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    Evaluation of dynamic thiol-disulfide balance in children with stage 3-5 chronic kidney disease
    (2019) Cakirca, Gokhan; Nas, Cemal; Guzelcicek, Ahmet; Yilmaz, Kenan
    Aim: We aimed to examine dynamic thiol-disulfide balance, an indicator of oxidative stress, in children with stage 3-5 chronic kidney disease (CKD).Material and Methods: Native thiol (Nt), total thiol (Tt) and disulfide (DS) levels were determined spectrophotometrically in 27 children with CKD (14 non-dialysis, 13 hemodialysis) and 40 healthy controls.Results: Albumin, Nt, Tt and DS levels were markedly lower in CKD patients than in controls. However, the DS/Nt values were not statistically significant between the two groups. When Nt, Tt, DS and DS/Nt values were adjusted for albumin levels, Tt and Nt levels were lower in CKD patients than controls. In the CKD group, Nt and Tt levels were positively correlated with the albumin and estimated glomerular filtration rate and negatively with urea and creatinine. Conclusion: According to these results, decreased Nt and Tt levels in patients with CKD stages 3–5 may be evidence of exposure to oxidative stress. Keywords: Albumin; chronic kidney disease; thiol oxidation; thiol-disulfide balance.
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    Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats
    (2019) Pinar, Neslihan; Ozcan, Oguzhan; Dogan, Esin; Cakirca, Gokhan
    Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters.Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days.Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group. Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicity.Keywords: Oxidative stress; antioxidant; gentamicin; nephrotoxicity; dexpanthenol.