronic hepatitis and there was a significant correlation between the ET-I level and the stage in CHB patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.