Yazar "Bilgic, Y." seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The Acute Effect of Humic Acid on Iron Accumulation in Rats(Humana Press Inc, 2016) Cagin, Yasir Furkan; Sahin, N.; Polat, A.; Erdogan, M. A.; Atayan, Y.; Eyol, E.; Bilgic, Y.Free iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and the histopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.Öğe Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats(Sage Publications Inc, 2015) Bilgic, Y.; Harputluoglu, M. M. M.; Kutlu, O.; Demirel, U.; Gul, M.; Otlu, B.; Temel, I.Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.Öğe Endoscopic treatment of biliary complications after duct-to-duct biliary anastomosis in pediatric liver transplantation(Springer, 2019) Harputluoglu, M.; Demirel, U.; Caliskan, A. R.; Selimoglu, A.; Bilgic, Y.; Aladag, M.; Erdogan, M. A.Background Studies reporting outcomes of endoscopic treatment methods in children who underwent liver transplantation (LT) is very limited. We present our outcomes, as a high-volume transplant center where endoscopic methods are preferred as the first choice in the treatment of biliary complications in children. Methods Patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) as the first treatment approach for biliary complications after LT between 2005 and 2017 were included. Clinical data included patient demographics, ERCP indications (stricture or leak), and treatment outcomes, including the need for percutaneous and surgical intervention. Results ERCP was performed in 49 patients who had a duct-to-duct anastomosis (38 living donor liver transplantation (LDLT), 11 deceased donor liver transplantation (DDLT)). The most common biliary complication was stricture. Our endoscopic success rate was 66.7% (18/27) and 75% (6/8) in LDLT and DDLT patients with stricture (p > 0.05), respectively. While our endoscopic success rate was 75% (3/4) in patients with leak alone after LDLT, it was 25% (1/4) in patients with leak and stricture in this group. The endoscopic success rate was 50% in two patients who had leak alone after DDLT. Conclusions ERCP should be considered as a preferential treatment option for the management of biliary complications in pediatric liver transplant patients with duct-to-duct anastomosis, as in adults.Öğe Endoscopic treatment of biliary complications after living donor liver transplantation in a high volume transplant center in Turkey; a single-center experience(Univ Catholique Louvain-Ucl, 2018) Harputluoglu, M.; Aladag, M.; Demirel, U.; Bilgic, Y.; Dertli, R.; Erdogan, M. A.; Karincaoglu, M.Background and aim : Biliary complications are an important cause of mortality and morbidity after living donor liver transplantation (LDLT). We present our endoscopic treatment results after LDLT as a single center with high volume. Methods : Patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) alter LDLT between 2005 and 2015 were included. Clinical data included patient demographics. ERCP indications (stricture or leak), and treatment outcomes, including need for percutaneous and surgical interventions. Results : ERCP was performed in 446 (39.2%) patients with duct-to-duct anastomosis of 1136 LDLT patients. The most common biliary complication was stricture +/- stone (70.6%, 315/446). Stricture and leak occurred in 60 (13.4%) patients. Only binary leak was found in 40 (8.9%) patients. Our endoscopic treatment success rate in patients with biliary stricture after LDLT was 65.1%. Overall endoscopic success rates in our patients were 55.0% in patients with both leak and stricture, and only leak. In all, our percutaneous transhepatic biliary interventions (P'f BI) and ERCP success rate was 90.6% in patients with biliary complications after LDLT. Conclusions : Endoscopic treatments are highly effective for biliary complications after LDLT. Effective use of percutaneous interventions in collaboration with endoscopic treatments significantly reduces the need for surgical treatment.Öğe Endoscopic treatment of biliary complications after pediatric liver transplantation in a high volume transplant center in Turkey(Lippincott Williams & Wilkins, 2018) Harputluoglu, M. M. M.; Aladag, M.; Bilgic, Y.; Erdogan, M. A.; Caliskan, A. R.; Selimoglu, A.; Demirel, U.[Abstract Not Available]Öğe Endosopic treatment of biliary complications after living donor liver transplantation(Lippincott Williams & Wilkins, 2022) Ataman, E.; Harputluoglu, M. M.; Bilgic, Y.; Erdogan, M. A.; Cagin, Y. F.; Saglam, O.; Orman, I.[Abstract Not Available]Öğe Long-term outcomes of liver transplantation for primary sclerosing cholangitis(Lippincott Williams & Wilkins, 2022) Harputluoglu, M. M.; Calgin, M. Z.; Bilgic, Y.; Kutlu, R.; Yilmaz, S.[Abstract Not Available]Öğe Management of wet ascitic type of peritoneal tuberculosis: single center experience(Verduci Publisher, 2023) Gonultas, F.; Akbulut, S.; Sarici, K. B.; Toprak, S.; Kilci, B.; Bilgic, Y.; Kose, A.OBJECTIVE: We aimed to present our experience with the management of 17 patients with ascites who underwent diagnostic laparoscopy or laparotomy, and histologic con-firmation of wet ascitic type of peritoneal tuber-culosis (TB).PATIENTS AND METHODS: Between Janu-ary 2008 and March 2019, 17 patients whose as -cites were investigated by a gastroenterologist and who were thought to have non-cirrhotic as -cites were referred to our Surgery clinic for peri-toneal biopsy. The clinical, biochemical, radio-logical, microbiological, and histopathological data of the patients who underwent diagnostic laparoscopy or laparotomy were analyzed ret-rospectively. Histopathological examination of peritoneal tissue samples in hematoxylin-eo-sin-stained preparations revealed necrotiz-ing granulomatous inflammation with caseous necrosis and Langhans type giant cells. Eh-rlich-Ziehl-Neelsen (EZN) staining was studied with the suspicion of TB. Acid-fast bacilli (AFB) were detected in EZN stained slide. Histopatho-logical findings were also considered.RESULTS: Seventeen patients aged 18 to 64 years were included in this study. The most common symptoms were ascites and abdomi-nal distention, weight loss, night sweats, fever and diarrhea. Radiological examination revealed peritoneal thickening, ascites, omental cacking, and diffuse lymphadenopathy. Histopathologi-cally, necrotizing granulomatous peritonitis con-sistent with peritoneal TB were detected. While direct laparoscopy was preferred in sixteen pa-tients, laparotomy was preferred in the remain-ing one due to previous surgical procedures. However, seven were converted to open laparot-omy.CONCLUSIONS: Diagnosis of abdominal TB requires high index of suspicion, and the treat-ment should be prompt to reduce the morbidity and mortality associated with delay in treatment.Öğe Retrospective analysis of liver transplant patients for autoimmune hepatitis(Lippincott Williams & Wilkins, 2022) Saglam, O.; Harputluoglu, M. M. M.; Ataman, E.; Bilgic, Y.; Yildirim, O.; Cagin, Y. F.; Seckin, Y.[Abstract Not Available]
