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    The effect of chronic carbon monoxide exposure on brain in Barbecue workers
    (Parlar Scientific Publications, 2014) Turtay M.G.; Yumrutepe S.; Kahraman A.S.; Bentli R.; Oguzturk H.; Firat C.; CoIak C.
    The aim of our study is to investigate whether chronic carbon monoxide (CO) exposure has effects on the brains of the people who work as barbecue workers (BWs) for a long time. Twenty males who had been working in the indoor environments of various restaurants (Group 1) and 20 healthy males who were matched by age with the other group (Group 2) were included in the study. Laboratory tests were performed in both groups of people. Magnetic Resonance Spectroscopy (MRS) was applied to the people whose blood samples were taken. In Group 1, significant correlations were not detected between carboxyhemoglobin (COHb) values and the variables of age, working hours, hemoglobin (Hb), white blood cell (WBC), hematocrit (HCT), platelet (PLT), mean platelet volume (MPV), pH, oxygen saturation (Sat 02) (p> 0.05). In terms of Hb, WBC, HCT, PLT, MPV, pH, Sat 02, COHb, N-acetylaspartate/creatine in basal ganglion, choline/creatine in basal ganglion, N-acetylaspartate/creatine in frontal lobe periventricular white matter, choline/creatine in frontal lobe periventricular white matter variables, significant differences between Group 1 and Group 2 were not determined. (p>0.05). As a result of this study; it is detected that chronic exposure to CO in BWs does not have any effects on brain with respect to MRS imaging method.
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    Effects of sleep quality, income level and comorbid conditions on quality of life in a Turkish elderly population: A multicentre study
    (Geriatrics Society, 2015) Gündüz E.; Eskin F.; Gündüz M.; Bentli R.; Selçuk E.B.; Zengin Y.; İcer M.
    Introduction: Our aim is to investigate the effects of sleep quality, income level and comorbid conditions on Quality of Life in a Turkish elderly population. Materials and Method: This multicentric study was performed in seven districts. A total of 1030 patients older than 65 years of age who applied to the internal medicine and geriatrics outpatient clinics of study centres between January and December 2014 were included. All patients underwent the Pittsburgh Sleep Quality Index and Quality of Life Assessment (Short Form 36) tests viaface to face interview method. The demographic properties of patients were also recorded during this interview. Results: The mean Quality of Life subscale scores, except for vitality, were significantly lower (p<0.001) in patients with poor sleep quality. When analysing the relationship between Quality of Life and multiple chronic diseases, it was observed that patients having multiple chronic diseases had significantly lowered scores in three subscales (physical functioning, mental health and bodily pain; p=0.04, p=0.04, p=0.01, respectively). There were significant differences between patients with high versus low income level with respect to the mean physical functioning, mental health and bodily pain subscales (p=0.01). Conclusion: Our study demonstrated an adverse effect of low sleep quality, multiple chronic disorders and low income level on Quality of Life. © 2015, Geriatrics Society. All rights reserved.
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    Serum ghrelin levels during fracture healing and immunohistochemical investigation of ghrelin in bone tissue
    (Acta Medica Mediterranea, 2014) Emeli A.; Inanmaz M.E.; Isik C.; Bentli R.; Karakurt L.; Belhan O.
    Background: Ghrelin is a hormone with efficacy on increasing osteoblastic cell proliferation, differentiation, growth hormone release, and preventing apoptosis. The present study aimed to investigate whether ghrelin has a role in bone fracture healing process and presence in the bone tissue. Patients and methods: Blood samples of 10 patients, who underwent surgery for fracture repair, were obtained for 4 times in the manner that; before fracture stabilization (preoperative) and on the postoperative 1st, 10th, and 60th days. Additionally, blood samples were obtained from 10 healthy subjects (control group). Ghrelin levels in serum samples were measured by enzyme-linked immunosorbent assay method and presence of ghrelin was immunohistochemically investigated in bone tissue samples . Results: Although no difference was found between the groups in terms of blood levels of ghrelin, it was observed that acylated ghrelin level was increased beginning from the postoperative 1st day as compared to the control group. Des-acylated ghrelin levels were also increased as compared to the controls, except for the postoperative 10th day. Ghrelin was not detected in bone tissues. Osseous union was observed in all patients of the fracture group. Conclusions: we thought that increased acylated and des-acylated ghrelin levels were contributed to fracture healing process by means of enhancing cell proliferation, preventing apoptosis, presenting anti-inflammatory and antimicrobial effect and increasing growth hormone release.