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    A case-control study on effects of the ATM, RAD51 and TP73 genetic variants on colorectal cancer risk
    (Walter De Gruyter Gmbh, 2019) Yazici, Merve; Yilmaz, Umit; Yilmaz, Nesibe; Celik, Faruk; Isikoren, Ece Gizem; Celikel, Burcu; Ergen, Arzu
    Aim: ATM, RAD51 and TP73 are genes that take part in DNA repair pathways. The aim of this prospective case-control study was to determine the genotype and allele distributions of the ATM 5'-UTR G/A, RAD51 135 G/C and TP73 GC/AT polymorphisms and their relationship with clinical parameters in Turkish colorectal cancer (CRC) patients. Material and methods: One hundred and four CRC patients and 113 healthy individuals were included in this study as control. The polymerase chain reaction-restriction fragment length polymorphism techniques were used. Results: The ATM 5'-UTR G/A polymorphism GG (p = 0.001) and AA (p = 0.0001) genotypes were found higher in the patient group, while the GA genotype (p = 0.0001) and A allele (p= 0.001) were significantly higher in the control group. Moreover, the GG genotype (p = 0.042) was higher among patients with advanced-stage cancer and, while GA genotype (p = 0.047) was increased in patients without perineural invasion. The RAD51 135 G/C polymorphism GC genotype (p= 0.0001) and C allele (p = 0.0001) were significantly higher in the patient group, while CC genotype (p= 0.0001) was higher in the control group. No statistical significance was observed between the TP73 GC/AT polymorphism genotype and allele distribution and the clinical parameters. Conclusion: In the Turkish population, the ATM 5'-UTR GG and AA genotypes, and the RAD51 135 G/C GC genotype and the C allele presence may be risk factors for CRC.