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Öğe The Acute Effect of Humic Acid on Iron Accumulation in Rats(Humana Press Inc, 2016) Cagin, Yasir Furkan; Sahin, N.; Polat, A.; Erdogan, M. A.; Atayan, Y.; Eyol, E.; Bilgic, Y.Free iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and the histopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.Öğe Albendazole Induced Recurrent Acute Toxic Hepatitis: A Case Report(Univ Catholique Louvain-Ucl, 2017) Bilgic, Yilmaz; Yilmaz, Cengiz; Cagin, Yasir Furkan; Atayan, Yahya; Karadag, Nese; Harputluoglu, Murat Muhsin MuhipIntroduction : Drug induced acute toxic hepatitis can be idiosyncratic. Albendazole, a widely used broad spectrum antiparasitic drug is generally accepted as a safe drug. It may cause asymptomatic transient liver enzyme abnormalities but acute toxic hepatitis is very rare. Case Report : Herein, we present the case of 47 year old woman with recurrent acute toxic hepatitis after a single intake of albendazole in 2010 and 2014. The patient was presented with symptoms and findings of anorexia, vomiting and jaundice. For diagnosis, other acute hepatitis etiologies were excluded. Roussel Uclaf Causality Assessment Method (RUCAM) score was calculated and found to be 10, which meant highly probable drug hepatotoxicity. Within 2 months, all pathological findings came to normal. Result : There are a few reported cases of albendazole induced toxic hepatitis, but at adults, there is no known recurrent acute toxic hepatitis due to albendazole at this certainty according to RUCAM score. Conclusion : Physicians should be aware of this rare and potentially fatal adverse effect of albendazole.Öğe Ascites and hepatic involvement: a rare and atypical presentation of Burkitt Lymphoma(Turgut Özal Tıp Merkezi Dergisi, 2016) Seçkin, Yüksel; Cagin, Yasir Furkan; Özkan, Ahmet Selim; Bilgiç, Yılmaz; Yıldırım, Oğuzhan; Erdoğan, Mehmet Ali; Atayan, Yahya; Kırımlıoğlu, Hale; Aydoğdu, İsmetAbstract Burkitt lymphoma (BL) is an uncommon form of lymphoma in adults. In this disease, extensive involvement of the omentum and the peritoneum is rare. We present this case with ascites because it is such a rare and overlooked clinical presentation of BL. A previously healthy 20-year-old man was admitted to our hospital with abdominal pain, distension, and night sweats. Physical examination revealed massive ascites. Computerized tomography showed liver metastasis and ascites, but no pathologic thoracal or abdominal lympadenopathy was reported. Atypical lymphocytic cells with cytoplasmic vacuoles were determined on cytologic examination of ascites. We detected starry sky view on the bone marrow examination. On immunophenotyping, cells were CD20 positive, but negative for CD30, CD79a/Tdt. Patient was diagnosed as BL. Burkitt lymphoma should be considered in young patients presenting with ascites and hepatic mass even without lymphadenopathy or focal gastrointestinal masses. Keywords: Ascite; Hepatic İnvolvement; Burkitt Lymphoma.Öğe Ascites and hepatic involvement: a rare and atypical presentation of Burkitt Lymphoma(Turgut Özal Tıp Merkezi Dergisi, 2016) Seçkin, Yüksel; Cagin, Yasir Furkan; Özkan, Melda Çömert; Bilgiç, Yılmaz; Yıldırım, Oğuzhan; Erdoğan, Mehmet Ali; Atayan, Yahya; Kırımlıoğlu, Hale; Aydoğdu, İsmetAbstract Burkitt lymphoma (BL) is an uncommon form of lymphoma in adults. In this disease, extensive involvement of the omentum and the peritoneum is rare. We present this case with ascites because it is such a rare and overlooked clinical presentation of BL. A previously healthy 20-year-old man was admitted to our hospital with abdominal pain, distension, and night sweats. Physical examination revealed massive ascites. Computerized tomography showed liver metastasis and ascites, but no pathologic thoracal or abdominal lympadenopathy was reported. Atypical lymphocytic cells with cytoplasmic vacuoles were determined on cytologic examination of ascites. We detected starry sky view on the bone marrow examination. On immunophenotyping, cells were CD20 positive, but negative for CD30, CD79a/Tdt. Patient was diagnosed as BL. Burkitt lymphoma should be considered in young patients presenting with ascites and hepatic mass even without lymphadenopathy or focal gastrointestinal masses. Keywords: Ascite; Hepatic İnvolvement; Burkitt Lymphoma.Öğe Assessment of the endoscopy and colonoscopy results inrelation with the age groups in the patients suffering anemia(2022) Bilgiç, Mehmet Akif; Cagin, Yasir FurkanAim: The aim is to investigate the importance of gastrointestinal system lesions in the etiology of anemia according to the results of gastroscopy and colonoscopy in patients with anemia according to age groups. With this, it is to determine the predictive factors that will provide or stimulate early diagnosis, especially in malignant diseases. Material and Methods: In this study, the patients undergoing gastroscopy and colonoscopy with the diagnosis of anemia between 01 January 2013 and 01 January 2019 were evaluated retrospectively. 189 patients over 18 (93 female, 96 male) were covered. The patients were divided into two groups, namely below 65 and over 65. The final diagnosis was made according to outcomes of endoscopic biopsy. Results: The gastroscopy (n=189) showed a benign appearance in 173 patients (91.5%), a malign appearance in 9 (4.8%) and bleeding lesions in 7 (3.7%). In the colonoscopic evaluation (n=189), 132 patients (69.8%) were normal, 26 (13.8%) benign, 21 (11.1%) malign, in 10 (5.3%) of the patients no focus was detected due to bleeding. Malignant patients were evaluated according to age and gender, 4 (2.1%) women and 11 (5.8%) men were detected in the group under 65 years of age, and 5 women (2.6%) and 10 men (5.3%) in the patient group over 65 years of age. Colorectal cancer was detected in 20 (10.6%) of total 21 (11.1%) malignant patients, making it the most frequent malignant disease. Conclusion: Gastroscopy and colonoscopy in the patients with anemia is very important with regard to establishment of etiology. The advanced age patients with anemia must be scanned for malign disorders.Öğe Association of CagA-positive Helicobacter pylori infection with severity of obstructive sleep apnea syndrome(Scientific Publishers India, 2016) Yildirim, Oguzhan; Bali, Ilhan; Tulubas, Feti; Mete, Rafet; Topcu, Birol; Seckin, Yuksel; Cagin, Yasir FurkanAim: To investigate the association between Helicobacter pylori cytotoxin-associated gene-A (CagA) status and the severity of OSA syndrome in infected patients. Methods: Ninty-six patients with obstructive sleep apnea syndrome (OSAS) and 30 age-and sex-matched control subjects with no history of OSA or gastrointestinal complaints were included in the study. Patients' apnea-hypopnea index (AHI) was determined by polysomnography (PSG), and serum H. Pylori IgG and cytotoxin-associated gene-A IgG was assayed by enzyme-linked immunosorbent assay (ELISA). Based on their AHI score, subjects were assigned to one of three groups: a control group (AHI<5), a mild-moderate OSAS group (AHI >= 5 and < 30), and a severe OSAS group (AHI >= 30). Results: The prevalence of H. pylori IgG seropositivity was significantly higher in the severe OSAS group compared to the mild-moderate OSAS group [ 29 (90.6%) patients versus 41 (64%) patients, (p=0.007)]. In addition, CagA seropositivity was present in 10 control patients (58.8%), 23 mild-moderate OSAS patients (56%), and 25 severe OSAS patients (86.2%). There was a significantly higher prevalence of CagA seropositivity in the severe OSAS group compared to mild-moderate OSAS group (p=0.027). There was no significant difference in CagA seropositivity between the mild-moderate OSAS group and the control group (p=0.059). Conclusion: Our findings suggest that H. pylori strains expressing CagA may be considered a risk factor in the severity of OSAS.Öğe Association of eNOS Gene Polymorphisms G894T and T-786C with Risk of Hepatorenal Syndrome(Hindawi Ltd, 2016) Seckin, Yuksel; Yigit, Ali; Yesilada, Elif; Gulbay, Gonca; Cagin, Yasir Furkan; Gozukara, Harika; Bilgic, YilmazBackground. There are no studies investigating the relationship between endothelial nitric oxide synthase (eNOS) gene polymorphisms and hepatorenal syndrome (HRS). Aim. The purpose of this study is to elucidate whether eNOS gene polymorphisms (G894T and T-786C) play a role in the development of type-2 HRS. Methods. This study was carried out in a group of 92 patients with cirrhosis (44 patients with type-2 HRS and 48 without HRS) and 50 healthy controls. Polymorphisms were determined by polymerase chain reaction (PCR) and melting curve analysis. Results. We did not find any significant difference in allele and genotype distributions of the eNOS -T-786C polymorphism among the groups (p = 0.440). However, the frequency of GT (40.9%) and TT (13.6%) genotypes and mutant allele T (34.1%) for the eNOS G894T polymorphism were significantly higher (p < 0.001 and p < 0.001, resp.) in the HRS group than in both the stable cirrhosis (14.6%, 4.2%, and 11.5%, resp.) and the control (22.0%, 2.0%, and 13.0%, resp.) groups. Conclusion. The occurrence of mutant genotypes (GT/TT) and mutant allele T in eNOS -G894T polymorphisms should be considered as a potential risk factor in cirrhotic patients with HRS.Öğe Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model(Taylor & Francis Ltd, 2016) Cagin, Yasir Furkan; Atayan, Yahya; Sahin, Nurhan; Parlakpinar, Hakan; Polat, Alaadin; Vardi, Nigar; Tagluk, Mehmet EminBackground and aim It has been reported that intestinal ischemia-reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury. Materials and methods Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n=8) and alone Dxp (n=8; 500mg/kg, i.m. of Dxp was given at least 30min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity. Results In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group. Conclusions Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.Öğe Comparison of patients with fulminant versus near-miss fulminant drug-induced hepatitis(Allied Acad, 2017) Bilgic, Yilmaz; Akbulut, Sami; Kutlu, Orkide; Yilmaz, Cengiz; Colak, Cemil; Deviren, Mehmet Veysi; Cagin, Yasir FurkanThis study aimed to investigate and compare clinical and laboratory properties of patients with fulminant versus near-miss fulminant drug-induced hepatitis and the effect of these properties on mortality. Drug-induced hepatitis is the most common cause of acute liver failure in western countries. In severe drug-induced hepatitis, once encephalopathy develops, prognosis is poor without liver transplantation. Therefore, it is important to predict prognosis and know the clinical differences between patients developing encephalopathy and patients without encephalopathy. Patients with severe drug-induced hepatitis were researched retrospectively. The identified patients were divided into two groups: with encephalopathy (fulminant hepatitis; 25 patients) and without encephalopathy (near-miss fulminant hepatitis; 48 patients). The clinical properties and biochemical results of the two groups were compared, and parameters that could have an effect on mortality were evaluated. Hemoglobin, platelet count, albumin, and fibrinogen levels were found to be decreased, whereas, International Normalized Ratio (INR), total bilirubin, AST, LDH, lactate, and ammonia levels were found to be increased significantly in the fulminant hepatitis group. Creatinine, Model for End-Stage Liver Disease (MELD) score, and platelet count were found to be independent risk factors on mortality. The development of hepatic encephalopathy negatively impacts patient survival. Therefore, the prediction of a progression to fulminant hepatitis before hepatic encephalopathy develops and the clinical follow-up of patients accordingly are important issues. This study can provide significant insight into patients with severe drug-induced hepatitis.Öğe Could platelet indices be prognostic biomarkers for mild or severe acute pancreatitis?(E-Century Publishing Corp, 2016) Bilgic, Yilmaz; Akbulut, Sami; Kutlu, Orkide; Colak, Cemil; Yilmaz, Cengiz; Seckin, Yuksel; Cagin, Yasir FurkanThe aim of this study was to show the relation of platelet indices with the severity of acute pancreatitis (AP) and if they have any correlation with the severity of AP. Forty-seven patients with AP hospitalized in Department of Gastroenterology, Inonu University Faculty of Medicine were divided into two groups, namely, the severe AP group (n=15) and the mild AP group (n=32). The scores of these patients at days 0, 3 and at the beginning of remission according to the prognostic scoring systems (Ranson, APACHE II, and BISAP criteria), CRP, sedimentation and platelet indices (platelet count, MPV, PDW and PCT) were noted. Mann-Whitney U test was used to compare the groups. Spearman's Rho test was used to evaluate the correlations between the platelet indices and other prognostic factors. Significant differences were found between the groups as regards platelets (P<0.02), PDW (P<0.001), AST (P<0.001), ALT (P<0.001), Total bilirubin (P<0.007), LDH (P<0.001), CRP (P<0.001), sedimentation (P<0.001), APACHE-II (P<0.001), Ranson (P<0.002) parameters. When considered for the correlation between the platelet indices and other prognostic factors, it was seen that all the platelet indices showed strong positive or negative correlation in mild AP with other prognostic scoring systems, CRP and sedimentation. In contrast, it was seen that platelet indices in severe AP cases did not show strong correlation with other prognostic scoring systems, CRP and sedimentation. We showed that platelet derivatives can be used as a good prognostic biomarker for the course of mild AP. In severe AP cases, however, usability of platelet indices must be supported with further studies.Öğe The Course of Endoscopic Treatment Success in Biliary Complications After Living Donor Liver Transplantation(Galenos Publ House, 2024) Ataman, Engin; Harputluoglu, Murat; Bilgic, Yilmaz; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Kutlu, Ramazan; Kutluturk, KorayObjective: Our aim was to present the results of endoscopic retrograde cholangiopancreatography (ERCP) after living donor liver transplantation (LDLT) between February 2015 and June 2021. Methods: Clinical data included LDLT indications, time to perform ERCP after LDLT, number of ERCP procedures, indications for ERCP, and all treatment outcomes, including ERCP, percutaneous, and surgical interventions. We compared the obtained data with our previous study published by our team in 2018, which included 446 patients who underwent ERCP for biliary complications after LDLT between 2005 and 2015. Results: We performed ERCP in 283 of 1506 patients with LDLT who underwent duct-to-duct anastomosis during transplantation and then developed biliary complications. Our endoscopic success rates were 60.9% and 71.0% in the previous and present studies, respectively. Conclusions: Our findings suggest that the success rate of endoscopic treatment of biliary complications in patients with LDLT increases in correlation with the increasing experience of clinicians treating these patients.Öğe Does the tumor necrosis factor a predictor factor in patients with chronic hepatitis B and C(Allied Acad, 2017) Bilgic, Yilmaz; Seckin, Yuksel; Cagin, Yasir Furkan; Yildirim, Oguzhan; Yilmaz, Cengiz; Harputluoglu, Murat; Harputluoglu, HakanAim: In our research, we aimed to investigate the importance and pattern of Tumor Necrosis Factor (TNF) alpha in response to the combinatorial treatment of lamuvidin (LAM) and Pegile interferon (PEG INF) 2a + Ribavirin (RIB) in patients with Chronic Hepatitis B (CHB) and Chronic Hepatitis C (CHC). Material and method: Thirty four CHB and 25 CHC patient samples were taken before and after the treatment and stored appropriately. CHB patients were treated with LAM and CHC patients were treated with using the combination of PEG INF 2a and RIB. HBV DNA, anti HBe, ALT, AST and TNF alpha results were obtained from CHB patients before and 48th week of the treatment. HCV RNA, ALT, AST and TNF alpha results were also obtained from CHC patients before and in the 6th month of completing the treatment. Responses to the treatment were taken as negative result of HBV DNA in CHB patients after finishing the treatment and as negative result of HCV RNA in CHC patients after 6 months of finishing the 48 weeks of PEG INF treatment. Results: At the level of decreasing TNF-alpha in CHB patients when the group responding to the treatment compared to the group not responding to the treatment, a significant difference was observed in favor of the respondent group (p< 0.0001). At the level of decreasing TNF-alpha in CHC patients when the group responding to the treatment compared to the group not responding to the treatment, a significant difference was also obtained in favor of the respondent group (p< 0.0001). In the analysis for emphasizing the importance of TNF alpha level in response to the treatment in CHB patients, it was found that predicting the response to the treatment of TNF alpha was 78.6% sensitivity and 75% specificity for 68.78 cutoff. In the analysis for emphasizing the importance of TNF alpha level in response to the treatment in CHC patients, it was found that determining the response of TNF alpha to the treatment was 100% sensitivity and 100% specificity for 122.4 cutoff. Conclusions: With the treatment a decrease in TNF alpha is occured in CHB and CHC patients; however, TNF alpha decrease in the groups responding to the treatment is more significant. The results of this research show that TNF alpha level may be an important non-invasive marker for foresight and determining the response to the treatment.Öğe Drug induced autoimmune hepatitis: a single center experience.(Allied Acad, 2017) Bilgic, Yilmaz; Harputluoglu, Hakan; Yilmaz, Cengiz; Karadag, Nese; Cagin, Yasir Furkan; Akbulut, Sami; Seckin, YukselObjective: Many drugs such as minocycline, nitrofurantoin, halothane, non-steroidal anti-inflammatory drugs, anti TNF (Tumor Necrosis Factor) antagonists can induce the autoimmune hepatitis. Herein, we aimed to assess patients suffering from drug induced autoimmune hepatitis who were hospitalized with acute hepatitis like transaminase elevations to our clinic between 2009-2015. Method: The patients were determined using simplified diagnostic criteria of the International Autoimmune Hepatitis Group. Results: We determined 9 patients whose score were compatible with the diagnosis of Autoimmune hepatitis (AIH). Three patients were older than 50, and six patients were between 19 and 31. Seven of nine patients were female. The drugs thought responsible for AIH were as follows; ciprofloxacin alone, amoxicillin plus nimesulid, amoxicillin plus ornidazole, amoxicillin alone, a combined oral contraceptive pill plus a mixture of natural drugs, metronidazole plus dexketoprofen, ramipril plus metronidazole, levofloxacin alone and venlafaxine plus mianserin for each case. Five of nine patients had been followed up conservatively upon discontinuation of drug(s) and did not need any treatment during hospitalization and resolved spontaneously. Four patients received immunosuppressive treatment which was withdrawn in 3 of those 4 patients after 3 to 6 months upon remission without relapse. Conclusion: Drug induced autoimmune hepatitis (DIAIH) can be presented with acute hepatitis of unknown etiology. Female sex seems to be a risk factor for DIAH. Treatment decisions should be given according to patient's clinical status and follow up at acute presentations. There can be no treatment need, but, when needed generally a short course of immunosuppressive treatment can be sufficient.Öğe Early therapeutic plasma exchange may improve treatment outcomes in severe acute toxic Hepatitis(Pergamon-Elsevier Science Ltd, 2021) Berber, Ilhami; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Ataman, Engin; Gozukara, Harika; Erkurt, Mehmet Ali; Yildirim, OguzhanBackground and objectives: Acute toxic hepatitis can result in a different clinical course from a completely curable disease to subacute hepatitis, chronic hepatitis, and fulminant hepatitis failure, which is quite mortal. For this purpose, therapeutic plasma exchange (TPE) can be used for improving treatment outcomes by reducing the harmful substances caused with and/or without liver function in acute toxic hepatitis. We aimed to evaluate treatment outcomes in severe acute toxic hepatitis patients who applied early TPE procedure. Materials and Methods: A total of 335 patients who received TPE between 2010-2021 were retrospectively screened and 59 (male/female, 30/29; min/max-age, 22-84) patients with acute toxic hepatitis who underwent TPE in the first 24 h were included in the study. TPE was performed in patients who had high total bilirubin level (>10 mg/dL). Laboratory parameters of the patients before and after the TPE procedure, number of patients developed complications of acute toxic hepatitis and mortality rates were evaluated for effectiveness of TPE. Results: Acute toxic hepatitis was associated with hepatotoxic drugs in 44 (74.5 %), herbal medication 6 (10.2 %), mushroom poisoning 6 (10.2 %) and with substance abuse 3 (5.1 %) in patients. When the patients were compared based on INR, liver function tests, ammonia, lactate and Model For End-Stage Liver Disease (MELD) score at baseline, 48 h after TPE (independently of TPE number) and before final state a statistically significant decrease was observed in all parameters (p < 0.05). Fifty three (90 %) of patients improved without complications, the remaining 6 (10 %) patients were diagnosed with fulminant hepatitis. All these remaining patients died before liver transplantation (LTx) could be performed. Conclusion: TPE is a safe, tolerable therapy option and early TPE may improve treatment outcomes in severe acute toxic hepatitis.Öğe Early treatment with esophageal stenting in trauma-induced esophageal perforation- a case report and literature review(2019) Cagin, Yasir FurkanAbstract: Esophageal perforation is a life-threatening clinical condition that was usually treated with surgical intervention in the past. There is no definite consensus on the ideal treatment that is controversial. Early diagnosis and treatment are very important. So, this condition improves treatment success. Nowadays, with the use of clips and selfexpandable removable stents, it becomes an entity that facilitates conservative treatment. Here, we present 37-year-old male patient who was admitted to the emergency department after being assaulted with a knife in his right upper chest. He Healed in a short time after esophageal stent placement in early esophageal perforation.Öğe Ecstasy induced acute hepatic failure. Case reports(Univ Catholique Louvain-Ucl, 2015) Atayan, Yahya; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Harputluoglu, Muhsin Murat Muhip; Bilgic, Yilmaz3,4-methylenedioxymethamphetamine (MDMA), an amphetamine derivative known as ecstasy, has stimulating and hallucinogenic properties. It has become a substance that is widely used especially by young people. Hepatotoxicity is one of the rare side effects of this substance and can be fatal. Ecstasy-induced fulminant hepatitis has been reported in case reports. The clinical course and the prognosis of the cases may differ. In this article, two cases in whom ecstasy-induced fulminant hepatic failure had developed and who were treated with liver transplantation, and one case which recovered with treatment, have been presented.Öğe Effectiveness of human albumin solution in the treatment of patients with cirrhosis(2022) Cengiz, Ayse Nuransoy; Cagin, Yasir Furkan; Seckin, Yuksel; Karıncaoğlu, MelihAbstract Aim: Human serum albumin is synthesized in the liver and is the main plasma protein responsible for plasma oncotic pressure. Studies on the use of Human albumin solution (HAS) in patients with cirrhosis, for prevention of cirrhosis complications or for treatment are ongoing. The beneficial role of albumin beyond volume expansion is an evolving topic, and further research is needed to understand its role in modulating biological functions and disease processes, particularly in liver disease and sepsis, but also in other diseases that involve albumin dysfunction. Materials and Methods: We investigated the effectiveness of HAS through the patients with cirrhosis who received 3 consecutive days (2x1 per day) 190-210 g / L protein were retrospectively analyzed. Results: Albumin infusion was found to be beneficial for serum albumin levels in the patient with high Child-Pugh scores. Conclusion: The complications of cirrhosis can be reduced, particularly in patients awaiting transplantation, by support with HAS treatment.Öğe Effects of dexpanthenol on acetic acid-induced colitis in rats(Spandidos Publ Ltd, 2016) Cagin, Yasir Furkan; Parlakpinar, Hakan; Vardi, Nigar; Polat, Alaadin; Atayan, Yahya; Erdogan, Mehmet Ali; Tanbek, KevserWhile the pathogenesis of acetic acid (AA)-induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim of the present study was to elucidate the therapeutic potential of dexpanthenol (Dxp) on the amelioration of colitis in rats. Group I (n=8; control group) was intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] was administered 4% AA into the colon via the rectum as a single dose for three consecutive days; group III (n=8; AA + Dxp) was administered AA at the same dosage as group II from day 4, and a single dose of Dxp was administered intraperitoneally; and group IV (n=8; Dxp) was administered Dxp similarly to Group III. Oxidative stress and colonic damage were assessed via biochemical and histologic examination methods. AA treatment led to an increase in oxidative parameters and a decrease in antioxidant systems. Histopathological examination showed that AA treatment caused tissue injury and increased caspase-3 activity in the distal colon and triggered apoptosis. Dxp treatment caused biochemical and histopathological improvements, indicating that Dxp may have an anti-oxidant effect in colitis; therefore, Dxp may be a potential therapeutic agent for the amelioration of IBD.Öğe Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial(Mdpi, 2024) Dogan, Ozge Erol; Celik, Kezban Esen Karaca; Bas, Murat; Alan, Eyup Hakan; Cagin, Yasir FurkanThis study aimed to investigate the effects of the Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis (UC). This study was designed as a prospective multicenter three-arm randomized controlled trial. Participants were randomized to the MD, MD + curcumin, and MD + resveratrol groups. All participants were placed on the MD for 8 weeks. The MD + curcumin group also received 1600 mg/day of curcumin supplementation, whereas the MD + resveratrol group received 500 mg/day of resveratrol supplementation for 8 weeks. Anthropometric measurements, Truelove-Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Mediterranean Diet Adherence Scale (MEDAS), and laboratory tests were performed at baseline and postintervention. Within-group comparisons showed that MD, MD + curcumin, and MD + resveratrol interventions were effective in reducing disease activity and inflammation and improving quality of life in individuals with UC (p < 0.05). Between-group comparisons revealed no significant difference in all parameters except for the pain subparameter of SF-36 and the MEDAS score (p < 0.05). The MD is an effective and safe intervention to be used in clinical practice in individuals with UC.Öğe EFFECTS OF RENAL REPLACEMENT THERAPY ON FIBROMYALGIA SYNDROME IN PATIENTS WITH CHRONIC KIDNEY DISEASE(Carbone Editore, 2018) Berber, Ilhami; Sahin, Idris; Gorgel, Ahmet; Cagin, Yasir Furkan; Bag, Harika Gozukara; Berber, Nurcan KiriciIntroduction: Although musculoskeletal disorders are among the major complications of chronic kidney disease (CKD), there are scarce data to investigate fibromyalgia syndrome (FMS) in these patients. We aimed to investigate the prevalence of FMS in the patients with CKD. Material and methods: A total of 289 (119 predialysis (PD), 85 hemodialysis (HD), 85 continuous ambulatory peritoneal dialysis (CAPD)) patients were included. Diagnosis of FMS was based on American College of Rheumatology (ACR) 1990 FMS criteria. Results: Mean age was 52 +/- 16 years (range 18-89 years). One-hundred-sixty-four (56.7%) of them were male. A total of 46 patients (10 male/36 female) (15.9%) were diagnosed FMS. The prevalence of FMS was 28.8% in females and 6.1% in males. Compared to males, females had a significantly higher rate of FMS (p<0.001). The prevalence of FMS was 19.3% in PD group, 17.6% in the CAPD group, and 9.4% in the HD group. Although the frequency of FMS was lower in HD group compared to both the PD and the CAPD groups, the differences were not statistically significant (for HD vs PD, p=0.052; for HD vs CAPD, p=0.113). In PD group, hemoglobin (Hb) levels were significantly higher in patients with FMS than without FMS. Parathormone (PTH) levels were significantly lower in CAPD patients with FMS than without FMS. Although the prevalence of FMS was increased in PD and CAPD patients, this increase did not reach statistical significance. FMS was markedly more prevalent in female patients. While the Hb level was lower in the PD patients with FMS, PTH level was lower in the CAPD patients diagnosed with FMS. Conclusions: Our study demonstrated that the rate of FMS was higher in PD and CAPD patients compared to HD patients, although our results did not reach statistical significance. Among the entire demographic and laboratory parameters, female gender was found to be significant risk factor for development of FMS. Future multicenter studies which have large sample size are clearly needed to determine other factors related to development of FMS in patients with CKD.