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Öğe Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats(Wiley, 2012) Oguzturk, H.; Ciftci, O.; Aydin, M.; Timurkaan, N.; Beytur, A.; Yilmaz, F.The aim of the present study was to investigate the ameliorative effect of curcumin (CMN) against acute cadmium chloride (CdCl2) toxicity on male reproductive system in rats. CdCl2 is known to be a heavy metal and potential environmental pollutant. For this purpose, 28 rats were equally divided into four groups; the first group was kept as control and given distilled water and corn oil as carrier. In second and third groups, CdCl2 and CMN were administered at the dose with 1 mg kg-1 day-1 and 100 mg kg-1 for 3 days respectively. CdCl2 and CMN were given together at the same doses in the fourth group. It was determined that acute CdCl2 exposure caused a significant reproductive damage via increased oxidative stress (increased TBARS levels and decreased SOD, CAT, GPx and GSH levels), histological alterations (necrosis, oedema etc.) and spermatological damage (decreased sperm motility and sperm concentration and increased abnormal sperm rate) in male rats. However, CMN treatment partially reversed these toxic effects of CdCl2 on the reproductive system. In conclusion, our results show that acute exposure of CdCl2 may lead to infertility, and CMN could prevent and reverse hazardous effects of CdCl2 to some degree. Thus, CMN may be useful for the prevention of CdCl2-induced reproductive damage.Öğe Aminoguanidine prevents testicular damage-induced-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats(Wiley, 2013) Oguz, F.; Ciftci, O.; Aydin, M.; Timurkaan, N.; Beytur, A.; Altintas, R.; Parlakpinar, H.In this study, it was aimed to determinate protective effects of aminoguanidine (AG) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. Thirty-two rats were equally divided into four groups; the first group was kept as control and given corn oil as carrier. In second and third groups, TCDD and AG were orally administered at the dose of 2 mu k g(-1) per week and 100 mg kg(-1) per day for 45 days, respectively. In fourth group, TCDD and AG were given together at the same doses. Although TCDD significantly increased the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx and SOD in rats. On the other hand, AG, given together TCDD, reversed TCDD effects on TBARS SOD, GSH, GPx and CAT. In addition, sperm characteristics negatively affected and histopathological deformation occurred with TCDD exposure. However, AG treatment partly prevented these toxic effects of TCDD on spermatological parameters and histopathological changes. In conclusion, TCDD exposure induces testicular damage (oxidative stress, histopathological damage and sperm parameters), and AG treatment reversed TCDD-induced testicular damage in rats. Thus, AG may be useful for the prevention and treatment of TCDD-induced male infertility problems.Öğe Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury(Wiley, 2016) Ekici, K.; Temelli, O.; Parlakpinar, H.; Samdanci, E.; Polat, A.; Beytur, A.; Tanbek, K.This experimental study was designed to investigate both protective and therapeutic effects of aminoguanidine (AG), on radiotherapy (RT)-induced oxidative stress in kidney and testis. Forty rats were divided into five groups equally as follows: (i) control, (ii) RT, (iii) AG, (iv) AG+RT and (v) RT+AG group. Histopathological findings and biochemical evaluations, including tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), total oxidant status (TOS), total antioxidant capacity, oxidative stress index (OSI), blood urea nitrogen (BUN), serum creatinine (Cr) and testosterone levels, were determined. MDA, TOS and OSI were significantly higher in RT-treated groups, whereas SOD, CAT, GPX and GSH were significantly lower in these groups when compared with the control rats in the kidney and testis tissue. AG treatment significantly decreased MDA, TOS and OSI levels and increased SOD, CAT, GPX and GSH levels, when compared to the RT-treated groups in both kidney and testis tissue. BUN and Cr levels did not change among the groups, whereas testosterone levels were found as reduced in the RT-treated rats. AG treatment significantly augmented these hazardous effects of RT on testis tissue. According to our results, AG has beneficial effects against RT-induced kidney and testis injury.Öğe Beneficial effects of chrysin on the reproductive system of adult male rats(Wiley, 2012) Ciftci, O.; Ozdemir, I.; Aydin, M.; Beytur, A.In this study, the beneficial effect of chrysin, a natural flavonoid currently under investigation due to its important biological activities, on reproductive system of rats was investigated. Rats (n = 16) were divided randomly into two equal groups. Rats in control group were given corn oil as carrier. Chrysin was orally administered at the dose of 50 mg kg-1 per day by gavages, and it was dissolved in corn oil for 60 days. Tissue thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, antioxidant enzyme activity (CAT, SOD and GSH-Px), sperm parameters (motility, concentration and abnormal sperm rate), reproductive organ weight (testes, epididymis, vesicula seminalis, prostate) and serum testosterone levels were determined in the rats. Our results indicated that chrysin significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels, but did not change the formation of TBARS significantly. In addition, sperm motility, sperm concentration and serum testosterone levels significantly increased, whereas abnormal sperm rate significantly decreased with chrysin treatment. In conclusion, it is suggested that treatment with chrysin can positively affect the reproductive system in rats, and it can be used for the treatment of male infertility.Öğe Comparison of results after flouroquinolons and combination therapies in type IIIA chronic prostatitis(Ene Ediciones Sl, 2013) Altintas, R.; Oguz, F.; Beytur, A.; Ediz, C.; Gunes, A.; Ozer, A.Purpose: We investigated retrospectively the clinical outcomes of the patients with type III inflammatory chronic prostatitis, who were treated with fluoroquinolones with and without an alpha-blocker between 2009-2011. Material and methods: Diagnosis was established with medical history (symptoms presented Longer than 3 months within previous 6 months), physical examination, Meares-Stamey test and the questionnaire of the NIH-CPSI. The responses to the treatment were assessed with uroflowmetry test and the questionnaire of NIH-CPSI at initial and after 4 weeks of the treatment. The patients with incomplete data and treatment and who treated with alpha-blockers and/or antibiotics in the period 4 weeks prior to the therapy started in our clinic and had any surgery of lower urinary tract previously were excluded. The patients were classified under 6 groups; group1 = ciprofloxacin, group2 = ofloxacin, group3 = levofloxacin, group4 = ciprofloxacin+tamsulosin, group5 = ofloxacin+tamsulosin, group 6 = levofloxacin+tamsulosin. Wilcoxon Signed Ranks and Kruskal Wallis test were used for comparison of results. Mann Whitney U test with Bonferroni correction made was used as posthoc (P < .05). Results: The median scores of NIH-CPSI decreased significantly in all groups (P < .05). Levofloxacin reduced the median total scores of NIH-CPSI more than ciprofloxacin and ofloxacin monotherapies. The combination therapies were better than antibiotic therapies alone and best result was obtained in levofloxacin + tamsulosin combination. Conclusion: Tamsulosin + fluoroquinolone (especially tamsulosin + levofloxacin) combinations yielded better results in both NIH-CPSI scores and peak flow rates. (C) 2012 AEU. Published by Elsevier Espana, S.L. All rights reserved.Öğe DOES SIMPLE MALROTATION IN KIDNEY AFFECT PERCUTANEOUS NEPHROLITHOTOMY (PNL) OUTCOMES: MULTICENTRE STUDY(Mary Ann Liebert Inc, 2010) Binbay, M.; Stanbulluoglu, O.; Sofikerim, M.; Beytur, A.; Skolarikos, A.; Akman, T.; Huri, E.[Abstract Not Available]Öğe DOES SIMPLE MALROTATION IN KIDNEY AFFECT PERCUTANEOUS NEPHROLITHOTOMY OUTCOMES: A MATCHED PAIR ANALYSIS IN MULTICENTRE STUDY(Elsevier Science Bv, 2010) Binbay, M.; Istanbulluoglu, O.; Sofikerim, M.; Beytur, A.; Skolarikos, A.; Akman, T.; Huri, E.[Abstract Not Available]Öğe The effect of melatonin on acetylsalicylic acid-induced kidney and testis damage(Sage Publications Ltd, 2014) Altintas, R.; Polat, A.; Parlakpinar, H.; Vardi, N.; Beytur, A.; Oguz, F.; Sagir, M.The aim of this study was to evaluate the acute effect of high-dose acetylsalicylic acid (ASA) on kidney and testis, and the potential protective and therapeutic effects of melatonin on ASA-related pathology. A total of 40 rats were randomly divided into the following 5 groups (n = 8): group 1: control, not given any drug; group 2: only 200 mg/kg ASA was given; group 3: 5 mg/kg melatonin was given 45 min before administering 200 mg/kg ASA; group 4: 5 mg/kg melatonin was given 45 min after administering 200 mg/kg ASA; and group 5: only 5 mg/kg melatonin was given. The histopathological changes and the biochemical findings; such as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), and blood urea nitrogen (BUN) as well as serum creatinine (Cr) levels were evaluated. ASA significantly increased MDA levels in both kidney and testis, whereas it significantly decreased the values of SOD, CAT, GPX, and GSH in kidney and CAT levels in testis. Melatonin significantly decreased MDA levels in kidney and ameliorated it in testis, whereas it caused elevation in the levels of antioxidants. BUN and Cr levels were higher after ASA, whereas these levels were diminished after melatonin administration. The improvement obtained by melatonin on ASA-induced histological alterations was more prominent when it was used after ASA in kidney and before ASA in testis. In this study, we demonstrated the beneficial effect of melatonin on high-dose ASA-related pathology of kidney and testis for the first time.Öğe The effects of chronic intraperitoneally infusion of irisin on liver antioxidant balance in rats(Wiley, 2017) Tekin, S.; Cakir, M.; Beytur, A.; Sandal, S.[Abstract Not Available]Öğe EFFECTS OF EXERCISE ON VARICOCELE(Elsevier Science Bv, 2010) Soylemez, H.; Beytur, A.; Oguz, F.; Kahraman, B.; Soylu, A.[Abstract Not Available]Öğe EFFECTS OF MICRONISED PURIFIED FLAVONOID FRACTION AND OXERUTIN ON PAIN, SPERMIOGRAM AND SCROTAL COLOR DOPPLER PARAMETERS IN PATIENTS WITH PAINFUL VARICOCELE(Elsevier Science Bv, 2010) Soylemez, H.; Beytur, A.; Kilic, S.; Oguz, F.; Karademir, I; Koplay, M.[Abstract Not Available]Öğe The effects of montelukast against amikacin-induced acute renal damage(Verduci Publisher, 2012) Kose, E.; Beytur, A.; Dogan, Z.; Ekincioglu, Z.; Vardi, N.; Cinar, K.; Turkoz, Y.Background and Objectives: The therapeutic and protective effects of montelukast against amikacin-induced acute renal damage were investigated. Material and Methods: 35 Wistar albino female rats were divided into 5 groups as follows: Group I: Control; Group II: Control+montelukast; Group III: Amikacin; Group IV: Amikacin+montelukast; Group V: Montelukast+amikacin. At the end of the experiment, the kidney tissues and the blood of rats were collected. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined from kidney tissues. Blood urea nitrogen (BUN), creatinine (Cr), TNF-alpha, and IL-1 beta levels were assessed in the serum. In addition the kidney tissues were examined histologically. Results and Discussion: The MDA, MPO, BUN, and Cr levels of group III significantly increased when compared to groups I and II. These parameters of group IV decreased when compared to group III. In addition, GSH levels significantly increased when compared to the first three groups. MDA, BUN and Cr levels of group V did not reach significant level in comparison with the control group. The most significant histological damage was observed in the group III followed by the groups IV and V. Immunohistochemically, group III showed a significantly increased apoptotic staining. In group IV, it was observed that montelukast treatment reduced the expression of apoptotic cells. Conclusions: Montelukast treatment after amikacin injection could reduce the amikacin-induced kidney damage.Öğe Effects of N-(p-amylcinnamoyl) anthranilic acid (ACA) on various human cancer cell lines(Wiley, 2017) Tekin, S.; Cakir, M.; Beytur, A.; Sandal, S.[Abstract Not Available]Öğe Effects of saxagliptin on human prostate and breast cancer: An in vitro study(Wiley, 2017) Tekin, S.; Beytur, A.; Cakir, M.; Sandal, S.[Abstract Not Available]Öğe A Kidney Transplant Center's Initial Experiences in Eastern Turkey(Elsevier Science Inc, 2012) Piskin, T.; Unal, B.; Koz, S.; Ulutas, O.; Yagmur, J.; Beytur, A.; Kayhan, B.Objectives. Kidney transplantation is the best treatment method associated with improved quality of life and better survival for patients with end-stage renal disease. We started performing kidney transplantations in November 2010. We have performed 19 kidney transplantations so far. Fourteen of these were from living donors and five from deceased donors. Here, we present our initial experiences with 1.4 kidney transplant recipients from living donor kidney transplantations. Materials and methods. All recipients and their donors underwent detailed clinical history and examination. Recipients and their donors were followed in the transplant clinic during hospitalization. Results. The male-to-female ratio was 11:3 in recipients. The mean age of recipients was 27.8 years (range 4-58 years). The number of the related, emotionally related, and unrelated transplantations were 9, 3, 2, respectively. The mean warm ischemic time was 95.7 seconds (range 52-1.68 seconds). Urine output started immediately after vascular anastomosis in all. The mean time of discharge from hospital was postoperative day 8 (range 4-18 days). The mean flow up was 125 days (range 18-210 days). Graft survival was 100% in this period, but one patient died from sepsis after 56 days. No kidney was lost from rejection, technical causes, infection, or recurrent disease. Conclusion. If transplant centers are as equipped and experienced as ours, kidney transplant programs should be started immediately so that they can reduce the number of the patients in waiting list for kidney transplantation.Öğe Lycopene prevents experimental priapism against oxidative and nitrosative damage (vol 18, pg 3320, 2014)(Verduci Publisher, 2021) Ciftci, O.; Oguz, F.; Beytur, A.; Polat, F.; Altintas, R.; Oguzturk, H.[Abstract Not Available]Öğe THE MIDDLE AND EARLY TERM RESULTS OF TRANSOBTURATORY TAPE METHOD(Elsevier Science Bv, 2010) Soylu, A.; Karaca, S.; Beytur, A.; Baydinc, C.[Abstract Not Available]Öğe OUR EXPERIENCES OF HEMOSTASIS WITH PERCUTANEOUS CAUTERIZATION IN PERCUTANEOUS NEPHROLITHOTOMY CASES(Elsevier Science Bv, 2010) Oguz, F.; Soylemez, H.; Beytur, A.; Soylu, A.; Gunes, A.[Abstract Not Available]Öğe OUTCOME OF TIPU TECNIQUE IN CHILDREN AND ADULTS WITH PRIMARY DISTAL AND MIDPENIL HYPOSPADIAS(Elsevier Science Bv, 2010) Soylemez, H.; Oguz, F.; Beytur, A.; Burgu, B.; Soylu, A.[Abstract Not Available]Öğe Protocatechuic acid prevents reproductive damage caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats(Wiley, 2012) Beytur, A.; Ciftci, O.; Aydin, M.; Cakir, O.; Timurkaan, N.; Yilmaz, F.In this study, it was aimed to determinate beneficial effects of protocatechuic acid (PCA) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. For this purpose, 28 rats were equally divided into four groups (control, TCDD 2 mu g kg-1 per week, PCA 100 mg kg-1 per day and TCDD + PCA group), and compounds were orally administered for 45 days. The results indicated that TCDD induced oxidative stress via an increase in thiobarbituric acid-reactive substances levels and a decrease in reduced glutathione, catalase, glutathione peroxidise and SOD levels in male rats. In contrast, PCA treatment prevented toxic effects of TCDD in terms of oxidative stress. Additionally, sperm motility, sperm concentration and serum testosterone levels significantly decreased, and pathologic testicular damage increased with TCDD exposure. However, these effects of TCDD on sperm characteristics, histopathological changes and hormone levels were reversed by PCA treatment. In conclusion, it was found that TCDD exposure induced reproductive toxicity (oxidative, hormonal, histopathological and spermatological alternations) in male rats and PCA treatment could prevent toxic effects of TCDD. Thus, PCA may be useful for the prevention and treatment of reproductive toxicity caused by TCDD.
