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Öğe Acute liver failure in adults(Aves, 2019) Caliskan, Ali Riza; Harputluoglu, Murat[Abstract Not Available]Öğe The aging kidney: A 10-year renal biopsy study of geriatric population(2019) Sahinturk, Yasin; Sarikaya, Metin; Dolu, Suleyman; Kok, Mehmet; Inci, Ayca; Caliskan, Ali RizaAim: To report our experience with the renal biopsy/complications and histopathologic patterns of renal diseases according to their clinical presentation and to make the best disease management in the elderly patients. Material and Methods: Totally 136 patients were analyzed according to their renal biopsy histopathology, clinical diagnosis and biopsy related complications between 2006 and 2016.Results: Nephrotic syndrome (NS) and acute kidney injury (AKI) were the leading indications for renal biopsy. Totally 65 patients (47%) were diagnosed as NS and 60 patients (44%) were AKI. The most frequent histopathologic diagnosis was amyloidosis (30%). Membranous nephropathy (22%) was the second frequent histopathologic diagnosis. Amyloidosis (18.3%) was the leading cause of nephrotic syndrome and membranous nephropathy (17.6%) was the second most seen cause. Amyloidosis (11%) was the mostly seen histopathologic diagnosis of AKI. Back pain longer than 12 hours (10%) was the most common complication.Conclusion: According to our findings, renal disease of elderly differs from other age groups according to histopathologic distribution, early renal function loss and rapid progression to end stage renal disease. For an accurate early diagnosis and initiating specific treatment, renal biopsy should be performed on an individual basis without an increased risk for renal biopsy related complications.Keywords: Acute kidney injury; nephrotic syndrome; renal biopsy; elderly; renal histopathology.Öğe Analysis of risk factors affecting the development of peptic ulcer perforation: case-control study(Termedia Publishing House Ltd, 2021) Akbulut, Sami; Caliskan, Ali Riza; Saritas, Hasan; Demyati, Khaled; Bilgic, Yilmaz; Unsal, Selver; Koc, CemalettinAim: The aim of the to determine the risk factors associated with increased risk of peptic ulcer perforation (PUP). Material and methods: The demographic, clinic, and biochemical parameters of 65 patients (PUP group) who underwent PUP surgery at our clinic between June 2009 and September 2016 were compared with the data of 134 patients (control group) who underwent endoscopy at a gastroenterology clinic for dyspeptic complaints. The control group were matched at random in a 1 : 2 ratio with the PUP group. Univariate analyses were used to compare different variables and variables with clinical significance, and p <= 0.05 was used in the backward stepwise logistic regression model. Results: This study included 65 patients with peptic ulcer perforation aged 17 to 92 years (PUP group) and 134 patients with dyspeptic complaints aged 18 to 87 years (control group). Univariate analysis showed that statistically significant differences were found between groups in terms of non-steroidal anti-inflammatory drugs usage (p = 0.042; OR = 1.868), smoking (p < 0.001; OR = 5.124), old age (p = 0.003), low body mass index (BMI) (p < 0.001), and low hemoglobin (Hb) (p = 0.002). However multivariate analysis showed that increasing age (p = 0.004; OR = 1.035), smoking (p = 0.007; OR = 3.591), decreasing Hb (p = 0.042; OR = 1.277), and decreasing BMI (p < 0.001; OR = 1.669) were independent clinically significant risk factors for development of PUP. Conclusions: This study showed that decreased BMI, decreased Hb, increased age, and smoking were independent risk factors for development of PUP. Thus, this group of patients needs particular attention paid to suggestive symptoms with early diagnosis and optimal management of peptic ulcer disease.Öğe Do hemoglobin levels affect the progression of chronic kidney disease in patients with stage 3-4 chronic kidney disease?(2019) Caliskan, Ali Riza; Sahinturk, Yasin; Ozdemir, Aygul; Sarikaya, MetinAim: We aimed in our study to evaluate the effect of anemia on renal progression in patients with stage 3-4 CKD. Material and Methods: A total of 88 patients, 44 females, and 44 males, were followed up in a pre-dialysis outpatient clinic with a diagnosis of stage 3-4 CKD. Forty-four of these patients had hemoglobin (HGB) value above 12 g/dL, whereas 44 of them had a value between 10-12 g/dL. We accepted the first group as normal and the second group as mild anemia. We followed up the mild anemia group without Erythropoietin (EPO) treatment. Glomerular filtration rate (GFR) values were calculated with BUN, creatinine, hemoglobin, albumin and uric acid levels that had been measured in four months periods. GFR values were calculated using the MDRD formula. The follow-up duration of the two groups was twelve months. Results: Initial, fourth, eighth and twelfth months GFR values of the patients were calculated. There was no significant difference (F=1.242, p>0.05) between the GFR values of first, fourth, eighth, and twelfth months controls. GFR values measured at four different times were similar. Also, the GFR values showed no difference between the HGB groups (F=1.892, p>0.05). HGB levels did not affect GFR values measured at different times. Conclusion: It is thought that in stage 3-4 CKD, maintenance of-HGB level at 10-12 g/dL or above 12 g/dL had a similar effect on renal progression. During the follow-up of CKD, HGB level above 10 g/dL is sufficient for controlling the progression of CKD.Öğe Effects of larazotide acetate, a tight junction regulator, on the liver and intestinal damage in acute liver failure in rats(Sage Publications Ltd, 2021) Caliskan, Ali Riza; Gul, Mehmet; Yilmaz, Ismet; Otlu, Baris; Uremis, Nuray; Uremis, Muhammed Mehdi; Kilicaslan, IlkayBackground and Aim The epithelial cells are the strongest determinants of the physical intestinal barrier. Tight junctions (TJs) hold the epithelial cells together and allow for selective paracellular permeability. Larazotide acetate (LA) is a synthetic octapeptide that reduces TJ permeability by blocking zonulin receptors. In this study, we aimed to investigate the effects of LA, a TJ regulator, on the liver and intestinal histology in the model of acute liver failure (ALF) in rats. Materials and Methods The thioacetamide (TAA) group received intraperitoneal (ip) injections of 300 mg/kg TAA for 3 days. The TAA+LA(dw) (drinking water) group received prophylactic 0.01 mg/mL LA orally for 7 days before the first dose of TAA. The LA(dw) group received 0.01 mg/mL LA orally. The TAA + LA(g) (gavage) group received prophylactic 0.01 mg/mL LA via oral gavage for 7 days before the first dose of TAA. The LA(g) group received 0.01 mg/mL LA via oral gavage. While liver tissue was evaluated only with light microscopy, intestinal samples were examined with light and electron microscopy. Results Serum ammonia, AST, and ALT levels in the TAA group were significantly higher than in control groups (all p < 0.01). Serum ALT levels in the TAA + LA(dw) group were significantly lower than in the TAA group (p < 0.05). However, serum ammonia and ALT levels did not differ between the TAA and other groups. Serious liver damage in the TAA group was accompanied by marked intestinal damage. There was no significant difference between the TAA and TAA + LA(dw) groups and TAA and TAA + LA(g) groups for liver damage scores. However, intestinal damage scores significantly decreased in the TAA + LA(dw) group compared to the TAA group. In the TAA + LA(dw) group, fusion occurred between the surface epithelial cells of neighboring villi and connecting regions formed as epithelial bridges between the villi. Conclusion Our findings suggest that LA reduced intestinal damage by acting on TJs in the TAA-induced ALF model in rats.Öğe Endoscopic treatment of biliary complications in donors after living donor liver transplantation in a high volume transplant center(Aves, 2020) Erdogan, Mehmet Ali; Cagin, Yasir Furkan; Atayan, Yahya; Bilgic, Yilmaz; Yildirim, Oguzhan; Caliskan, Ali Riza; Aladag, MuratBackground/Aims: Although living donor liver transplantation (LDLT) has been accepted as a primary treatment for adults with endstage liver disease, concerns about donor health have emerged. As LDLT is technically complex, it creates perioperative morbidity and mortality risk in donors. Biliary complications such as stricture and leakage are seen most frequently in donors after liver transplantation. While some of these complications get treated with a conservative approach, endoscopic, surgical, and percutaneous interventions may be required in some others. We aimed to present endoscopic retrograde cholangiopancreatography (ERCP) results in donors who developed biliary complications after LDLT. Materials and Methods: Between June 2010 and January 2018, a total of 1521 donors (1291 right lobe grafts, 230 left lobe grafts) who underwent LDLT were retrospectively reviewed. Sixty-three donors who underwent ERCP due to biliary complication were included in the study. Results: Biliary stricture was found in 1.6% (25/1521), biliary leakage in 2.1% (33/1521), and stricture and leakage together in 0.3% (5/1521) donors. Our endoscopic success rates in patients with biliary leakage, biliary stricture, and stricture and leakage were 85% (28/33), 92% (23/25), and 80% (4/5), respectively. Surgical treatment was performed on 12.6% (8/63) donors who failed ERCP. Conclusion: We found that ERCP is a successful treatment for post-LDLT donors who have biliary complications.Öğe Evaluation of stent applications for upper gastrointestinal disorders(2024) Caliskan, Ali Riza; Yildirim, OguzhanAim: Gastrointestinal stents are predominantly used for palliating malignant dysphagia in patients with esophageal cancer when surgical intervention is deemed inappropriate. This research aims to elucidate the diagnostic and follow-up processes of patients who underwent stent placement for upper gastrointestinal system pathologies at our clinic. Materials and Methods: A retrospective analysis assessed 61 patients who received stents for upper gastrointestinal tract stenosis due to various causes. Patient demographics, including age and gender, underlying pathology, benign-malignant status, location of the pathology, prior surgical or bougie dilation interventions, post-stent survival status, and, if applicable, the duration between the procedure and decease, were evaluated. Patient health records were accessed from the hospital’s electronic medical database. Results: Pre-stent bougie dilation was performed in 26.2% (n=16) of patients, while pre-stent surgery was undertaken in 41% (n=25). Repeat stenting was necessitated in 6.6% (n=4) of cases. Of the patients, 86.9% (n=53) succumbed to their condition, while 13.1% (n=8) survived. Post-stent survival times for deceased patients after stent surgery ranged from 0 to 55 months, with a median survival time of two months. Surviving patients exhibited varied post-stent durations between 65 and 122 months, with a mean stent utilization period of 101 months. A statistically significant correlation was observed between pre-stent surgery and survival status, indicating a higher surgery rate in patients who survived than those who did not (p<0.05). Conclusion: Consequently, due to its cost-effectiveness, stents can be a viable alternative to surgery for both benign and malignant gastrointestinal disorders. This is attributed to its notable advantages, including flexibility and high resistance.Öğe Fingolimod induced fulminant liver failure requiring liver transplantation: A case report(Kare Publ, 2023) Caliskan, Ali Riza; Harputluoglu, Muhsin Murat Muhip; Samdanci, Emine; Cirik, Salih; Yilmaz, SezaiFingolimod has been used for about ten years to treat multiple recurrent sclerosis. It has been reported that Fingolimod causes an elevation in liver enzymes. In this case report, the clinical and laboratory parameters improved after discontinuation of the drug. However, there is no publication in the literature regarding acute liver failure and liver transplantation following Fingolimod treatment. In this article, we presented a 33 - year - old female patient who developed acute liver failure and underwent liver transplantation after Fingolimod treatment for recurrent multiple sclerosis.Öğe Gastrointestinal amyloidosis occurring in three different patterns: Case serie(2019) Cagin, Yasir Furkan; Caliskan, Ali Riza; Bilgic, Yilmaz; Yildirim, Oguzhan; Erdogan, Mehmet Ali; Seckin, Yuksel; Alan, Saadet; Karadag Soylu, NeseSystemic amyloidosis is a rare disease characterized by extracellular accumulation of amyloid protein in one or more organs. In patients with systemic amyloidosis, the most frequently affected organs are kidney and heart, followed by the nervous system, soft tissues, and lungs. Small bowel and liver involvement are also frequent in systemic amyloidosis. Gastrointestinal (GI) findings are common, and the degree of organ involvement determines the symptoms. Patients usually have nonspecific findings such as abdominal pain, nausea, diarrhea, and dysphagia, which may delay the appropriate diagnosis. Liver involvement occurs in the majority of patients, but the symptoms typically do not happen unless a marked hepatic amyloid deposition occurs. Diagnosis is by tissue biopsy. Treatment and prognosis depend on the underlying disease. GI system involvement is a sign of poor prognosis. In this case series, five patients who were diagnosed with gastrointestinal system amyloidosis in our clinic are presented.Öğe Larazotide acetate reduces the frequency of bacterial translocation in the thioacetamide-induced liver failure in rats(Elsevier, 2020) Caliskan, Ali Riza; Harputluoglu, Muhsin Murat; Otlu, Baris; Gul, Mehmet; Ozerol, Elif; Uremis, Nuray; Dertli, Ramazan[Abstract Not Available]Öğe Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study(Lippincott Williams & Wilkins, 2021) Efe, Cumali; Dhanasekaran, Renumathy; Lammert, Craig; Ebik, Berat; Higuera-de la Tijera, Fatima; Aloman, Costica; Caliskan, Ali RizaBackground and Aims Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking. Approach and Results We performed a retrospective study on patients with AIH and COVID-19 from 34 centers in Europe and the Americas. We analyzed factors associated with severe COVID-19 outcomes, defined as the need for mechanical ventilation, intensive care admission, and/or death. The outcomes of patients with AIH were compared to a propensity score-matched cohort of patients without AIH but with chronic liver diseases (CLD) and COVID-19. The frequency and clinical significance of new-onset liver injury (alanine aminotransferase > 2 x the upper limit of normal) during COVID-19 was also evaluated. We included 110 patients with AIH (80% female) with a median age of 49 (range, 18-85) years at COVID-19 diagnosis. New-onset liver injury was observed in 37.1% (33/89) of the patients. Use of antivirals was associated with liver injury (P = 0.041; OR, 3.36; 95% CI, 1.05-10.78), while continued immunosuppression during COVID-19 was associated with a lower rate of liver injury (P = 0.009; OR, 0.26; 95% CI, 0.09-0.71). The rates of severe COVID-19 (15.5% versus 20.2%, P = 0.231) and all-cause mortality (10% versus 11.5%, P = 0.852) were not different between AIH and non-AIH CLD. Cirrhosis was an independent predictor of severe COVID-19 in patients with AIH (P < 0.001; OR, 17.46; 95% CI, 4.22-72.13). Continuation of immunosuppression or presence of liver injury during COVID-19 was not associated with severe COVID-19. Conclusions This international, multicenter study reveals that patients with AIH were not at risk for worse outcomes with COVID-19 than other causes of CLD. Cirrhosis was the strongest predictor for severe COVID-19 in patients with AIH. Maintenance of immunosuppression during COVID-19 was not associated with increased risk for severe COVID-19 but did lower the risk for new-onset liver injury during COVID-19.Öğe Protective Effect of Canaboid Type 2 Receptor Agonist (JWH-133) Against Hepatic Endoplasmic Reticulum Stress Induced by Prangos Ferulacea Extract(Wiley, 2022) Celik, Mesut; Duzova, Halil; Karaca, Zeynal Mete; Tasidere, Asli Cetin; Gecibesler, Ibrahim Halil; Caliskan, Ali Riza[Abstract Not Available]Öğe A STUDY OF ACUTE LIVER INJURY ASSOCIATED WITH ORNIDAZOLE: ANALYSIS OF 82 CASES IN TURKIYE(Lippincott Williams & Wilkins, 2023) Turan, Ilker; Durmazer, Esra Nur Nur; Vatansever, Sezgin; Caliskan, Ali Riza; Harputluoglu, Murat; Efe, Cumali; Idilman, Ramazan[Abstract Not Available]
