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    Association between fragmented QRS complexes and left ventricular dysfunction in healthy smokers
    (Wiley, 2019) Bayramoglu, Adil; Tasolar, Hakan; Bektas, Osman; Kaya, Ahmet; Gunaydin, Zeki Yuksel
    Objective: Smoking is a known risk factor for cardiovascular diseases and may cause myocardial damage independently of coronary artery disease. Fragmented ORS (f(lRS) is an important marker of myocardial fibrosis, while speckle-tracking echocardiography is a method used to show subclinical left ventricle dysfunction. Methods: Our study included 230 healthy individuals aged 18-40 years. The patients included were separated into two groups: those smokers (n = 130) and nonsmokers (n = 100). After that healthy smokers group were divided into two groups: those with fQRS (n = 24) and those without (n = 106). In both groups, the arithmetic mean of three images was used to obtain the left ventricle global longitudinal strain (LV-GLS). The E/SRe ratio was also calculated and analyzed. Results: There were significant differences between the smokers and non-smokers in terms of, E/SRe (55.7 +/- 17.9 vs 50.3 +/- 14.8; = 0.015), LV-GLS (23.1 +/- 1.9 vs 24.0 +/- 1.7; P = 0.001), and fQRS (18.5% vs 6%; P = 0.005). As a result of subgroup analysis, pack-year history was higher in the fQRS positive group (16.7 +/- 3.7 vs 11.2 +/- 3.7, P < 0.001). While a negative correlation was observed between pack-year history and LV-GLS (r =-0.678, P < 0.001), there was a positive correlation between pack-year history and E/SRe (r = 0.730, P < 0.001). Conclusion: In conclusion, our study demonstrated that fQRS is a parameter that can be used to determine left ventricle subclinical systolic and diastolic dysfunction in smokers, and that left ventricle dysfunction is related to the duration and intensity of smoking.
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    The factors affecting the duration of hospitalization in pulmonary embolism
    (2020) Dereli, Seckin; Bektas, Osman; Cebeci, Zubeyir
    Aim: The factors affecting the duration of hospitalization in PTE were evaluated In this multicenter , retrospective study.Materials and Methods: A total of 161 patients who were diagnosed as PTE were enrolled in the study. The diagnoses of all patients were confirmed via computed tomographic pulmonary angiography (CTPA). The median duration of hospitalization was calculated as 9 days. Patients were divided into two groups. Short-stay group was consisted of patients who were hospitalized for less than 9 days while the patients who were hospitalized for more than 9 days composed the long-stay group. Result: The mean hospital stay was 7.84 days (interquartile range, 5-17 days). Concerning CTPA findings; Pulmonary thromboembolism index (%) was significantly higher in long-stay patients (52.61 ± 24 versus 38.59 ± 23, p = 0.001). In addition, right and left pulmonary artery diameter, right ventricle (RV) diameter and RV/LV ratio significantly affected the length of hospital stay. Elevated levels of BNP (516 mg/dL, 10-4694 versus 269 mg/dL, 10-1400 p = 0.014) and troponin (0.7 mg/dL, 0.1-3.7 versus 0.1 mg/dL, 0.1-3 p = 0.024) were also associated with prolonged hospital stay. Conclusions: Increased right and left pulmonary artery diameters, pulmonary artery pressure, RV diameter/LV diameter ratio and pulmonary artery diameter/aortic conus diameter ratio were found to be associated with prolonged hospital stay. The higher levels of CRP and d-dimer did not have any effect on the duration of hospitalization.The rates of bleeding did not affect the length of hospitalization, regardless of the type of treatment.