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    Definition and prevalence over the years of polypharmacy in Turkey: A systematic review
    (Marmara Univ, 2023) Goncuoglu, Cansu; Ozdemir, Nesligul; Kara, Emre; Bayraktar-Ekincioglu, Aygin
    Identification of the trend of polypharmacy over the years is as valuable as determining the common definitions for taking precautions. The aim of this systematic review is to reveal the frequency, commonly used definitions and its change over the years of polypharmacy in Turkey. The reporting of this systematic review follows to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA 2020) checklist. The MEDLINE and ULAKBIM TR Dizin databases were searched for relevant studies published until April, 2021. The studies conducted with patients >18 years in Turkey were included. A total of 361 articles were identified and 52 articles met the inclusion criteria. The most common definition of polypharmacy was 'combination of 5 or more drugs', followed by the definitions of 'two or more drugs' to '10 or more drugs; and its prevalence ranged between 9% and 95% in the studies. It was determined that the most commonly used definition of polypharmacy was 'the use of 5 or more drugs'. The prevalence of polypharmacy in Turkey was appeared in a wide range and found higher than the studies in the literature. The prevalence and trends of polypharmacy over the years should be carefully observed, inappropriate use of medicines should be examined and necessary precautions should be taken accordingly.
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    Impact of pharmacist-led educational intervention on pneumococcal vaccination rates in cancer patients: a randomized controlled study
    (Springer, 2023) Ozdemir, Nesligul; Aktas, Burak Y. Y.; Gulmez, Ahmet; Inkaya, Ahmet C. C.; Bayraktar-Ekincioglu, Aygin; Kilickap, Saadettin; Unal, Serhat
    Purpose This study aimed to evaluate clinical pharmacist's contribution to the pneumococcal vaccination rate by providing education to cancer patients in hospital settings. Methods This study was conducted in 2 tertiary-care hospitals' medical oncology outpatient clinics. Patients over 18 years of age and diagnosed with cancer for less than 2 years, in remission stage, and have not previously received the pneumococcal vaccine were included. Patients were randomized to intervention and control groups. The intervention group was provided vaccination education and recommended to receive the PCV13 vaccine. The control group received routine care. Patients' knowledge about pneumonia/pneumococcal vaccine, Vaccine Attitude Examination Scale (VAX) score, and vaccination rates were evaluated at baseline and 3 months after the education. Results A total of 235 patients (intervention: 117, control: 118) were included. The mean age +/- SD was 57.86 +/- 11.88 years in the control and 60.68 +/- 11.18 years in the intervention groups. The numbers of correct answers about pneumonia/pneumococcal vaccine (p = 0.482) and VAX scores (p = 0.244) of the groups were similar at baseline. After the intervention, the median (IQR) number of correct answers in intervention group [10(3)] was higher than control group [8(4)] (p < 0.001). After the education, the total VAX score (mean +/- SD) was less in intervention group (33.09 +/- 7.018) than the control group (36.07 +/- 6.548) (p = 0.007). Three months after the education, 20.2% of the patients in the intervention and 6.1% in the control groups were vaccinated with pneumococcal vaccine (p = 0.003). Conclusions The pneumococcal vaccination rate in cancer patients has increased significantly by the education provided by a clinical pharmacist in hospital settings.
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    Vaccination attitudes and practices of physicians and nurses in adult oncology settings
    (Marmara Univ, 2024) Ozdemir-Ayduran, Nesligul; Aktas, Burak Y.; Kilickap, Saadettin; Bayraktar-Ekincioglu, Aygin
    This study aimed to assess the opinions and clinical practices of oncologists and nurses about vaccination recommended for both healthcare workers and cancer patients. A cross-sectional survey study was conducted among physicians and nurses working in adult oncology settings between September 2019 and February 2022. An online survey was sent to the participants via e-mails, with two reminders at 4-week intervals for non-respondents. A total of 80 physicians and 84 nurses completed the survey. The highest vaccination rates for physicians and nurses were reported for hepatitis B, diphtheria-tetanus, and influenza vaccines. Considering the previous influenza season, only 31.25% of the physicians and 22.62% of the nurses had the influenza vaccine. Eighty-seven percent (n=70) of physicians and 57.14% (n=48) of nurses recommended adult vaccines to cancer patients. Influenza, pneumococcal, and hepatitis B vaccines were the most recommended vaccines. Thirty-seven percent of physicians and 44.05% of nurses encountered anti-vaccine attitudes among the patients. Seventeen percent of the physicians had no opinion on the timing of vaccination during conventional cytotoxic chemotherapy. Forty percent, 28.17%, and 18.31% of physicians recommended vaccination 'just before treatment', 'between treatment cycles', and 'immediately after the end of treatment', respectively. Vaccination rates of physicians and nurses working in oncology practice and the recommendation of vaccination to cancer patients are still lower than desired levels. It appears that HCPs have limited knowledge regarding vaccination time schedules in cancer patients.