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    An autopsy case of disseminated angioinvasive aspergillosis
    (Egyptian Forensic Medicine Authority, 2012) Samdanci E.T.; Ak S.; Bozdag Z.; Sayin S.
    Angioinvasive aspergillosis is a rare but potentially devastating disease especially in immunocompromised hosts. However diabetes mellitus is one of the chronic conditions that leads to immunosufficiency in patients, it is rarely reported in such cases. Here we aimed to present an autopsy case of disseminated angioinvasive aspergillosis with diabetes mellitus and discuss the other possible underlying reasons for this situation. A 52. year old man with diabetes mellitus operated for the fracture of his L1 vertebra and tibia due to falling down from the third floor of a building. After his death on postoperative 34th day, histopathologic examination of the tissue samples presented multiple hyphae having dichotomous branching at 45-degree angles in infiltration areas. In conclusion, in long-term hospitalized patients with diabetes mellitus, fungal infections should be taken into account and an empirical antifungal therapy is recommended. Besides, sterilization procedures should be obeyed in order to prevent infectious diseases. © 2012 Forensic Medicine Authority.
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    Investigation of the Effect of Local and Systemic Preoperative Dexamethasone Application on Bone Tissue Healing in Mandibular Bone Defects
    (Lippincott Williams and Wilkins, 2024) Yavuz G.Y.; Keskinruzgar A.; Bozdag Z.; Bayazit S.
    Objectives: The aim of this study was to investigate the effect of locally and systemically delivered single-dose corticosteroid injections on bone tissue. Study Design: A total of 84 Wistar albino rats were divided into 2 groups as local and systemic injection groups, and 2 groups as control and experiment among themselves. Before the procedure, dexamethasone was given to the experimental group and physiological saline was given to the control group. A defect was created in the jawbone. It was sacrificed on the third, seventh, and 40th days. The mandible bones of the sacrificed rats were removed and the healing of the bone tissue was examined histopathologically. Results: No significant difference was observed in the tissue sections of the subjects sacrificed after 40 days. However, the increase in fibroblastic connective tissue and the number of osteoblasts were less in the experimental local groups that were sacrificed after 7 days compared with the control groups (P=0.040 and 0.041). Again, it was determined that there was a statistically significant decrease in the experimental local group compared with the experimental systemic group (P=0.040 and 0.004). Conclusions: It can be said that single-dose corticosteroid applications cause a delay in bone healing in the early period. © 2024 by Mutaz B. Habal, MD.