Yazar "Boulcina, Raouf" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    New silver N-heterocyclic carbenes complexes: Synthesis, molecular docking study and biological activities evaluation as cholinesterase inhibitors and antimicrobials
    (Elsevier, 2021) Lasmari, Sarra; Ikhlef, Sofiane; Boulcina, Raouf; Mokrani, El Hassen; Bensouici, Chawki; Gurbuz, Nevin; Dundar, Muhmammed
    We focused our study for the conception and the synthesis of a new series of Silver (I) N-heterocyclic carbene complexes which were obtained from the corresponding N-heterocyclic carbene (NHC) precursors and their unsymmetrical benzimidazolium salts. These new Ag-NHC complexes were screened for their antibacterial, antifungal, and anti-cholinesterase activities. The biological activities of synthesized products were compared with standard drugs. N-heterocyclic carbenes 2a-f and complexes 3a-f exhibited moderate antibacterial and antifungal activities. The results proved that the compounds indicated moderate to excellent activity against both AChE and BuChE. It was found that most of the complexes displayed good AChE and BuChE inhibitory activities. In particular, compounds 3c and 3e were the most potent inhibitors in the series with IC50 values of 8.56 +/- 1.17 mu M and 5.05 +/- 0.30 mu M against AChE and BChE, respectively. Docking studies revealed that compounds 3c and 3e bind manly to the catalytic anionic site (CAS) of the AChE, and BChE respectively. (C) 2021 Elsevier B.V. All rights reserved.
  • Küçük Resim Yok
    Öğe
    New Silver N-Heterocyclic Carbenes Complexes: Synthesis, Molecular Docking Study and Biological Activities Evaluation as cholinesterase inhibitors and antimicrobials (vol 1238, 130399, 2021)
    (Elsevier, 2021) Lasmari, Sarra; Ikhlef, Sofiane; Boulcina, Raouf; Mokrani, El Hassen; Bensouici, Chawki; Gurbuz, Nevin; Dundar, Muhmammed
    [Abstract Not Available]
  • Küçük Resim Yok
    Öğe
    Synthesis of [PdBr2(benzimidazole-2-ylidene)(pyridine)] complexes and their catalytic activity in the direct C-H bond activation of 2-substituted heterocycles
    (Pergamon-Elsevier Science Ltd, 2021) Lasmari, Sarra; Gurbuz, Nevin; Boulcina, Raouf; Ozdemir, Namik; Ozdemir, Ismail
    A series of unsymmetrical 1,3-disubstituted benzimidazolium chlorides, 2a-f, having two nitrogen atoms substituted by various alkyl groups were synthesized as N-heterocyclic carbene (NHC) precursors in high yields. The benzimidazolium salts are readily converted into the corresponding PEPPSI-type palladium-NHC complexes 3a-f (PEPPSI = pyridine-enhanced precatalyst preparation, stabilization and initiation). The structures of all the compounds have been characterized by H-1 NMR, C-13 NMR and IR spectroscopy, as well as the X-ray diffraction technique (3a, 3d and 3e), which support the proposed structures. Next, the palladium-NHC-PEPPSI complexes were used as catalysts in the direct C(5)-arylation of 2-acetyl furan and 2-acetylthiophene with various aryl bromides. These complexes exhibited moderate to high catalytic activities and gave C-H activation selectively at the C(5)-position of 2-acetylfuran and 2-acetylthiophene. (c) 2021 Elsevier Ltd. All rights reserved.