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    The evaluation of dose distribution of vertebral growth plates in pediatric patients who underwent craniospinal radiotherapy
    (2019) Catli Dinc, Serap; Ucgul, Aybala; Senturk, Ertugrul
    Aim: The aim of this study was to evaluate the suitability of the dose distribution of vertebral growth plates in pediatric patients undergoing craniospinal radiotherapy with the recommendations of the SIOPE radiotherapy study group.Material and Methods: The study included 20 patients under the age of 12 who underwent 3-dimensional conformal craniospinal radiotherapy. For each patient, posterior and anterior primary ossification center of the cervical, thoracal, lumber and sacral vertebrae regions were re-contoured .The mean doses of each primary ossification center were determined and then the gradients were determined. The difference between the average doses of the anterior and posterior ossification centers of the vertebrae was evaluated separately for the cervical, thoracic, lumbar and sacral regions. Data were analyzed with descriptive statistics.Results: The mean doses of the posterior and anterior primary ossification center were respectively 23.62 Gy and 22.54 Gy for those lower than 25 Gy and 34.06 Gy and 33.09 Gy for those who underwent a dose greater than 25 Gy. The dose differences of the anterior and posterior ossification centers in the cervical, thoracal, lumbar and sacral vertebrae is lower than 5 Gy for those who underwent lower dose than 25 Gy.Conclusion: The planning data of craniospinal radiotherapy, which is applied to the cranial region with two lateral fields and the spinal area with single field, complies with the SIOPE recommendations.Primary and secondary ossification centers should be identified as the organ at risk for radiotherapy planning in the pediatric group undergoing craniospinal radiotherapy.Keywords: CSRT; vertebral primary ossification centers; radiotherapy dose distribution.
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    Experimental and Monte Carlo evaluation of effects of temporary tissue expanders (TTE) on radiotherapy dose distribution
    (2020) Catli Dinc, Serap
    Aim: The purpose of this study was to model the metallic port which included samarium cobalt magnet in breast tissue expanders and to improve the accuracy of dose calculations with nanoDot optically stimulated luminescence dosimeter (nanoDot OSLD) measurements.Material and Methods: Mentor TTE (Temporary Tissue expander) (at a depth of 3 cm) was modeled by DOSXYZnrc Monte Carlo code and the nanoDot OSLD were used for dose measurements in solid water phantoms.Results: In present study, dose increases in tissue at 3 cm due to the backscatter of electrons was 16.3% for metallic port at 6 MV using the Monte Carlo method. It was observed 12 % in the experimental results. Additionally, while the decrease in dose behind the port was 17.4 % by Monte Carlo program code, it was observed 25.8 % in the experimental results Conclusions: In present study, the low dose region remains in saline solution within the tissue expander. It can be negligible clinically. In a clinical setting, the breast patients are treated with tangent beam fields. It was thought that unless the frontal direct field was not used in clinics for these patients, the dose reduction and dose increase would not do not play a role in influencing the treatment.