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    Investigation of Antimicrobial Activities and Molecular Docking Studies of Synthesized Sulfonamide Compounds
    (Springer, 2023) Ozbey, G.; Tanriverdi, E. S.; Senkal, B. F.; Korkmaz, B.; Erkan, S.; Bulut, N.; Zigo, F.
    Sulfonamides are commonly used worldwide. In this study, several sulfonamide compounds such as N-(4-acetylphenyl)-4-methylbenzenesulfonamide (PSASF), N-(3-acetylphenyl)-4-methylbenzenesulfonamide (PSASF-1), 1-tosyl-1H-imidazole (PSASF-x), 4-methyl-N-(pyridin-4-yl) benzenesulfonamide (PSASF-2), and 1-ethyl-4-tosylpiperazine (PSASF-3) have been synthesized, with antibacterial activities against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 29213 have been evaluated. Antibacterial properties of drugs were studied in depth using molecular docking research. In addition, the synthesized compounds were characterized using spectral analysis. Antibacterial activities of synthesized derivates were determined against E. coli, P. aeruginosa, and S. aureus with minimum inhibitory concentration (MIC) by using the broth microdilution method. All prepared compounds exhibited significant antibacterial activity against S. aureus, E. coli, and P. aeruginosa. The MIC value for E. coli and P. aeruginosa was determined as 256 mu g/mL. MIC against S. aureus was observed to be 256 and 512 mu g/mL for the PSASF compound and the other compounds respectively. Results of the current study revealed that four of the five compounds had weaker antibacterial activity against S. aureus at a concentration of 512 mu g/mL. However, the MIC values from our experiments are significantly higher in comparison with the reference drugs such as amoxicillin, ciprofloxacin, meropenem, and vancomycin in E. coli and S. aureus. On the other hand, in a comparison of the synthesized compounds with reference drugs in P. aeruginosa, no statistical difference was demonstrated. Antibacterial activity of the produced derivates was likewise an agreement with regard to the molecular docking and the laboratory results.
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    The Effect of Sevoflurane and Desflurane on Clara Cell Protein in the Lung in Liver Transplant Donors
    (Wolters Kluwer Medknow Publications, 2026) Teker, N.; Ucar, M.; Bulut, N.; Teker, A. B.; Colak, Y. Z.; Demiroz, D.; Erdogan, M. A.
    Background:Inhalation anesthetics are known to have different effects on the respiratory system than anesthesia. Clara cells in the respiratory epithelium, which protect the lungs, play a role in the detoxification of xenobiotics and oxidant gases, control of inflammation, mucociliary clearance of environmental agents, and proliferation and differentiation of ciliated cells. Serum concentrations of Clara Cell Protein (CC16) have been used as indicators of lung injury in various acute and chronic lung diseases.Aim:In this study, we aimed to investigate the effects of sevoflurane and desflurane inhalation anesthetics on CC16 in liver transplant donors scheduled for hepatectomy.Methods:A total of 75 patients aged 18-65 years, ASA I-II, and liver transplant donors undergoing right lobe hepatectomy were enrolled in this prospective, randomized clinical trial. Patients were evaluated in three groups: Group sevoflurane (Group S), group desflurane(Group D), and group control(Group K). Anesthesia was induced with 2 mg/kg propofol and 1 mu g/kg remifentanil in all groups and muscle relaxation was achieved with 0.6 mg/kg rocuronium. In addition to the FiO2:0.4 air/O2 mixture, Group S was ventilated with 1-2% sevoflurane and Group D was ventilated with 6-8% desflurane. Group K: Anesthesia maintenance was adjusted to 10 mg/kg/h for the first 10 min, 8 mg/kg/h for the next 10 min, 6 mg/kg/h propofol infusion, and 3 mu g/kg/h remifantanil. Patients in this group were ventilated with an air/O2 mixture with an FiO2 of 0.4, and inhalation anesthetics were not used. Blood samples for CC16 were obtained from all patients preoperatively, intraoperatively at 1 hour and immediately after the surgical procedure was completed.Results:There was a significant difference between the groups in terms of preoperative, 1st hour and pre-extubation CC16 values. CC16, 1st hour and pre-extubation CC16 values were significantly lower in Group S than in Group K.Conclusion:When used at clinical doses, sevoflurane and desflurane had no adverse effects on CC16, an important marker of acute airway injury, in healthy lungs. We found that sevoflurane decreased the CC16' level more than desflurane.