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Öğe Altered isotope charge distribution of acetylcholine neurotransmitter and Myasthenia Gravis(Churchill Livingstone, 2016) Bayri, A.; Unal, S.; Altin, S.; Bulut, F.; Dayanc, B. E.Acetylcholine (ACh) is a central neurotransmitter that is used for signal transmission among neurons. For signal transmission in neurons, a neurotransmitter must bind to its receptor in order to produce an action potential. It is known that in Myasthenia Gravis (MG) cases, autoantibodies could block this binding. In the future, the treatment of MG could be achieved via modulation of molecular interaction between ACh and acetylcholine receptor (AChR). This study suggests that if an atom on a ligand (i.e. a neurotransmitter) is replaced with its isotope, it may cause charge redistribution such as that the binding between ligand and its receptor may be improved. Hence suggesting that with replacement of atoms with their isotopes in any biologically important ligand could alter its affinity towards its corresponding receptor, which would have a wide array of applications in medicine. (C) 2016 Elsevier Ltd. All rights reserved.Öğe Chebyshev Wavelet Method for Numerical Solutions of Coupled Burgers' Equation(Hacettepe Univ, Fac Sci, 2019) Oruc, O.; Bulut, F.; Esen, A.This paper deals with the numerical solutions of one dimensional time dependent coupled Burgers' equation with suitable initial and boundary conditions by using Chebyshev wavelets in collaboration with a collocation method. The proposed method converts coupled Burgers' equations into system of algebraic equations by aid of the Chebyshev wavelets and their integrals which can be solved easily with a solver. Benchmarking of the proposed method with exact solution and other known methods already exist in the literature is made by three test problems. The feasibility of the proposed method is demonstrated by test problems and indicates that the proposed method gives accurate results in short cpu times. Computer simulations show that the proposed method is computationally cheap, fast and quite good even in the case of less number of collocation points.Öğe Chondrosarcoma of the nasal septum a case report(Kulak Burun Boğaz İhtisas Dergisi, 2004) Bulut, F.; Kızılay, Ahmet; Aydın, Nasuhi EnginThe nasal septum is a particularly rare site of origin of a chondrosarcoma. A 55-year-old man presented with complaints of nasal obstruction and anosmia of one year duration. A fragile mass was detected in the left nasal cavity. Computed tomography showed a large hypodense mass with scattered calcifications, eroding both ethmoid sinuses and extending to the left orbit. Following a biopsy, the tumor was resected via a lateral rhinotomy approach. No evidence for recurrent disease was detected during a three-year follow-up period. Although unusual in the nasal septum, chondrosarcoma must be considered in the differential diagnosis of calcified intranasal masses.Öğe Does smoking increase the anesthetic requirement?(2019) Esen, A.; Bulut, F.; Oruç, Ö.Abstract: Background/aim: To examine the effects of active and passive smoking on perioperative anesthetic and analgesic consumption. Materials and methods: Patients were divided into three groups: group S, smokers; group PS, passive smokers; and group NS, individuals who did not have a history of smoking and were not exposed to smoke. All patients underwent the standard total intravenous anesthesia method. The primary endpoint of this study was determination of the total amount of propofol and remifentanil consumed. Results: The amount of propofol used in induction of anesthesia was significantly higher in group S compared to groups PS and NS. Moreover, the total consumption of propofol was significantly higher in group S compared to groups PS and NS. The total propofol consumption of group PS was significantly higher than that of group NS (P = 0.00). Analysis of total remifentanil consumption showed that remifentanil use was significantly higher in group S compared to group NS (P = 0.00). Conclusion: The amount of the anesthetic required to ensure equal anesthetic depth in similar surgeries was higher in active smokers and passive smokers compared to nonsmokers.Öğe A Haar wavelet-finite difference hybrid method for the numerical solution of the modified Burgers' equation(Springer, 2015) Oruc, O.; Bulut, F.; Esen, A.In this paper, we investigate the numerical solutions of one dimensional modified Burgers' equation with the help of Haar wavelet method. In the solution process, the time derivative is discretized by finite difference, the nonlinear term is linearized by a linearization technique and the spatial discretization is made by Haar wavelets. The proposed method has been tested by three test problems. The obtained numerical results are compared with the exact ones and those already exist in the literature. Also, the calculated numerical solutions are drawn graphically. Computer simulations show that the presented method is computationally cheap, fast, reliable and quite good even in the case of small number of grid points.Öğe Numerical solution of the KdV equation by Haar wavelet method(Indian Acad Sciences, 2016) Oruc, O.; Bulut, F.; Esen, A.This paper aims to get numerical solutions of one-dimensional KdV equation by Haar wavelet method in which temporal variable is expanded by Taylor series and spatial variables are expanded with Haar wavelets. The performance of the proposed method is measured by four different problems. The obtained numerical results are compared with the exact solutions and numerical results produced by other methods in the literature. The comparison of the results indicate that the proposed method not only gives satisfactory results but also do not need large amount of CPU time. Error analysis of the proposed method is also investigated.Öğe Numerical Solutions of Fractional System of Partial Differential Equations By Haar Wavelets(Tech Science Press, 2015) Bulut, F.; Oruc, O.; Esen, A.In this paper, time fractional one dimensional coupled KdV and coupled modified KdV equations are solved numerically by Haar wavelet method. Proposed method is new in the sense that it doesn't use fractional order Haar operational matrices. In the proposed method L1 discretization formula is used for time discretization where fractional derivatives are Caputo derivative and spatial discretization is made by Haar wavelets. L-2 and L-infinity error norms for various initial and boundary conditions are used for testing accuracy of the proposed method when exact solutions are known. Numerical results which produced by the proposed method for the problems under consideration confirm the feasibility of Haar wavelet method combined with L1 discretization formula.Öğe Numerical Solutions of Regularized Long Wave Equation By Haar Wavelet Method(Springer Basel Ag, 2016) Oruc, O.; Bulut, F.; Esen, A.In this paper, we are going to investigate numerical solutions of the regularized long wave (RLW) equation by using Haar wavelet (HW), combined with finite difference method. The motion of a single solitary wave, interaction of two solitary waves, Maxwellian initial condition and wave undulation are our test problems for measuring performance of the proposed method. The results of computations are compared with exact solutions and those already published. and error norms and the numerical conservation laws are computed for discussing the accuracy and efficiency of the proposed method.Öğe A Numerical Treatment Based on Haar Wavelets for Coupled KdV Equation(2017) Oruç, Ö.; Bulut, F.; Esen, A.Abstract:In this paper, numerical solutions of one dimensional coupled KdV equation has been investigated by Haar Wavelet method. Time derivatives given in this equation are discretized by finite differences and nonlinear terms appearing in the equations are linearized by some linearization techniques and space derivatives are discretized by Haar wavelets. For examining performance of the proposed method, single soliton solution and conserved quantities of some test problems are used. Also error analysis of numerical scheme is investigated and numerical results are compared with some results already existing in the literatureÖğe The production of a low cost printing device for energy storage systems and the application for supercapacitors(Elsevier, 2019) Altin, S.; Bulut, F.; Yasar, S.The miniature printing device was produced by using 3- axis stage and the stage was controlled by microprocessor. The ink section was fixed at the top of the stage and the substrate was mobile in the system. The ink was produced by using graphene as an electrode material and it was printed on a non-conductive substrate. It was used a 1M KOH for an electrolyte material and electrochemical performance of the device were investigated. It was obtained that the first cycle specific capacity of the device is 102 F/g and it was decreased to 88 F/g for 1000 cycle. So it may say that the device is very useful for energy storage device and it is cheaper than that of the commercial systems.Öğe A unified approach for the numerical solution of time fractional Burgers' type equations(Springer Heidelberg, 2016) Esen, A.; Bulut, F.; Oruc, O.In this paper, a relatively new approach is devised for obtaining approximate solution of time fractional partial differential equations. Time fractional diffusion equation and time fractional Burgers-Fisher equation are solved with Haar wavelet method where fractional derivatives are Caputo derivative. Time discretization of the problems made by L1 discretization formula and space derivatives discretized by Haar series. L-2 and L-infinity error norms are used for measuring accuracy of the proposed method. Numerical results obtained with proposed method compared with exact solutions as well as with available results from the literature. The numerical results verify the feasibility of Haar wavelet combined with L1 discretization formula for the considered problems.
