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    Association of laryngopharyngeal reflux with nasal obstruction
    (2019) Cakar, Hasan; Bercin, Sami; Sevil, Ergun; Kiris, Muzaffer
    Aim: To evaluate the effect of nasal obstruction on the laryngopharyngeal reflux (LPR). Material and Methods: Between April 2013 and October 2014, 40 patients with a diagnosis of nasal septum deviation and 40 controls with no signs and symptoms of reflux were prospectively included in this study. Results of pH monitoring of two groups of patients were analyzed for LPR. In the evaluation, two different criteria, based on reflux number and time spent in reflux were used. Results: The proximal canal reflux episode ratios were found 3.0±4.18, 2.05±3.81 and 5.05±7.35 for upright, supine and totally in the study group respectively. These ratios were found 0.94±0.29, 0.0±0.0 and 0.94±0.29 for upright, supine and totally in the control group respectively. Upright, supine and total reflux episodes of patients in the study group were found higher than the control group and these differences reached statistically significant in two groups (p<0.05). The distal canal upright, supine and total reflux episodes of patients in the study group were found higher than the control group. This difference was found to be statistically significant in the total reflux episode patients (p<0.05). Conclusion: Nasal obstruction had a negative effect on LPR and that may play a role in the formation of reflux.
  • Küçük Resim
    Öğe
    Dynamic thiol-disulfide balance in patients with chronic sinusitis with and without nasal polyposis
    (2020) Sevil, Ergun; Gul, Fatih; Oguzhan, Tolga; Bercin, Sami; Neselioglu, Salim; Bicer, Cemile
    Aim: Reactive oxygen species (ROS) have a crucial role in the pathogenesis of chronic rhinosinusitis (CRS). The current study investigates a novel oxidative stress marker (thiol (SH)/disulfide (SS) homeostasis) in patients with CRS with and without nasal polyposis (NPs).Materials and Methods: A total of 167 subjects, including 94 patients with CRS and 73 healthy controls, were included in the study. The patients were subdivided into two groups those with CRS with NP and those with CRS without NP. Comparisons were made between the groups in respect of serum native SH, total thiol (TT), and SS levels and the SS/SH and SS/TT ratios. Results: There was no significant difference in TT between the CRS with the NP group and the CRS without the NP group (p> 0.05). There was a significant difference (p 0.05) between the CRS without the NP group and the control group in %SH/TT, %SS/TT, %SS/SH, SS, and SH. A significant difference (p 0.05) was found between the CRS with the NP group and the control group in %SH/TT, %SS/TT, %SS/SH, SS and SH values. Conclusion: Dynamic SH/SS homeostasis shifts towards SS formation as a result of SH oxidation in patients with CRS.