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    Can Blood Biomarkers Be Used to Assess Oxidative Stress in COPD Patients After Pulmonary Rehabilitation
    (Dove Medical Press Ltd, 2023) Beykumul, Aysegul; Ersoy, Yuksel; Gulbas, Gazi; Neselioglu, Salim
    Purpose: To determine the level of oxidative stress in the body due to pulmonary rehabilitation (PR) with thiols and disulfide and to investigate their relationship with indirect markers such as creatine kinase (CK), creatine kinase - MB (CK-MB), and lactate dehydrogenase (LDH), which show cell destruction.Patients and Methods: Patients with chronic obstructive pulmonary disease (COPD) are included in inpatient and outpatient care. They were evaluated before and after for PR, and an exercise program was prescribed. In addition, native thiol (NT), total thiol (TT), disulfide (DS), LDH, CK, and CK-MB values were tested.Results: The mean age of 21 patients was 63 +/- 7.31 years. Eleven of them were outpatients and 10 of them were inpatients. Most of the patients were male (M/F=20/1, 95.2/4.8%). There was a significant difference in pulmonary function tests (PFT), St. George Respiratory Questionnaire (SGRQ), and 1 repetition maximum (1RM) before and after the treatment (p<0.001). There was a correlation between PFT and 1RM upper extremity. While there was no significant difference between thiols and disulfide, according to GOLD scores, there was a significant difference in patients with level 3-MMRC. No correlation was found between LDH, CK, CKMB, and thiols, DS. Delta CK was found to be associated with Delta DS, and Delta CK-MB with Delta NT, and Delta TT.Conclusion: PR contributes to the antioxidant process by improving respiration and reducing oxidative stress. The decrease in LDH, CK with PR, increase in CK-MB, and correlation of CK with thiols and DS gave a different interpretation. In this case, it should be considered that oxidative stress may also be increased in people with high CK values.
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    DO disease stages affect oxidative stress in stable COPD?
    (Cell Press, 2024) Yalcinsoy, Murat; Beykumul, Aysegul; Gulbas, Gazi; Arslan, Ahmet Kadir; Neselioglu, Salim
    Background: Detection of oxidative stress level may lead us to understand the pathogenesis of COPD better and to search for new treatments. Oxidative stress levels have also been shown to be elevated in stable COPD patients. We aimed to investigate whether the stage of COPD affects the severity of inflammation-induced oxidative stress in patients with stable COPD. Methods: Between June 2019 and March 2020, all consecutive patients admitted to COPD-specific outpatient clinics were included. Patients were classified A, B, and E according to the GOLD guideline. Results: The median age of 98 patients (Male: 92 (93.9 %)) was 65 (min-max: 49-86). A statistically significant difference was found between the groups in FEV1, FVC, and FEV1/FVC (p < 0.001). age, and thiols (r = -0.168, p = 0.049; r = -0.184, p = 0.035) and DS (r = -0.209, p = 0.019) were found to be negatively correlated at a low level. When adjusted for age, oxidative stress parameters were similar between stages. Conclusion: No difference between stages and oxidative stress parameters according to GOLD classification in stable COPD patients. Our results may be a guide for not using anti-inflammatory therapy except for attacks.
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    The effect of 10 weeks of karate training on the development of motor skills in children who are new to karate
    (Frontiers Media Sa, 2024) Arslan, Yasin; Yavasoglu, Belma; Beykumul, Aysegul; Pekel, Aylin Ozge; Suveren, Ceren; Karabulut, Ebru Olcay; Ayyildiz Durhan, Tebessum
    This study investigated the effect of a 10-week karate training program on the motor skill development of 5-7-year-old children new to karate with two different test batteries. A total of 28 participants were included in the study: 18 in the Karate group and 10 in the control group. The karate group was subjected to a fundamental karate training (kihon) program consisting of 90-minute sessions four days a week for ten weeks in addition to physical education classes at their schools. In contrast, the control group did not participate in any sportive activities except physical education classes in their schools. Data were collected using the Eurofit test battery and the TGMD-2 test. In the pre-post test comparison of the anthropometric measurements of the karate group, no significant difference was found in the control group. In contrast, a significant difference was obtained in height, body mass index, and body fat percentage. In the post-test analysis of the two independent groups, there were statistically significant differences in favor of the karate group regarding height and body fat percentage (p < 0.005). In the pre-post analysis of the Eurofit test and the TGMD-2 for the karate group, all parameters showed statistically significant improvements (p < 0.001), while the control group showed no statistical difference. After comparing the karate and control groups, the Eurofit Test and TGMD-2 post-test results showed significantly higher scores (statistically significant differences) in all parameters for the karate group. In conclusion, the study shows that the 10-week karate training program positively affected the motor development of the participating children.
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    Effect of 6-week karate (kihon) and basic movement exercise on balance performance in visually impaired individuals
    (Frontiers Media Sa, 2023) Pekel, Aylin Ozge; Suveren, Ceren; Arslan, Yasin; Yavasoglu, Belma; Beykumul, Aysegul; Durhan, Tebessum Ayyildiz; Ceylan, Levent
    Today, the participation of visually impaired individuals in sports activities is essential. Because the ability to move independently starts to develop with a delay in visually impaired individuals, physical activity is necessary to compensate for developmental delay, eliminate the problem of independent movement in social life by reducing obstacle perception problems, develop self-confidence, and provide regular muscle activation and motivation to move. The study investigated the effect of 6 weeks of karate (kihon) and basic movement training on balance performance in individuals with congenital visual impairment. Fifteen visually impaired individuals aged between 10 and 14 participated in the study, and three groups were formed: experiment 1, experiment 2, and the control group. After the pre-tests were taken, the experimental groups received karate and basic movement training in addition to physical education classes for 6 weeks, while the control group received only physical education classes. When the study results were examined, there were highly significant differences between the pre- and post-test values of the groups receiving karate and basic movement training. At the same time, no progress was observed in the control group. In the post-test comparison of the karate and control groups, positive significance was found in the values of the karate group. In the same way, in the post-test comparison of the basic movement training group and the control group, positive progress was made in the basic movement training group. The post-test comparison of the basic movement training and karate groups was the same. As a result, it was concluded that basic movement training and karate exercises applied for 6 weeks positively affected the balance development in visually impaired individuals aged 10-14 years. No difference was found between the exercise protocols regarding effectiveness, and no improvement was observed in individuals who did not participate in any exercise.