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    Complete Blood Count parameters could predict malignancy in breast lesions
    (2020) Ozer, Bahri; Catal, Oguz; Peltek Ozer, Songul; Keyif, Fatih; Sit, Mustafa; Kama, Nuri
    Aim: Inflammatory response plays an important role in the development and progression of various cancers, including breast cancer. The aim of present study is determining Complete Blood Count parameters as possible predictors of malignancy in breast lesions. Material and Methods: Patients with BI-RADS-4 breast disease were studied between 2010 and 2017 retrospectively. Patients with lesions detected radiologically were included in the study. According to the histopathological results, the study cohort was divided into two groups, either benign or malignant. Final blood counts of the patients before pre-biopsy were evaluated in preoperative peripheral blood measurements. When blood was taken, care was taken not to have other causes of leukocytosis in the patient. Complete Blood Count parameters were compared in these groups. Results: A total of 331 women with BI-RADS 4 lesions enrolled to the study. Mortality and morbidity were not observed after breast biopsy in patients. Platelet (p=0.04), platelet to lymphocyte ratio (p=0.006) and red cell distribution width to platelet ratio (p=0.032) values of the patients with BI RADS 4A were found significantly different in the malignant group compared to benign BI RADS 4A group. In total BIRADS 4 lesions, the ratio of PLT and RPR was significant in malignant group (p=0.047, p=0.002) in Complete Blood Count parameters compared benign and malignant group. Conclusion: Studies have shown that cancer affects peripheral blood cells positively or negatively. In our study, among peripheral blood cells, platelets were found to be the most affected in cancer patients. The PLT, PLR and RPR values could be valuable in predicting malignant BIRADS 4 breast lesions.
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    The role of monocyte to lymphocyt ratio in predicting metastasis in rectal cancer
    (2021) Catal, Oguz; Ozer, Bahri; Sit, Mustafa; Aktas, Gulali; Erkol, Hayri
    Aim: A lot of studies are being carried out to predict recurrence and metastasis in rectal cancer, which is a common type of cancer in general surgery practice. It is thought that MLR (monocyte to lymphocyte ratio) , an indice developed by division of monocyte count by lymphocyte count, may be a good marker to reflect the degree of tumor progression and predict prognosis. In our study, we investigated the role of MLR in predicting metastasis in rectal cancer.Materials and Methods: Fifty-seven patients diagnosed with rectal cancer in the Abant Izzet Baysal University general surgery clinic between 2012 and 2016 were retrospectively investigated. Albumin, CRP(C reactive protein), Platelet, Neutrophil, Lymphocyte, Monocyte values were obtained as the inflammatory markers in the blood count test of the patients before neoadjuvant treatment.Results: In this study, 25 patients who underwent neoadjuvant chemoradiotherapy and underwent full postoperative follow-up were evaluated. Eight of these 25 patients had metastasis until June 2019. There was a significant difference in monocyte and MLR values between groups with and without metastasis.Conclusion: This study is presented as a preliminary study. In our study, we showed that MLR value which measured before neoadjuvant therapy in rectum cancer patients may be useful in predicting metastasis development.