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Öğe The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats(Elsevier, 2020) Cakir, Murat; Tekin, Suat; Okan, Asli; Cakan, Pinar; Doganyigit, ZuleyhaUncontrolled infection and increased inflammatory mediators might cause systemic inflammatory response. It is already known that Cannabinoid Type 2 (CB2) receptors, which are commonly expressed in immune cells and in many other tissues, have an effect on the regulation of immune response. In the present study of ours, the effects of CB2 receptor agonist JWH-133 was investigated on cecal ligation and puncture (CLP)-induced polymicrobial sepsis model in rats. In the present study, Sprague-Dawley rats were divided into 5 groups (i.e. the Sham, CLP, JWH-133 0.2 mg/kg, JWH-133 1 mg/kg, and JWH-133 5 mg/kg Groups). Except for the Sham Group, the CLP-induced sepsis model was applied to all groups. The histopathological damage in brain, lung, liver and, heart was examined and the caspase-3, p-NF-kappa B, TNF-alpha, IL-1 beta and IL-6 levels were determined immunohistochemically. The serum TNF-alpha, IL-1 beta, IL-6, IL-10 levels were examined with the ELISA Method. The JWH-133 treatment decreased the histopathological damage in brain, heart, lung, and liver and reduced the caspase-3, p-NF-kappa B, TNF alpha, IL-1 beta, IL-6 levels in these tissues. In addition to this, JWH-133 treatment also decreased the serum TNF-alpha, IL-1 beta, IL-6 levels, which were increased due to CLP, and increased the anti-inflammatory cytokine IL-10 levels. In the present study, it was determined that the CB2 receptor agonist JWH-133 decreases the CLP-induced inflammation, and reduces the damage in brain, lung, liver and heart. Our findings show the therapeutic potential of the activation of CB2 receptors with JWH-133 in sepsis.Öğe Attention Performance is not Decreased in the Health Professionals Throughout Their Night-shifts(Wiley, 2017) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Autonomic nervous system activity under rotational shift programs: effects of shift period and gender(Natl Inst Occupational Safety & Health, Japan, 2022) Cakan, Pinar; Yildiz, SedatRotational shifts perturb homeostatic mechanisms in a sexually dimorphic way and may compromise the activity of the autonomic nervous system during day-and night-shifts. Heart rate variability (HRV) is a non-invasive measure to assess autonomic control of the heart. Our aim in this study was to assess HRV by short-term continuous electrocardiogram in female (n=40, average age: 31, average working year: 7) and male (n=40, average age: 29, average working year: 6) nurses under rotational shift programs, HRV is derived from short-term electrocardiogram recordings, carried out both at day-and night-shifts, and included time-domain [e.g., standard deviation of NN intervals, SDNN (ms); percentage of successive RR intervals that differ by more than 50 ms, pNN50 (%); root mean square of successive RR interval differences, RMSSD (ms)] and frequency-domain [very low frequency, VLF; low frequency, LF; high frequency, HF; LF/HF] parameters. Heart rates were similar across the groups but males had lower SDNN (p=0.020), RMSSD (p=0.001). pNN50 (p=0.001), VLF (p=0.048) and HF (p=0.001) but had higher LF/HF ratio (p=0.000) than females. In general, these parameters did not differ between day-and night-shifts (p>0.05). Lower HRV parameters and higher LF/HF in males suggest that they may be under greater threat for disease progression.Öğe Cardiac autonomic control during platelet apheresis(2022) Cakan, Pinar; Ozgul, Mustafa; Erkut, Mehmet Ali; Kaya, Emin; Yıldız, Sedat; Kuku, İrfanAim: The aim of the current study was to assess the effects of platelet apheresis (PA) on cardiac autonomic control by the means of short-term heart-rate variability (HRV) technique. Materials and Methods: A total of 100 platelet donors (age: 29.0±0.9 years, body mass index: 25.8±0.7) were evaluated for heart rate (HR), HRV and blood pressure through a full cycle of PA. HR and HRV were assessed by 5-min continuous electrocardiographic recordings at four occasions, i.e., 5 min before (-5 min), and at 10th min (10 min), 45th min (45 min) and at post 5th min of PA. Time- and frequency-domain parameters of HRV were calculated using specific software. Low-frequency (LF)/high-frequency (HF) ratio was also determined. Blood pressure (BP) was also recorded 5 min before and 5 min after PA. Results: HR increased towards 45th min and declined towards the end of the PA (P < 0.05). Both time- and frequency-domain parameters decreased towards the 45th min and increased towards the last 5th mins (P < 0.05). LF/HF was increased towards 45th min and declined towards the end of the PA. Systolic BP decreased from 111 (106-120) mm Hg to 107 (99-115) mm Hg (P=0.003). Conclusions: HR, HRV and blood pressure were dynamically changed throughout the process of PA. These changes appeared to be caused by increased cardiac sympathovagal balance, resembling the pattern observed during whole blood donation.Öğe Comparison of Effects of Three Distinct Stress Models on Anxiety- and Depression-Related Behaviors in Female Rats(2019) Şahin, Zafer; Koc, Aynur; Ozen Koca, Raviye; Ozkurkculer, Alpaslan; Cakan, Pinar; Gormus Solak, Z. Isik; Kutlu, SelimAbstract: Objective The aim of the present study was to compare the effects of three distinct stress protocols on anxiety/depression-related behaviors in adult female rats.( Sakarya Med J 2019, 9(1): 131-140 )Materialsand MethodsAdult Wistar rats were randomly divided into four groups (n=8/ group) as control, immobilization stress-1 (daily 45 minutes) immobilization stress-2 (daily twice 45minutes) and social isolation (rats were housed in a metabolic cage). Stress protocols were performed for a period of 10 days. When the animals were in diestrus, anxiety anddepression-like behaviors were evaluated by the open field test and forced swimming test, respectively. Anxiety and depression tests were repeated after a 10-day rest period.Results In the open field test, a percentage of time spent in the central area was lower in the immobilization stress-2 and social isolation (p<0.05) groups and total distance was lowerin the immobilization stress-1 (p<0.01) and the social isolation groups (p<0.05). Rearing score was lower in the social isolation group (p<0.05). Swimming behaviors werelower (p<0.01), and immobility durations were higher (p<0.05) in the immobilization stress-1 and social isolation groups. In the second tests, time spent in the central areawas lower in the immobilization stress-1 (p<0.05) and the immobilization stress-2 (p<0.01) groups. Swimming behaviors were lower and immobility behaviors were higherin the immobilization stress-1 group (p<0.001) and the social isolation group (p<0.01 and p<0.001, respectively).Conclusion We suggest that depression-like behaviors are more dominant in the immobilization stress-1 and social isolation groups of adult female rats because the depression-relatedresults of these two groups are valid both after the stress period and after the rest period.Öğe The Comparison of Sympatho-Vagal Tonus According to Gender in Health Personnel Working in Shift System(Wiley, 2019) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Daytime Fasting Appears to be Beneficial as it Increases Heart Rate Variability Towards Evening(Wiley, 2018) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Development and validation of a corticosterone enzyme immunoassay for rat plasma(Wiley-Blackwell, 2016) Cakan, Pinar; Ozgocer, Tuba; Yildiz, Sedat[Abstract Not Available]Öğe Does Maternal Viral Infection At A Critical Window Of Fetal Hypthalamic Nuclei Development Program Puberty And Gonadal Development In Male Rat Offsprings?(Wiley-Blackwell, 2015) Cakan, Pinar; Yildiz, Sedat; Ozgocer, Tuba; Yildiz, Azibe; Vardi, Nigar[Abstract Not Available]Öğe Effects of Fasting in the Month of Ramadan on Circadian Cortisol Levels(Wiley-Blackwell, 2015) Ozgocer, Tuba; Ucar, Cihat; Yildirim, Hilal; Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Effects of Half or Whole Night Shift in Women on Melatonin and Leptin Concentrations(Wiley, 2018) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Effects of Half- or Whole-Night Shifts on Hypothalamo-Pituitary-Adrenal Axis and Autonomic Nervous Systems in Women(Karger, 2021) Cakan, Pinar; Yildiz, Sedat; Barutcu, Ozlem; Ucar, Cihat[Abstract Not Available]Öğe Effects of Half- or Whole-Night Shifts on Physiological and Cognitive Parameters in Women(Elsevier Science Inc, 2020) Cakan, Pinar; Yildiz, SedatBackground: The study assessed the effects of whole- or half-night shifts on leptin, melatonin, sex hormones, interleukin (IL)-1 beta, tumor necrosis factor-alpha (TNF-alpha), IL-6, hematological parameters, sleep quality and attentional performance in women working in the health sector. Materials and Methods: Women working whole-night shifts (16:00-08:00 hours, n = 20), half-night shifts (16:0024:00 hours, n = 20) or day shifts (08:00-16:00 hours, n = 20) participated in the study. Blood pressure, respiratory rate, proximal skin temperature (forehead), blood glucose, leptin, melatonin, estradiol, progesterone, IL-1 beta, TNF-alpha, and IL-6 concentrations, complete blood count and erythrocyte sedimentation rate (ESR) were measured in the beginning and at the end of the shifts. The participants filled in sleep quality questionnaires and performed visual attention tests. Results: Half- and whole-night shifts caused problems in sleep duration and quality and disturbed the melatonin rhythm. Women working both half- and whole-night shifts had significantly higher nucleated erythrocytes (P = 0.006), eosinophils (P = 0.031), lymphocytes (P = 0.001) and leptin concentrations (P = 0.001) but had lower ESR (P = 0.046) and neutrophil percentage (P = 0.001) than that of day-time workers. Whole-night shifts caused additional changes including lower attentional performance (P = 0.035), lower platelet counts (P = 0.000) and lower estradiol levels (P = 0.029), but higher TNF-alpha levels (P = 0.000), than the control group. Moreover, whole-night shifts increased IL-1 beta levels before the shift (P < 0.001) and increased IL-6 levels over the half-night shifts (P < 0.05). Conclusions: Half-night shifts disturbed sleep parameters and the melatonin rhythm, perturbed blood cell turnover and increased leptin levels. Whole-night shifts caused additional problems including suppressed estradiol, activated inflammatory responses and decreased visual attention. All together, the data suggest that night shifts, especially whole-night shifts, should be refrained from or countermeasures should be taken.Öğe Effects of Maternal Viral Mimetic Administration on Reproductive System of Female Rat Offsprings(Wiley-Blackwell, 2015) Cakan, Pinar; Yildiz, Sedat; Yildiz, Azibe; Ozgocer, Tuba; Vardi, Nigar[Abstract Not Available]Öğe Effects of noopept on cognitive functions and pubertal process in rats with diabetes(Pergamon-Elsevier Science Ltd, 2019) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Cakan, Pinar; Kaya, Gul Busra; Bag, Harika Gozde Gozukara; Durhan, MerveAim: Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties. We tried to determine the effects of noopept on pubertal diabetes. Main method: The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats. The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept. T1DM model was induced by streptozotocin on postnatal 28th day. 0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days. Blood glucose and body weight measurements, puberty follow-up and MWM tests were performed. Hippocampus, hypothalamus and testis were evaluated histologically. Hypothalamic GnRH and kisspeptin were studied immunohistochemically. Serum LH, FSH and insulin, hippocampal homogenate NGF and BDNF levels were determined by ELISA. Key findings: Delayed puberty was normalized by noopept (p < 0.05). Blood glucose levels were lower in noopept-administered diabetic groups (p < 0.05). Noopept decreased HOMA-IR in insulin administered diabetic group (p < 0.05). Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05). GnRH immunoreactivity in Diabetes + Noopept group was increased when compared to insulin + noopept group (p = 0.018). There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05). Significance: Noopept may have positive effect in treatment of pubertal diabetes.Öğe Effects of Noopept on Hippocampal NGF and BDNF Levels and Cognitive Functions of Prepubertal Rats with Streptozotocin-Induced Diabetes(Karger, 2018) Gurbuz, Perihan; Duzova, Halil; Kaya, Gul Busra; Cakan, Pinar; Durhan, Merve[Abstract Not Available]Öğe Effects of Viral Mimetic Polyinosinic-Polycytidilic Acid Injection on Plasma Corticosterone Levels in Female Rats(Wiley, 2018) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Erythrocyte transfusion restored heart rate variability in children with thalassemia major(Pergamon-Elsevier Science Ltd, 2021) Cakan, Pinar; Yildiz, Sedat; Akyay, Arzu; Oncul, YurdayThalassemia major (TM) is a severe transfusion-dependent anemia. Regular erytrocyte transfusion is required for the treatment of thalassemia patients. However, repeated transfusion may result in impairements in heart function. In this study, we aimed to investigate short-term effects of erythrocyte transfusion on autonomic control of heart in children with thalassemia major. For that purpose heart rate variability (HRV), which is a non-invasive method used to evaluate the effects of the autonomic nervous system on the heart rhythym, was measured before and after erythrocyte transfusion and compared to the healthy controls. Children diagnosed with TM (n = 17) and sex and age matched healthy children (HC, n = 30) were included in the study. HRV values of TM patients were measured 5 min before erythrocyte transfusion (BET, n = 17) and 5 min after erythrocyte transfusion (AET, n = 17). Parameters of time-domain and frequency-domain of HRV were evaluated in all participants. Heart rate (HR) was higher in the BET than AET (P = 0.002) but there was no difference between AET and HC groups (P > 0.05). HRV parameters were lower in BET than AET (P < 0.05) but there were no statistical difference between AET and HC (P> 0.05). The data suggest that, in thalassemia major patients, erythrocyte transfusion restores HR and HRV parameters to the levels observed in healthy controls and, thus, in short-terms, appears to be beneficial for the autonomic control of the heart.Öğe Gestational Viral Mimetic Administration in Rats does not Alter Leptin and Corticosterone Levels in Male Offspring(Wiley-Blackwell, 2016) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]Öğe Half- and Whole-Night Shift-Works May Differently Perturb Blood Parameters in Women(Wiley, 2017) Cakan, Pinar; Yildiz, Sedat[Abstract Not Available]