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Öğe Comparison of Propofol and Ketamine-Propofol Mixture (Ketofol) on Laryngeal Tube-Suction II Conditions and Hemodynamics: A Randomized, Prospective, Double-Blind Trial(2013) Ozgul U.; Begec Z.; Karahan K.; Ali Erdogan M.; Said Aydogan M.; Colak C.; Durmus M.Objective: The aim of our study is to compare the effect of ketamine-propofol mixture (ketofol) and propofol on the laryngeal tube-Suction II (LTS II) insertion conditions and hemodynamics. Methods: Eighty American Society of Anesthesiologists class 1 and 2 patients were divided into 2 random groups to receive either 1 ?g/kg remifentanil and propofol 2 mg/kg in Group P (n = 40), or 1 ?g/kg remifentanil and ketofol (using a 1:1 single syringe mixture of 5 mg/mL ketamine and 5 mg/mL propofol) in Group K (n = 40) before induction of anesthesia. After induction, LTS II was inserted. Heart rate and noninvasive blood pressure were recorded before induction of anesthesia (t0); immediately following induction (t1); immediately after LTS II insertion (t2); and 3 minutes (t3), 5 minutes (t4), and 10 (t5) minutes after LTS II insertion. Conditions of insertion of LTS II were assessed and scored 1 to 3 using 6 variables as follows: mouth opening, swallowing, coughing, head and body movements, laryngospasm, and ease of LTS II insertion by the same experienced anesthesiologist who did not know the agents. LTS II insertion summed score was prepared depending upon these variables. Results: In regard to LTS II insertion summed score, Group K was more favorable than Group P (P < 0.05). Apnea duration was longer in Group P (385.0 seconds [range = 195.0-840.0 seconds]) compared with Group K (325.50 seconds [range = 60.0-840.0 seconds]) but this was not statically significant. The heart rate values were significantly lower at all measurement intervals in both groups compared with the baseline values (P < 0.05). There was no difference in heart rate between Group P and Group K. The mean arterial pressure values were significantly lower at all measurement intervals in Group P compared with baseline values (P < 0.05). In Group K, the mean arterial pressure values were significantly lower at all measurement intervals compared with the baseline values, except t2 (P < 0.05). There was a significant difference between Group P and Group K in terms of mean arterial pressure at t3 (P < 0.05). Conclusions: We found that ketofol provided better insertion summed score for LTS II than propofol, with minimal hemodynamic changes. © 2013 The Authors.Öğe Does single dose premedication of dexmedetomidine reduce pain during injection of propofol?(2007) Erdil F.A.; Gulhas N.; But A.K.; Begec Z.; Ersoy M.O.Background and objective: Pain on injection is still a major problem with propofol. In this study, we compared the efficacy of single-dose premedication of dexmedetomidine for pain on injection of propofol and its effect on the incidence and the severity of the pain after propofol injection. Methods: We conducted a prospective, randomized and double-blind study of 100 patients scheduled to undergo surgery. Patients were randomly assigned to one of two groups, either receiving dexmedetomidine (Group D) or saline (Group C) before the injection of propofol. Patients in Group D (n = 50) were given dexmedetomidine infusion 0.6 ?g/kg for 10 min. Patients in Group C (n = 50) were given saline infusion in an identical manner. Pain perception was assessed during injection of propofol in all patients. Results: The median pain score on injection of propofol was significantly lower in Group D than in Group C (median pain score 2 [1-3] vs 1 [0-2]; P < 0.006). The number of patients with pain in Group D decreased (48/50 [96%] in Group C vs 42/50 [84%] in Group D; P = 0.046). Conclusions: Intravenous administration of a single dose of dexmedetomidine as a premedication reduced the incidence and severity of pain on propofol injection without significant adverse haemodynamic effects. © 2007 W.S. Maney & Son Ltd.Öğe Efeitos antimicrobianos de cetamina em combinação com propofol: Um estudo in vitro(Elsevier Editora Ltda, 2013) Begec Z.; Yucel A.; Yakupogullari Y.; Erdogan M.A.; Duman Y.; Durmus M.; Ersoy M.O.[No abstract available]Öğe Performance of size 1 I-gel compared with size 1 ProSeal laryngeal mask in anesthetized infants and neonates(Hindawi Publishing Corporation, 2015) Kayhan G.E.; Begec Z.; Sanli M.; Gedik E.; Durmus M.Purpose. The size 1 I-gel, recommended for small infants and neonates weighing 2-5 kg, has recently been released. There are no prospective studies available that assess the insertion conditions, sealing pressures, or ventilation quality of it. This study was designed to compare the performance of recently released size 1 I-gel with size 1 ProSeal LMA. Methods. Fifty infants and neonates, ASA I-II were included in this prospective, randomized, and controlled study. Patients were divided into two groups for placing I-gel or ProSeal LMA. The primary outcome was airway leak pressure, and secondary outcomes included insertion time, insertion success and conditions, initial airway quality, fiberoptic view of the larynx, and complications. Results. There were no significant differences in terms of airway leak pressure between the I-gel (27.44 ± 5.67) and ProSeal LMA (23.52 ± 8.15) (P = 0.054). The insertion time for the I-gel was shorter (12.6 ± 2.19 s) than for the ProSeal LMA (24.2 ± 6.059 s) (P = 0.0001). Insertion success and conditions were similar in groups. We encountered few complications. Conclusion. Our study demonstrates that the size 1 I-gel provided an effective and satisfactory airway as the size 1 ProSeal LMA. It may be a good alternative supraglottic airway device for use in small infants and neonates. This trial is registered with: ClinicalTrials.gov NCT01704118. © 2015 Gulay Erdogan Kayhan et al.Öğe Serum electrolytes and nitric oxide levels in acute hypotension following intravenous heparin(2006) Toprak H.I.; Begec Z.; But A.; Sizanli E.; Bayraktar N.; Ersoy M.O.Heparin is frequently used as an anticoagulant agent for patients undergoing surgery with cardiopulmonary bypass. In literature, severe hypotension as a side effect of high dose bolus heparin has been already reported. However, the exact mechanism of hypotension has not yet fully been understood. The aim of the study was to investigate the relationship between hemodynamic instability induced by heparin and levels of serum electrolytes and nitric oxide. Forty patients undergoing elective coronary artery bypass grafting were included into the study. Patients with sudden decrease in mean arterial pressure (MAP) higher than 25 % of the baseline after heparin administration were included into group H (n=20). Besides, consecutive twenty hemodinamically stabile patients (with none or a MAP decrease lower than 25 % of baseline) constituted group N (n=20). Anesthetic techniques were standardized. Arterial blood gases were analyzed for pH, PaO2, PaCO2, potassium, sodium, calcium, magnesium, hematocrit before and 5 minutes after heparin administration. Synchronous serum nitric oxide levels analysis were also performed. The nitric oxide levels were measured as reflected by the formation of its stable end-metabolites, nitrite and nitrate. Serum electrolyte and nitric oxide levels were not statistically different neither between before and after heparin administration nor between hypotension group and normotension group. Hypotension observed after heparin administration was not related with the concentration of serum electrolytes and nitric oxide.
