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    BRAIN-STEM AUDITORY-EVOKED POTENTIALS AND BLINK REFLEXES IN PATIENTS WITH PONTOCEREBELLAR ANGLE TUMORS
    (Walter De Gruyter & Co, 1994) NURLU, G; BAVBEK, M; COLAK, A; SARJBAS, O; OZGEN, T
    Brainstem auditory evoked potentials (BAEP) and blink reflexes (BR) were obtained from 13 patients with pontocerebellar angle (PCA) tumors whose pathological diagnosis was as follows: 7 acoustic neurinoma, 3 meningioma, 1 neurinoma, 1 brain stem epidermoid tumor, 1 arteriovenous malformation. The most prominent abnormality was noted in BAEP generated by stimulating the ear ipsilateral to the lesion and ipsilateral R(1) reflexes obtained from ipsilateral stimulation of the supraorbital nerve.
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    EFFICACY OF HIGH-DOSE AMINO-ACID SOLUTION ON SPINAL-CORD INJURY-INDUCED BY FOCAL ND-YAG LASER IRRADIATION
    (Springer Wien, 1995) COLAK, A; NURLU, G; ACIKGOZ, B; OZCAN, OE
    In this experimental study, a neodymium: yttrium-aluminium-garnet (Nd:YAG) laser was used to induce highly reproducible focal spinal cord lesions in anaesthetized guinea pigs. The efficacy of high dose amino acid solution (HDAAS) on this injury is investigated. Experiments were performed on 36 animals divided into three groups; sham operated controls, laser irradiated surgical controls, and amino acid groups. Acute responses to injury were evaluated with somatosensory (SSEP) and motor evoked potentials (MEP) and functional recovery was assessed for 8 weeks using the inclined plane technique. In the laser irradiated surgical control group, MEP disappeared one hour after the laser injury, but SSEP revealed changes of amplitude and latency. In this group, the average value of the inclined plane at 24 hours after the laser application was 45.3 +/- 1.4 degrees. In the amino acid group, at the sixth hour of injury, MEP and SSEP changes improved with infusion of HDAAS for 4 hours. This improvement was statistically significant (for latency of SSEP U = 140 p < 0.05). Inclined plane value at 24 hours after the laser application was 65.5 +/- 1.2 degrees in this group. This study showed that application of Nd:YAG laser irradiation on the spinal cord induced spinal cord injury which presented as paraparesis, HDAAS may provide significant therapeutic protection in secondary damage following this injury and may have a potential role in the treatment of acute spinal cord injury.
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    REACTION OF RABBIT LATERAL PERIVENTRICULAR TISSUE TO NONINFECTED AND INFECTED (STAPHYLOCOCCUS-EPIDERMIDIS) SHUNT TUBING IMPLANTS - A LIGHT AND TRANSMISSION ELECTRON-MICROSCOPE STUDY
    (Springer-Verlag Wien, 1993) GEDIKOGLU, Y; COLAK, A; BENLI, K; ERBENGI, T
    The reactions of periventricular tissue of the lateral ventricle to non-infected and infected (Staphylococcus Epidermidis) silicone shunt tubing were examined by light and transmission electron microscopy. It was shown that reactive changes occurred in periventricular tissue in response to the implant of sterile shunt tubing. On the other hand in infected implanted silicone shunt tubing, proliferation of inflammatory cells within the ventricle and periventricular tissue, loss of integrity of the ependyma, glial cell proliferation, and excessive extracellular oedema were demonstrated. Proliferation of ependymal cells combined with inflammatory responses may be a factor in the pathogenesis of infected shunt obstruction.