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    Claudin-5 (tight junction) expression level changes in achilles tendon healing
    (2019) Cirakli, Alper; Cirakoglu, Derya; Erdem, Havva; Uzun, Erdal; Cankaya, Soner
    Aim: This study aimed to reveal the relationship between changes in Claudin-5 expression and the duration of healing in Achilles tendon injury. Material and Methods: 18 Achilles tendons of Wistar-Albino rats were used in the study. Rats were divided into 3 groups as 6 rats in each group, group 1; sham group, group 2; tendon repair group (sacrificed after 3 weeks), group 3; tendon repair group (sacrificed after 6 weeks). Immunohistochemically, the tendons were stained with Claudin-5 and the degree of staining with light microscope was rated between 0 and 3. The obtained scores were compared with Kruskal Wallis test and Posthoc analysis. Results: The scores were 0.5 ± 1 (0-1) in group 1.1 ± 1 (1-2) in group 2 and 1.5 ± 1 (1-2) in group 3. A statistically significant difference was found between the groups (p = 0.026). In the posthoc analyzes, there was a significant difference between group 1 and 3, but there was no significant difference between groups 1 and 2 and between groups 2 and 3. Conclusion: The expression of claudins is regulated by many factors, including hormones, various cytokines, and epithelialmesenchymal transition-related transcription factors. In this study, the increase in the expression of Claudin-5 was noticed in proportion to the progress of primary wound healing. This relationship may be a part of the repair mechanism. The role of claudin levels in intercellular passage is crucial for function as it is important for cell signaling. Achilles tendon healing can be attributed to a laboratory parameter such as claudin. This can help to understand the recovery rate and can help early return to work or sport. We believe that as a laboratory parameter Claudin-5 may be useful in the evaluation of tendon healing.
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    Evaluation of cardiometabolic function with serum adropin levels in psoriasis patients
    (2021) Onder, Sevda; Bayrak, Tulin; Kaya, Yasemin; Cankaya, Soner; Ozturk, Murat
    Aim: Psoriasis is a skin disease with metabolic and cardiac comorbidities. Adropin is a peptide hormone which is thought to play a role in metabolic diseases, energy homeostasis, endothelial function and cardiac diseases in recent years. In this study, we aimed to evaluate adropin levels in psoriasis patients Materials and Methods: The study included 51 plaque psoriasis patients aged 18-65 years who had no systemic disease and had not received systemic treatment in the last three months and 37 healthy controls matched by sex, age and body mass index (BMI). Serum adropin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG), fasting blood glucose (FBG), fasting serum insulin, BMI, systolic blood pressure (SBP) and diastolic blood pressure (DBP) values were recorded. Results: Serum adropin level was 73.04 ± 46.21 pg / ml in the patient group. In the control group, serum adropin level was 77.26 ± 43.69 pg / ml. Serum adropin levels were lower in the patient group, but this was not statistically significant (p = 0.667). PASI value was negatively correlated with serum adropin level. There was no correlation between serum adropin level and other variables. Insulin level, Homa-IR level, systolic and diastolic pressure were significantly higher in the patient group (p <0.05). Conclusion: In our study, although adropin levels were not significantly lower in the patient group, we concluded that this may be associated with low PASI values. The role of adropin in psoriasis vulgaris will emerge with further studies.