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    Can the ADO Index Be Used as a Predictor of Mortality from COVID-19 in Patients with COPD?
    (Dove Medical Press Ltd, 2024) Yazar, Esra Ertan; Gunluoglu, Gulsah; Yigitbas, Burcu Arpinar; Calikoglu, Mukadder; Gulbas, Gazi; Sarioglu, Nurhan; Bozkus, Fulsen
    Background: Several studies have shown that the risk of mortality due to COVID-19 is high in patients with COPD. However, evidence on factors predicting mortality is limited. Research Question: Are there any useful markers to predict mortality in COVID-19 patients with COPD?. Study Design and Methods: A total of 689 patients were included in this study from the COPET study, a national multicenter observational study investigating COPD phenotypes consisting of patients who were followed up with a spirometry-confirmed COPD diagnosis. Patients were also retrospectively examined in terms of COVID-19 and their outcomes. Results: Among the study patients, 105 were diagnosed with PCR-positive COVID-19, and 19 of them died. Body mass index (p= 0.01) and ADO (age, dyspnoea, airflow obstruction) index (p= 0.01) were higher, whereas predicted FEV1 (p< 0.001) and eosinophil count (p= 0.003) were lower in patients who died of COVID-19. Each 0.755 unit increase in the ADO index increased the risk of death by 2.12 times, and each 0.007 unit increase in the eosinophil count decreased the risk of death by 1.007 times. The optimum cut-off ADO score of 3.5 was diagnostic with 94% sensitivity and 40% specificity in predicting mortality. Interpretation: Our study suggested that the ADO index recorded in the stable period in patients with COPD makes a modest contribution to the prediction of mortality due to COVID-19. Further studies are needed to validate the use of the ADO index in estimating mortality in both COVID-19 and other viral respiratory infections in patients with COPD.
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    Disease history of patients with COPD
    (Kare Publ, 2022) Suerdem, Mecit; Sanoglu, Nurhan; Ogan, Nalan; Arslan, Sertac; Yildirim, Guifem; Diken, Oziem Ercen; Bozkus, Fulsen
    BACKGROUND AND AIM: This study aimed to obtain real-life data of patients diagnosed with chronic obstructive pulmonary disease (COPD) at least one year ago, including smoking history, inhaler device training, and the number of exacerbations. METHODS: This study was planned as a nationwide, prospective, observational, multicenter, and noninterventional study, and web-based electronic case forms were used to register the patients. RESULTS: A total of 460 patients from 11 centers were included, of whom 88.3% were males. Of the total patients, 137 (29.8%) were current smokers, and 292 (63.5%) were ex-smokers. One hundred twenty-four (29.6%) patients did not receive inhaler device training. Repeated inhaler device training in the follow-up visits was not performed in 255 (60.8%) patients. Of the total participants, 187 (41.0%) reported no exacerbations in the previous year. The mean number of exacerbations per person over the previous year was 1.19. The annual rates of influenza and pneumococcal vaccines were 34.8% and 4.2%, respectively. CONCLUSIONS: Patients should be trained more efficiently in the risks of COPD, use of inhaler devices, exacerbations, and improving quality of life.