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Öğe The effect of abdominal surgery on serum CA-125 levels(2000) Sari R.; Camci C.; Sevinc A.; Demirbilek O.; Ertas E.; Buyukberber S.[No abstract available]Öğe The effects of abdominal and bimanual pelvic examination and transvaginal ultrasonography on serum CA-125 levels(2000) Sari R.; Buyukberber S.; Sevinc A.; Ates M.; Balat O.; Hascalik S.; Turk M.The need for the early detection of ovarian cancer continues to be one of the most important issues in women's health care. The three most extensively evaluated screening methods for ovarian cancer are pelvic examination, transvaginal ultrasonography, and serum CA-125 levels. The answers to questions such as should the levels of CA-125 be measured before bimanual pelvic examination or transvaginal ultrasonography or do abdominal examinations effect the levels of CA-125 are obscure. Fifty-four otherwise healthy female volunteers at the preovulatory phase of the menstrual cycle complaining of vaginal candidiasis were divided into 3 groups. Abdominal (group 1), bimanual pelvic (group 2), and transvaginal ultrasonography (group 3) examination was performed and serum CA-125 levels were evaluated prior to examination and 10 minutes, 6 hours, and 24 hours after the examination. As a result, serum CA-125 levels (U/ml) were found to be 8.13 ± 4.76, 8.23 ± 5.05, 8.32 ± 4.88, and 8.33 ± 4.94 in the group of abdominal examination, respectively, 8.23 ± 4.89, 8.45 ± 5.15, 8.77 ± 4.96, and 8.79 ± 5.50 in the group of bimanual pelvic examination, respectively, and 8.19 ± 4.56, 8.30 ± 5.10, 8.81 ± 5.56, and 8.88 ± 5.71 in the group of transvaginal ultrasonography, respectively. The serum CA-125 levels detected prior to examinations were statistically insignificant when compared with the results obtained at 10 minutes, 6 hours, and 24 hours later in all three groups. We concluded that physical examination, either abdominal or pelvic, and transvaginal ultrasonography do not change the serum levels of CA-125.Öğe Gluten-free Diet Improves Iron-deficiency Anaemia in Patients with Coeliac Disease(2000) Sari R.; Yildirim B.; Sevinc A.; Buyukberber S.Two cases of newly-diagnosed asymptomatic coeliac disease with 3 years of unexplained severe iron-deficiency anaemia are presented. Oral iron supplementation had no effect on their serum iron levels and, therefore, had no influence on their anaemia. Upper gastrointestinal endoscopy confirmed normal macroscopic findings. Duodenal biopsies revealed subtotal villous atrophy of the mucosa of the small intestine. A strict gluten-free diet led to an increase in serum iron, resolution of anaemia, and restitution of normal mucosal morphology. Thus, severe iron-deficiency anaemia associated with asymptomatic coeliac disease is responsible to gluten-free diet.Öğe Idiopathic hypoparathyroidism and celiac disease in two patients with previous history of cataract.(2000) Sari R.; Yildirim B.; Sevinc A.; Buyukberber S.We report two patients with idiopathic hypoparathyroidism and celiac disease. Both had undergone surgery for cataract previously. The patients presented with tetany in the absence of gastrointestinal complaints. Investigations showed severe hypocalcemia, hypoparathyroidism, flattening of duodenal villi histologically, and diffuse cerebral and basal ganglia calcifications on CT scan. After a gluten-free diet with calcium supplementation, the clinical situation and biochemical values improved.Öğe Mechanisms of immune dysfunction in stem cell transplantation(2000) Talmadge J.E.; Singh R.; Ino K.; Ageitos A.; Buyukberber S.High dose therapy (HDT) and stem cell transplantation (SCT) results in alterations in the immunologic network, thymic re-education and the induction of peripheral tolerance. The changes to the immunoregulatory cascade and tolerance induction associated with autotransplants have been investigated in a series of studies focused on leukocyte reconstitution and function following HDT and autologous SCT. In these studies, we observed a significant decrease in the CD4:CD8 T cell ratio post-transplantation compared to normal peripheral blood (PB) donors due to a decrease in CD4+ cells. In addition, T cell function (phytohemagglutinin (PHA) mitogenesis) was consistently depressed compared to samples obtained from normal PB donors. The loss of T cell function was associated with an increased frequency of circulating monocytes, their expression of Fas ligand (FasL) and a high frequency of apoptotic CD4+ T cells. Indeed, 28-51% of circulating CD4+ T cells were observed to be apoptotic during the first 100 days following HDT and SCT. These studies suggest that 'primed' or activated Fas+ CD4+ lymphocytes interact with FasL+ monocytes, resulting in apoptosis, leading to the preferential deletion of CD4+ T cells, a decrease in the CD4:CD8 T cell ratio and depressed T cell function. Further, as discussed herein, the T cells are activated with a predominantly type 2 phenotype, which may also contribute to the maintenance of the immunosuppressive condition. Therefore, there is the potential to regulate immune recovery by stem cell product manipulation or post-transplantation cytokine administration. © 2000 International Society for Immunopharmacology.Öğe A secondary interpretation is needed on serum CA 125 levels in case of serosal involvement (multiple letters)(2000) Sevinc A.; Sari R.; Carnei C.; Buyukberber S.; Ahmed A.S.M.; Long M.; Donaldson D.[No abstract available]Öğe Synchronous primary malignant neoplasms of colon and bladder.(2001) Sari R.; Buyukberber S.; Sevinc A.; Mizrak B.Extracolonic and synchronous malignancies are rare in colorectal carcinomas. We report a 68-year-old man with complaints of rectal bleeding and hematuria. Endoscopic biopsies revealed synchronous adenocarcinoma of the colon and transitional cell carcinoma of the bladder. The patient was started on chemotherapy, and is alive (with disease) nine months later.
