Yazar "Celik, Fatih" seçeneğine göre listele

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    Evaluation of central macular thickness after penetrating keratoplasty
    (2018) Can, Nagehan; Guler, Mete; Yusufoglu, Elif; Celik, Fatih; Gul, Fatih Cem; Ozsoy, Ercan
    Aim: To evaluate the changes in central macular thickness after penetrating keratoplasty. Material and Methods: A total of 24 eyes of 24 patients who had undergone penetrating keratoplasty were included in the study. This study was performed retrospectively by reviewing the charts of the patients. Postoperative 1st week, 1st month, 3rd month, 6th month and 12th month mean total macular volume, central macular thickness, parafoveal area and perifoveal area thickness and retinal nevre fiber layer (RNFL) thickness results obtained with optic coherence tomography were compared. ANOVA test was used for statistical analysis. Results: The postoperative 1st week, 1st month, 3rd month, 6th month and 12th month mean total macular volume measurements were 7.03±0.2 mm³, 7.05±0.4 mm³, 7.0±0.6 mm³, 7.02±0.5 mm³ and 6.12±0.6 mm³, respectively. Mean central macular thickness measurements were 227.6±4.6 μm, 228.7±5.5 μm, 227.2±4.6 μm, 227.5±7.1 μm, 226.3±5.1μm respectively; mean parafoveal area thickness measurements were 290.2±3.7 μm, 289.9±7.8 μm, 288.7±6.3 μm, 288.8±4.7 μm, 288.6±8.3 μm respectively, mean perifoveal area thickness measurements were 261.1±4.2 μm, 261.4±1.9 μm, 260.4±3.6 μm, 259.8±2.7 μm, 259.3±4.7 μm respectively, and mean RNFL thickness measurements were 106.54±11.28 μm, 107.28±8.75 μm, 107.45±13.64 μm, 105.62±9.27 μm, 105.16±12.74 μm; respectively. Conclusion: No significant change was seen in macular thickness after penetrating keratoplasty. Although the macular thickness increases in the early postoperative stage, it decreases in time.
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    Evaluation of retinal and choroidal thickness in various age groups
    (2018) Celik, Fatih; Ulas, Fatih; Kaymaz, Abdulgani; Ozsoy, Ercan
    Aim: To evaluate retinal and choroidal thickness of healthy individuals in various age groups with optical coherence tomography (OCT) and enhanced depth imaging (EDI)-OCT technique . Material and methods: Totally 149 healthy patients aged between 0 and 69 years from seven different decades were included in this study. The retinal and choroidal thickness of the central area (fovea) and of the nasal and temporal points at a distance of 1500 μm from this central point were measured in the right eye with an OCT device (Heidelberg, Germany) in all subjects. The subjects with any ocular or systemic pathology and the subjects with a spherical refractive error more than 3 D or a cylindrical refractive error more than 1 D were excluded. The measurements of right eyes of the subjects were used in the statistical analysis and the P value less than 0.01 was considered to be significant. Results: The mean retinal thickness measurements were 326.61±16.89 µm at the temporally, 218.72±19.06 µm centrally and 351.32±17.74 µm nasally, with no statistically significant difference between the age groups (p˃0.01). The mean choroidal thickness measurements were 299.01±72.38 µm temporally, 332.34±78.08 µm centrally and 258.30±71.80 µm nasally. There were statistically significant differences in central and temporal choroidal thickness between age groups (p˂0.01). Conclusion: A statistically significant decrease was present in the choroidal thickness but not in the retinal thickness with age.
  • Küçük Resim Yok
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    Synthesis, characterization, and biological activity of novel 1,2,4-triazole moieties: Antileishmanial, antimicrobial effects, and molecular docking studies
    (Elsevier, 2024) Suleymanoglu, Nevin; Unver, Yasemin; Ustabas, Resat; Celik, Fatih; Guler, Halil Ibrahim; Direkel, Sahin; Bektas, Kadriye Inan
    In this study; new 1,2,4-triazole derivatives, (E)-4-(((3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino) methyl)phenyl 4-methoxybenzoate (3a), (E)-4-(((3-benzyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)imino) methyl)phenyl 4-methoxybenzoate (3b) and (E)-4-(((3-(4-fluorobenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl) imino)methyl)phenyl 4-methoxy benzoate methoxy benzoate (3c) were synthesized and characterized by FTIR and NMR (1H- and 13C-) spectroscopic methods. Structural and spectral parameters were calculated by DFT/ B3LYP/6-311++G(d,p) methods. The newly synthesized compounds 3a-3c were evaluated for their antimicrobial activities against eight pathogenic microorganisms. Standard commercial drugs ampicillin and fluconazole were used as references for bacteria and yeast, respectively. The leishmanicidal activity of three different synthesized compounds against Leishmania infantum promastigotes was investigated using the microdilution method. In addition, the study attempted to investigate the interactions crucial for the antileishmanial activity of compound 3b by molecular docking analysis targeting trypanothione reductase (TRe).