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    The chromosomal abnormalities associated defects and outcomes of fetuses diagnosed prenatally with clubfoot
    (2021) Obut, Mehmet; Tolunay, Harun Egemen; Yucel Celik, Ozge; Cayonu Kahraman, Neval; Arat, Ozgur; Ozlu Unal, Merve; Celen, Sevki
    Aim: To assess associated findings, chromosomal abnormalities and outcomes of the pregnancies diagnosed with fetal clubfoot. Materials and Methods: Ultrasonographic characteristics, pregnancy work-up and fetal outcomes of the pregnancies diagnosed with fetal clubfoot between January 2015 and October 2019 were evaluated retrospectively. Clubfoot was considered as complex or isolated depending on the presence or absence of additional structural abnormalities. The results of cases, which grouped according to the presence of additional abnormalities and laterality, were compared. Results: A total data of 46 pregnancies diagnosed with fetal clubfoot during the study period were included. The most associated abnormality with clubfoot was central nervous system (CNS) anomalies. Nineteen (41%) of fetuses were considered complex, and 27 (59%) were considered isolated. The ratio of the cases with poor outcomes was higher in the complex group than in the isolated group and was 15 (79%) and 1(3%) respectively (p=0.000 for bilateral group and p=0.013 for unilateral group). There were 7 (36%) cases with a chromosomal abnormality in the complex group and 1(4%) case in the isolated group. The deformity was unilateral in 16 (35%) and bilateral in 30 (65%) cases. The rate of poor outcomes was not different in cases with bilateral and unilateral clubfoot deformity (p=0.356). Conclusion: The prognosis of the fetuses diagnosed with clubfoot mostly depends on associated abnormalities. Therefore a careful evaluation of these fetuses must be performed even if karyotyping is normal. The laterality did not have any impact on the prognosis of cases with clubfoot.
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    Frequency of hereditary thrombophilia, anticoagulant activity, and homocysteine levels in patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome
    (Wiley, 2011) Dogan, Ovgu Ozkan; Simsek, Yavuz; Celen, Sevki; Danisman, Nuri
    Aim: The purpose of this study was to investigate the correlations between thrombophilic mutations, anticoagulant activity and hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome. Material and Methods: Twenty-five healthy pregnant women (control group) and 34 patients with HELLP syndrome (study group) were included in the study between April 2007 and January 2008. Homocysteine levels and activities of protein C, protein S and antithrombin III of the groups were compared. Frequency of factor V Leiden mutation, prothrombin 20210A mutation and C677 T mutation of methylenetetrahydrofolate reductase gene were also compared. Results: Frequencies of thrombophilic gene mutations of the two groups were not significantly different. Homocysteine levels were significantly higher in the study group. Protein C and protein S deficiencies of the two groups were similar. Antithrombin III deficiency was statistically higher in the patients with HELLP syndrome. Conclusion: The frequency of antithrombin III deficiency and homocysteine levels were higher in the patients with HELLP syndrome; however, there was no positive relationship between hereditary thrombophilic mutations and the disease. Larger prospective studies are needed to validate our findings.
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    Labor and birth outcomes in term low-risk adolescent pregnancies
    (2020) Oskovi Kaplan, Zeynep Asli; Ates, Mete Can; Buyuk, Gul Nihal; Sert Dinc, Umit Yasemin; Celen, Sevki; Topcu, Hasan Onur
    Aim: The study aimed to evaluate the relationship between the caries frequency, which was determined using different caries indexes Objective: The aim of this study was to investigate the effect of in-office bleaching agents on the color and translucency of different resin composites. Materials and Methods: Twenty-four disk-shaped specimens with 1 mm thickness and 8 mm diameter were fabricated from five different resin composites. The specimens were then divided into three subgroups, two office bleaching groups (40% Opalescence Boost, 38% Whitesmile Power Whitening) and one control group (n=8). All specimens were polymerized for 40 s with a LED light-curing unit. Color measurement was performed using a spectrophotometer. Bleaching agents were applied to the experimental groups in accordance with the manufacturer's instructions for 14 days, while the specimens in the control group were kept in distilled water only. Translucency parameters of the specimens before and after bleaching and the color changes after bleaching were calculated using CIE L*a*b* color coordinates. Data were analyzed using the paired sample t-test and ANOVA (α=0.05).Results: Statistically significant differences were found between the control group and the bleached groups according to color change values (p0.05). The highest mean color change value was observed in the Ceram-X / Opalescence Boost group. The Ceram-X / Opalescence Boost, Majesty Esthetic / Opalescence Boost, and Ceram-X / Whitesmile Power specimens showed clinically non-acceptable color changes. Translucency parameter values in each group between baseline and the end of the 14th day revealed no statistically significant difference (p>0.05).Conclusions: The office bleaching agents may affect the color and translucency parameters of composite resins depending on the structural properties.