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    Antioxidant Effect of Apelin on Renal Iischemia/Reperfusion Damage
    (Wiley-Blackwell, 2015) Bircan, Burak; Cakir, Murat; Kirbag, Sevda
    [Abstract Not Available]
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    Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats
    (Taylor & Francis Ltd, 2016) Bircan, Burak; Cakir, Murat; Kirbag, Sevda; Gul, Huseyin Fatih
    Apelin is a peptide hormone defined as a ligand for G-protein clamped receptor (APJ) receptor. It is indicated in the literature both apelin and APJ are synthesized on the peripheral tissues including the renal tissues. Which roles does the apelin play on the renal tissue has not been completely illuminated yet. This study is designed to determine the possible protective effect of apelin-13 on the kidney I/R injury. Adult male Sprague-Dawley rats were used in this study. In the sham group, right kidneys of the animals were dissected. In the I/R group, right kidney was dissected and ischemia of 45min was performed, and then reperfusion was applied for 3h. In the treatment groups, three different doses of apelin were injected at the beginning of the ischemia unlike the I/R group. BUN, Cre, Na, K, Cl, total protein and albumin from serum samples were determined and TNF-, IL-1, IL-6, TAS and TOS parameters were read with ELISA reader. MDA, SOD, CAT and GSH-Px enzyme activations from renal tissues were measured. In comparison with the sham and I/R groups, while the serum BUN, CRE, CI and TNF- levels showed an increase in the groups on which the apelin-13 was applied, Na, total protein, albumin, TAS levels decreased. Serum TOS level of other groups showed an increase by comparison with the sham group. Our results showed that apelin-13 applied after I/R increased the antioxidant enzyme activity in a dose dependent manner, prevented the lipid oxidation and improved the renal functions.
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    Effect of Apelin-13 on Liver Damage Following the Renal Ischemia/Reperfusion
    (Wiley-Blackwell, 2015) Bircan, Burak; Cakir, Murat; Kirbag, Sevda
    [Abstract Not Available]
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    The Effect of Capsaicin on Oxidative Stress Parameters in Kidney in Sepsis Model Induced by Cecal Ligation and Puncture
    (Wiley, 2023) Firat, Semanur; Bircan, Burak; Cakir, Murat; Sekerci, Guldeniz; Oz, Samet
    [Abstract Not Available]
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    The Effect of TRPA1 Channel Agonist ASP7663 and Antagonist HC-030031 on Oxidative Stress Parameters in Renal Ischemia Reperfusion in Rats
    (Wiley, 2023) Firat, Semanur; Sekerci, Guldeniz; Cakir, Murat; Bircan, Burak; Oz, Samet
    [Abstract Not Available]
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    Investigating Inhibitory Effects of Punica granatum Fruit Extracts on Lipid Peroxidation in the Fenton Reagent Environment
    (Asian Journal Of Chemistry, 2012) Ozsahin, Ayse Dilek; Kirecci, Oguz Ayhan; Yilmaz, Okkes; Erden, Yavuz; Bircan, Burak; Karaboga, Zeynep
    In this study, it is aimed to find antioxidant activity of methanolic extract of Punica granatum fruit, by determining alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical scavenging property and also by determining the capacity to prevent the formation of lipid peroxidation which is found in in-vitro environment that soybean and corn oils are found. The capacity of preventing lipid peroxidation was analyzed in an in vitro environment that oil samples were existed by evaporating methanol phase of extracts. In the experiment, the groups were formed as control group e.g., Fenton reactive, Pomegranate extract + Fenton reactive. It was observed that the lipid peroxidation level formed on the oils had increased at a significant level when compared to Fenton reactive groups according to the control group. When the extract groups are compared (to each other) according to the Fenton reactive group, it was detected that lipid peroxidation level had significantly decreased (p < 0.0001). According to the scavenging activity of alpha,alpha-diphenyl-beta-picrylhydrazyl radical, it was determined that the pomegranate extracts were effective at their highest level at 250-500 mu L (p < 0.0001). It was concluded that Punica granatum effectively decreases the lipid peroxidation level, neutralizes the alpha,alpha-diphenyl-beta-picrylhydrazyl free radical and has a characteristic of conserving the fatty acid content.