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    Adrenomedullin and total nitrite levels in children with acute rheumatic fever
    (Pergamon-Elsevier Science Ltd, 2005) Balat, A; Kilinc, M; Cekmen, MB; Güler, E; Yürekli, M; Sahinöz, S; Coskun, Y
    Objective: To investigate the levels of adrenomedullin (AM) and total nitrite, a stable product of nitric oxide (NO), in children with acute rheumatic fever (ARF). Design and methods: Eleven children with ARF were investigated in comparison with 14 healthy controls. Adrenomedullin was detected by HPLC, while total nitrite was quantitated by the Griess reaction. Results: Plasma urinary AM and total nitrite levels were significantly higher in children with ARE, irrespective of whether they were in the acute or convalescent phase of disease. Plasma AM (pmol/mL) levels were 49.19 +/- 3.23 in the acute phase, 44.52 +/- 4.26 in the convalescent phase, 35.49 +/- 3.43 in controls, and urinary AM excretion (pmol/mg creatinine) was 43.45 +/- 18.40 in the acute phase, 32.38 +/- 15.37 in the convalescent phase, and 24.84 +/- 11.38 in controls. Plasma total nitrite levels (mu mol/L) were 75.37 +/- 13.13 in the acute phase, 59.81 +/- 12.78 in the convalescent phase, and 41.09 +/- 10.27 in controls. Urinary total nitrite excretion (mu mol/mg creatinine) was 3.82 +/- 1.56 in the acute phase, 2.15 +/- 0.58 in the convalescent phase, and 1.33 +/- 0.61 in controls. The differences were statistically significant for all (P < 0.05). Conclusion: This study considered that AM and NO may have a role in the immunoinflammatory process of ARF. (c) 2005 The Canadian Society of Clinical Chemists. All rights reserved.
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    Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women
    (Pergamon-Elsevier Science Ltd, 2004) Cekmen, MB; Balat, A; Balat, O; Aksoy, F; Yurekli, M; Erbagci, AB; Sahinoz, S
    Objective: To observe the adrenomedullin (AM) and total nitrite levels in the milk of preeclamptic and normal pregnant women. Design and methods: Fifteen women with preeclampsia and 15 normal pregnant women were included in the study. Total nitrite was quantitated by Griess reaction, while AM was measured by HPLC. Results: The levels of AM and total nitrite in colostrum and 30th-day breast milk were decreased in preeclamptics. Total. nitrite levels (mumol/l) were 56.09 +/- 11.18 vs. 82.20 +/- 12.01, P < 0.05, in colostrum of preeclamptics and controls, respectively. The level of total nitrite was 37.75 +/- 12.10 vs. 53.28 +/- 10.25, P < 0.05, in 30th-day milk of same patients. AM levels (pg/ml) were 11.18 +/- 1.11 vs. 16.59 +/- 1.24, P < 0.0001, in colostrum of preeclamptics and controls, respectively. In 30th-day milk of same patients, AM levels were 8.41 +/- 1.39 vs. 12.18 +/- 1.48, P < 0.005, respectively. Conclusion: This report shows for the first time that human milk has decreased levels of AM and total nitrite in preeclampsia. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.