Yazar "Caglayan, Ahmet Burak" seçeneğine göre listele

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    Effects of Central Infusion of Irisin on the Energy Metabolism and Glucose Uptake in Rats
    (Karger, 2018) Erden, Yavuz; Tekin, Suat; Caglayan, Ahmet Burak; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, Cemil; Sandal, Suleyman
    [Abstract Not Available]
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    Effects of Peripheral Irisin Infusion on the Glucose Uptake in High-Fat-Diet-Induced Obese Rats
    (Wiley, 2018) Sandal, Suleyman; Tekin, Suat; Erden, Yavuz; Caglayan, Ahmet Burak; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, Cemil
    [Abstract Not Available]
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    Schiff Base-Poloxamer P85 Combination Prevents Prostate Cancer Progression in C57/Bl6 Mice
    (Wiley, 2016) Dogan, Aysegul; Demirci, Selami; Turkmen, Nese Basak; Caglayan, Ahmet Burak; Aydin, Safa; Telci, Dilek; Kilic, Ertugrul
    BACKGROUNDProstate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, tumors become refractory to established chemotherapeutic treatments and cause serious problems at the clinics. Development of new drug molecules that are able to transport through the membrane easily and kill tumor cells rapidly is of great interest. METHODIn the current study, a novel Heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used for prostate cancer treatment in vivo. Tramp-C1 cells injected animals were subjected to chemotherapeutic formulation treatment and results were analyzed by toxicology analysis, tumor volume measurements, and histopathological analysis. 0.5mg/kg Schiff base was selected and combined with 0.05% P85 according to the toxicology analysis showing the enzyme levels, blood parameters, and multiple organ toxicity. RESULTSResults demonstrated that Heterodinuclear copper(II)Mn(II) complex-P85 combination decreased tumor formation and tumor volume steadily over the course of experiments. CONCLUSIONSOverall, Heterodinuclear copper(II)Mn(II) complex-P85 exerted remarkable anti-cancer activity in vivo in C57/B16 mice. Prostate 76:1454-1463, 2016. (c) 2016 Wiley Periodicals, Inc.