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Öğe Adenosine deaminase level in the serum of the patients Toxoplasma gondii seropositive and Giardia intestinalis(Academic Journals, 2009) Karaman, Uelkue; Beytur, Leyla; Kiran, Tugba Raika; Colak, CemilAdenosine deaminase (ADA) is an aminohydrolase making adenosine, deoksiadenozini inozin, and deocsiniozine deaminise irreversibly and plays role in the catabolism of purine nucleotids. Toxoplasma gondii is a zoonoses intracellular parasite that causes infection in animals and humans. This parasite encompasses enzymes that produce free radicals such as superoxide and hydrogen peroxide. In addition, Giardia intestinalis is another parasite that causes irritations in mucosa, over mucus discharge, aggravating former inflammations, and various absorption defects. In the present study, it has been aimed to compare ADA levels between T. gondii seropositive (IgG seropositive but symptomless patients), G. intestinalis positive patients, and control group. Thus, ADA levels between 32 patients being T. gondii seropositive and 29 controls and between 50 patients' G. intestinalis positive and 40 controls have been evaluated. The results were analyzed using independent samples t-test at the level of p < 0.05. According to this, in the statistical comparison between the parameters of patient and control groups, a meaningful decrease could be determined in ADA levels. This situation can be commented in the way that toxoplasmosis infection being inactive does not necessarily cause an increase in T lymphocytes. In addition, this decrease can be due to increasing oxidative stress in parasitic infections.Öğe Adenosine deaminase level in the serum of the patients Toxoplasma gondiiseropositive and Giardia intestinalis(African Journal of Microbiology Research, 2009) Karaman, Ülkü; Beytur, Leyla; Kıran, Tuba; Çolak, CemilAdenosine deaminase (ADA) is an aminohydrolase making adenosine, deoksiadenozini inozin, and deocsiniozine deaminise irreversibly and plays role in the catabolism of purine nucleotids. Toxoplasma gondii is a zoonoses intracellular parasite that causes infection in animals and humans. This parasite encompasses enzymes that produce free radicals such as superoxide and hydrogen peroxide. In addition, Giardia intestinalis is another parasite that causes irritations in mucosa, over mucus discharge, aggravating former inflammations, and various absorption defects. In the present study, it has been aimed to compare ADA levels between T. gondii seropositive (IgG seropositive but symptomless patients), G. intestinalis positive patients, and control group. Thus, ADA levels between 32 patients being T. gondii seropositive and 29 controls and between 50 patients’ G. intestinalis positive and 40 controls have been evaluated. The results were analyzed using independent samples t-test at the level of p < 0.05. According to this, in the statistical comparison between the parameters of patient and control groups, a meaningful decrease could be determined in ADA levels. This situation can be commented in the way that toxoplasmosis infection being inactive does not necessarily cause an increase in T lymphocytes. In addition, this decrease can be due to increasing oxidative stress in parasitic infections. Adenosine deaminase level in the serum of the patients Toxoplasma gondii seropositive and Giardia intestinalis (PDF Download Available). Available from: https://www.researchgate.net/publication/228360278_Adenosine_deaminase_level_in_the_serum_of_the_patients_Toxoplasma_gondii_seropositive_and_Giardia_intestinalis [accessed Jan 16 2018].Öğe Adenosine deaminase level in the serum of the patients Toxoplasma gondiiseropositive and Giardia intestinalis(Afrıcan journal of mıcrobıology research, 2009) Karaman, Ülkü; Beytur, Leyla; Kıran, Tuğba Raika; Çolak, CemilAdenosine deaminase (ADA) is an aminohydrolase making adenosine, deoksiadenozini inozin, and deocsiniozine deaminise irreversibly and plays role in the catabolism of purine nucleotids. Toxoplasma gondii is a zoonoses intracellular parasite that causes infection in animals and humans. This parasite encompasses enzymes that produce free radicals such as superoxide and hydrogen peroxide. In addition, Giardia intestinalis is another parasite that causes irritations in mucosa, over mucus discharge, aggravating former inflammations, and various absorption defects. In the present study, it has been aimed to compare ADA levels between T. gondii seropositive (IgG seropositive but symptomless patients), G. intestinalis positive patients, and control group. Thus, ADA levels between 32 patients being T. gondii seropositive and 29 controls and between 50 patients’ G. intestinalis positive and 40 controls have been evaluated. The results were analyzed using independent samples t-test at the level of p < 0.05. According to this, in the statistical comparison between the parameters of patient and control groups, a meaningful decrease could be determined in ADA levels. This situation can be commented in the way that toxoplasmosis infection being inactive does not necessarily cause an increase in T lymphocytes. In addition, this decrease can be due to increasing oxidative stress in parasitic infections.Öğe Deneysel böbrek iskemi/reperfüzyon hasarı oluşturulan sıçanlarda Myrtenal'in etkilerinin araştırılması(İnönü Üniversitesi, Sağlık Bilimleri Enstitüsü, 2024) Beytur, LeylaAkut böbrek hasar, yoğun bakım ünitelerinde ve vasküler cerrahi operasyonlarda yüksek mortaliteye sebep olan, böbreklerde çok çeşitli fonksiyonel değişikliklere neden olan heterojen bir sendromdur. Myrtenalin (Myrt) çeşitli organ hasarları üzerinde olumlu etkileri olduğu bilinmektedir. Bu çalışma, Myrt'nin renal I/R hasarı üzerindeki etkilerini biyokimyasal ve histolojik düzeyde araştırmak ve anlamak için gerçekleştirilmiştir. Materyal ve metot: Çalışmada 40 adet erkek Sprague Dawley ırkı sıçan kullanılmıştır (n=10). 1. gruptaki hayvanlar sham grubu olup klempleme yapılmamıştır. 2. gruptaki hayvanlara 45 dakika iskemi ve 24 saat reperfüzyon sağlanmıştır. 3. ve 4. gruptaki hayvanlara 9 gün boyunca Myrt'nin iki farklı dozu (40-80 mg/kg) intraperitonal olarak uygulanmış akabinde 45 dakika iskemi ve 24 saat reperfüzyon sağlanmıştır. Deney bitiminde hayvanlar dekapite edilerek kan ve böbrek dokuları histolojik ve biyokimyasal analizler için alınmıştır. Böbrek hasar belirteçleri KIM-1, NGAL; inflamasyon belirteçleri IL-1β ve TNF-α seviyeleri ELISA yöntemiyle; hücre hasarı seviyesi histopatolojik olarak, apoptotik belirteçlerinden kaspaz-3 reaktivitesi immunohistokimyasal yöntemle, oksidatif stres parametrelerinden MDA, SOD, CAT ve GSH seviyeleri biyokimyasal yöntemlerle incelenmiştir. Bulgular: I/R grubundaki serum örneklerindeki BUN ve kreatin seviyelerinin sham grubuna kıyasla belirgin bir artış gösterdiği ve bu artışın Myrt uygulaması ile azaldığı gözlemlendi (p<0.05). Ayrıca, iskemiye bağlı olarak böbrek dokusunda MDA, KIM-1, NGAL düzeylerinin arttığı belirlendi (p<0.05); Myrt uygulamasının ise bu belirteçleri düşürdüğü tespit edildi (p<0.05). I/R sonucu azalan GSH seviyesi ile birlikte SOD ve CAT enzim aktivitelerinin Myrt uygulaması ile arttığı belirlendi (p<0.05). Histolojik analizler, Myrt'nin böbrek hasarını ve Kaspaz-3 immunreaktivitesini azalttığını ortaya koydu (p<0.05). Sonuç: Sonuç olarak, Myrt'nin iskemi-reperfüzyon hasarına karşı koruyucu bir rol oynadığı belirlenmiştir.Öğe Hydatid cyst of the ovary(Int Scientific Literature, Inc, 2010) Karaman, Ulku; Turkmen, Emine Samdanci; Birol, Fatih; Ak, Sibel; Kalayci, Ozlem Tugce; Beytur, LeylaBackground: Echinococcus granulosus is a cestode that causes hydatid cyst disease with its larval form. The disease is often located in the liver; however, it may also be seen in the lungs, kidneys, spleen, brain, bone and heart. Case Report: A 38-year-old woman who had been operated on 4 years ago due to hydatid cyst disease located in the liver, presented at our clinic with pain in the epigastric and inguinal areas. The sonographic, serological and pathological evaluation of the patient leaded us to an uncommon presentation of hydatid cyst lodged in the ovarium. Conclusions: This case is reported to draw attention to unusual localizations of the hydatic cyst.Öğe İnfertilite nedeniyle eş spermi ile uygulanan 78 intrauterin inseminasyon (İUİ) siklusunun sonuçları ve İUİ başarısını etkileyen faktörler: Retrospektif bir çalışma(2005) Kılıç, Süleyman; Beytur, Ali; Altunoluk, Bülent; Beytur, Leyla; Oğuz, Fatih; Atmaca, RuşenÖz: Bu çalışmamızda intrauterin inseminasyon (İUİ) sonuçlarımızın ve sonuçlar üzerine etkili faktörlerin değerlendirilmesini amaçladık. İnfertilite nedeniyle 35 eşte yaklaşık 1 yılda klomifen sitratla over stimulasyonu sonrası uygulanan 78 İUİ siklusunun sonuçları retrospektif analiz edildi. Sperm hazırlamada Discontinuous Gradient Centrifugation (DGC) yöntemi kullanıldı. Erkek-kadın yaşı ve infertilite süresi ortalamaları sırasıyla 29.94±4.72 yıl, 27.46±4.55 yıl ve 63.23±30.88 aydı. On erkek sigara içiyordu. On dört erkek varikoselektomi geçirmişti. Yedi erkekte sol varikosel saptandı. Bütün erkekler normospermikti. Eş başına maksimum 3 İUİ siklusu uygulanmıştı. Eş ve siklus başına gebelik oranları sırasıyla %20 (7/35) ve %8.97 (7/78) idi. Bütün gebelikler normal canlı doğumla sonuçlandı. Üç siklus arasında gebelik oranı açısından fark yoktu. Başarılı grupta erkek ve özellikle kadın yaşı ortalamaları istatistiksel olarak daha düşüktü (sırasıyla p=0.041, p=0.009). DGC sonrası yerinde hareketli sperm yüzdesi dışında bütün semen analizi parametrelerinde oldukça anlamlı düzelme gelişti. Ancak hiçbir parametrenin gebelik üzerinde etkisinin olmadığı saptandı. İnfertilite tipi-süresi ve sigara öyküsünün başarı üzerinde etkisi yoktu. Fizik muayenede varikosel saptanmayanlarda ve önceden başarılı varikoselektomi geçirmiş olanlarda daha yüksek gebelik oranları elde edildi. İnfertil çiftlerde İUİ başarısı üzerinde en etkili faktörler, erkek ve özellikle kadın yaşının genç olmasıdır. Erkekte varikosel olmaması veya başarılı tedavisi başarı üzerinde olumlu etkiler yaratıyor görünmektedir.Öğe Investigation of anticancer effects of Meteorin like protein on different human cancer cell lines(2024) Sekerci, Guldeniz; Beytur, Leyla; Yuksel, Furkan; Tekin, SuatAim: Cancer is one of the biggest health problems threatening humanity, and the fight against cancer continues with different methods worldwide. Despite advances in cancer prevention and treatment, the low success rate and tumor recurrence make the discovery of new alternative agents important. Adipokines are among those known to be associated with cancer. The relationship of the peptide-structured Meteorin like protein (Metrnl), a member of the adipokine family, discovered in 2012, with cancer remains a mystery. This study was conducted to examine the cytotoxic effects of Metrnl on human ovarian, prostate, colon and breast cancer cell lines. Materials and Methods: In the study, ovarian (A2780), human prostate (LNCaP), colon (Caco-2) and breast cancer (MCF-7) cell lines were used. After the cells were incubated with 1, 5, 10, 50, 100 and 200 ng/mL Metrnl for 24 h, the cytotoxicity level was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay method. determined. Comparisons between groups were made with the Kruskal Wallis H-Test. Results: Concentrations of Metrnl significantly reduced cell viability in A2780, LNCaP, Caco-2 and MCF-7 cell lines (p<0.05). Conclusion: These results show that Metrnl may have anticarcinogenic activity on A2780, LNCaP, Caco-2 and MCF-7 cells, but further studies are needed on this subject.Öğe Investigation of demodex SPP on the perinea in women visiting urologyand gynecology policlinics(Healthmed, 2012) Beytur, Leyla; Karaman, Ülkü; Beytur, Ali; Altındağ, Murat; Geçit, İlhan; Özer, Ali; Çolak, CemilÖğe Investigation of Demodex SPP. On the perinea in women visiting urology and gynecology policlinics(Drunpp-Sarajevo, 2012) Beytur, Leyla; Karaman, Ulku; Beytur, Ali; Altindag, Murat; Gecit, Ilhan; Ozer, Ali; Colak, CemilAim: It is reported that species of Demodex can be found in various locations on human body and transmitted via close contact. Types of Demodex are reported to be located in various places of human body. The aim of this study is to investigate the relationship between age and incidence of Demodex spp. among female patients complaining of pruritus in the perinea area. Method: Samples taken from perinea areas of the women using standardized surface skin biopsy (SSSB). Accordingly, samples were obtained using SSSB method from the faces and perinea areas of 431 women aged 18-55, which were then covered with entellan and sent to the parasitological laboratory. Specimens were covered with entellan and evaluated in Parasitology Laboratory. Results: Among the 431 specimens, 21.1% revealed Demodex spp., 1.6% revealed mite, 3.05% revealed Enterobius vermicularis eggs, 0.2% revealed Taenia spp. eggs, and 0.2% revealed Phthirus pubis. Conclusion: It was concluded that it should be taken into consideration that species of Demodex can be found in the women perinea region, thus specimens should be taken from patients consulting with pruritus or allergic reactions in order to diagnose the parasite, and treatment protocol should be planned in this direction. In addition, experimental studies may be planned to investigate the relationship between the parasite intensity in perinea region and pathogenity.Öğe Malatya Devlet hastanesi patoloji laboratuvarına gelen smearlerin enfeksiyon ajanları açısından değerlendirilmesi(2010) Karcı, Erdal; Beytur, Leyla; Karadan, Mesut; Türkmen, Emine; Fırat Yüce, Pınar; Çalık, Sinan; Karaman, ÜlküÖz: Asemtomatik veya semptomatik bulgular veren vajinal enfeksiyonların görülme oranı yüksek olup genellikle parazitler, mantarlar ve bakteriler nedeniyle oluşmaktadırlar. Çalışmada Beydağı Devlet hastanesi patoloji laboratuarına servisit ön tanısı ile alınan smear örneklerinin Papanicolaou (PAPS) boyası ile boyandıktan sonra enfeksiyon ajanları yönünden değerlendirilmesi amaçlanmıştır. Araştırmada 1191 örnek incelenmiş ve %4.8 candida, %7.1 cocobasil, %0.3 Trichomonas vaginalis gözlenmiştir. Olguların %97.5 inde enfeksiyona bağlı lökositoz saptanmıştır. Diğer taraftan hastalardan alınan anemneze göre vajinit enfeksiyonuna neden olabilecek ajanlar hakkında bilgilerinin olmadığı tespit edilmiştir. Hastalar adet düzensizliği, kasık ağrısı ve akıntı şikayeti ile başvurmuş olup enfeksiyon tespit edilenlerin tedavileri eşleri ile birlikte yapılmış ve genel bilgi verilmiştir. Sonuç olarak kadınlarda servisite neden olabilecek etkenler, bulaşma ve korunma yolları ile ilgili halk sağlığı eğitimlerinin verilmesi gerektiği sonucuna varılmıştır.Öğe RESULTS OF 78 INTRAUTERINE INSEMINATION (IUI) CYCLES WITH HUSBAND SPERM IN INFERTILITY AND FACTORS AFFECTING IUI SUCCESS: A RETROSPECTIVE STUDY(Aves, 2005) Kilic, Suleyman; Beytur, Ali; Altunoluk, Bulent; Beytur, Leyla; Oguz, Fatih; Atmaca, RusenIntroduction: Intrauterine insemination (IUI) with or without controlled ovarian hyperstimulation is a widely used therapeutic option for a variety of causes of infertility. Compared to in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), IUI is efficient and more cost-effective than the others for the treatment of unexplained and nonsevere male factor infertility. In this retrospective study, we aimed to determine our IUI outcomes and the variables influencing IUI success. Materials and Methods: To determine the influence of several parameters (age, duration and type of infertility, semen parameters, presence of varicocele, varicocelectomy and smoking histories) on the outcome of IUI in 35 women undergoing ovarian stimulation with clomiphen citrat, a retrospective review of 78 IUI cycles, which were done for the treatment of infertility using fresh husband sperm, was performed for approximately 1 year on data from the IUI program. Results of Pre-IUI evaluations were normal in all women and all men had normal semen analyses results. Discontinuous gradient centrifugation (DGC) with Sil-Select Plus was used for sperm preparation. Maximum number of IUI cycles per couple was three. In statistical analysis, chi(2), Fisher's exact and Mann-Whitney U tests for in-and between-group comparisons and Pearson and Spearman tests for correlation analyses were used. Results: Primary and secondary infertility were determined in 25 and 10 couples, respectively. Fourteen men had varicocelectomy history. Ten men were smoking cigarette. Seven men had left varicocele at physical examination. Means of man and woman age and infertility duration were 29.94+/-4.72 (23-46) years, 27.46+/-4.55 (20-38) years and 63.23+/-30.88 (15-123) months, respectively. The pregnancy rate was 8.97% (7/78) per treatment cycle, 20% (7/35) per patient, 5.71% (2/35) for first cycle, 10.34% (3/29) for second cycle and 14.3% (2/14) for third cycle. All pregnancies were normal. No miscarriage, tubal pregnancy, birth defect and prematurity were observed. Difference between the pregnancy rates of each cycle was statistically insignificant (p=0.697). There were statistically significant negative correlations between the pregnancy rate and mean ages of the men and especially women (p=0.041, p=0.009, respectively). However, no correlation was found between pregnancy rate and infertility duration (p=0.108). DGC procedure increased percents of the sperms moving with a slow, meandering forward progression (grade 2) and in a straight line with high speed (grade 4) and decreased percent of sperms with no movement (grade 0) very significantly, without changing the percent of those with sluggish or nonprogressive movement (grade 1). However no-one of the pre and post-DGC semen analysis parameter was found to have influence on pregnancy rate. Pregnancy rates in the primary and secondary infertile couples were statistically indifferent. Pregnancy rates achieved in patients without varicocele or with a history of successful varicocelectomy were higher than those with untreated varicocele and with a history of unsuccessful varicocelectomy. There was not any statistically significant difference between the pregnancy rates in the patients with and without smoking history. Conclusion: The most significant predictors of success of IUI with fresh husband sperm in infertile couples were age of the woman and man. Absence of varicocele and treatment of it seemed to have affirmative effect on pregnancy rate.Öğe Risk factors of hepatitis B virus infection in Turkey: A population-based, case-control study(Baqiyatallah Research Center, 2011) Ozer, Ali; Yakupogullari, Yusuf; Beytur, Ali; Beytur, Leyla; Koroglu, Mehmet; Salman, Feyza; Aydogan, FisunBackground: Although the World Health Organization (WHO) classifies Turkey as a country with a moderate-high prevalence of hepatitis B virus (HBV) infection, there is little data on HBV transmission in this country. Objectives: To identify risk factors for HBV infection, we performed a retrospective case-control study between January 2007 and December 2009. Patients and Methods: Acute HBV patients and population controls were selected, and data from these groups were analyzed by logistic regression. method. Results: The study included 129 patients with acute HBV infection and 219 controls. Hemodialysis (OR:8.2, 95% Cl: 4.17-16.61, p < 0.05), having an HBsAg (+) spouse (OR: 4.3, 95% Cl:2.17-8.53, p < 0.05), living with an HBsAg (+) parent(s) (OR: 3.25, 95% CI:1.73-6.12, p < 0.05), and being male (OR: 1.34, 95% Cl: 0.82-2.21, p < 0.05) were independent risk factors that were potentially associated with HBV infection. More than one-third of female patients had a significantly higher risk (34.5% vs. 13.5%, p < 0.05) of acquiring HBV from their sexual partners. Hemodialysis was the most frequent risk factor (46.9% vs. 20%, x(2) = 10.45, p < 0.05) for patients aged over 31 years, and living with HBsAg (+) parents was a significantly higher risk factor (28.8% vs. 10.2%, x(2) = 6.15, p < 0.05) that is more likely to lead to HBVin patients aged under 30 years. Conclusions: This study suggests that persons in Turkey who undergo hemodialysis are at high risk for acquiring HBV. Having an HBsAg (+) spouse (sexual transmission) or living with HBsAg (+) parents (household transmission) are significant risk factors for HBV transmission. Vaccination appears to be better preventive method against the spread of HBV. (C) 2011 Kowsar M.P.Co. All rights reserved.
