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Öğe Assessment of quantitative zonal parameters of prostate gland in discrimination of normal, benign, and malignant conditions: are these the more reliable parameters in the diagnosis of prostate cancer?(Verduci Publisher, 2023) Karaca, L.; Ozdemir, Z. M.; Kahraman, A.; Celik, H.; Kaya, S.OBJECTIVE: Prostate cancer diagnosis and treatment are increasing in current public healthcare programs. An improved resolution multiparametric magnetic resonance imaging (MRI) has shown the potential to enhance the detection and differentiation of this medical condition. In this study, MR perfusion parameters were investigated in different ages and diseases to differentiate clinically significant prostate cancer.PATIENTS AND METHODS: From January 2017 to December 2022, 72 consecutive patients, who had undergone multiparametric MR imaging were enrolled in this study. Four different patient groups were formed: (1) those with prostate cancer, (2) those with prostatitis, (3) those with benign prostate hyperplasia (BPH), and (4) a control group. Quantitative dynamic contrast-enhanced (DCE)-MRI pharmacokinetic parameters included Ktrans, Kep, Ve, and iAUG. Different measurements were obtained from both the peripheral and transitional zones (PZ and TZ, respectively). Means values were compared between groups based on a univariate analysis.RESULTS: Ktrans and Kep values in the PZ were found to be statistically significantly lower in the control group (p = 0. 003 and p = 0. 011, respectively). It was seen that Ktrans and Ve measurements obtained from PZ had a statistically significant determinant in detecting malignancy (p = 0. 013 and p = 0. 036, respectively). It was seen that Ktrans, Ve, and iAUG obtained from the TZ showed a statistically significant difference in prostate cancer (p = 0.025, p = 0.005, and p = 0. 011, respectively) in contrast to other cases. Peripheral Ve values were statistically significantly lower than those measured Ve values from the TZ in prostate cancer cases (p = 0.002) in contrast to the other cases.CONCLUSIONS: Quantitative DCE-MRI parameters may vary according to age, disease, and zonal anatomy. These differences may contribute to the diagnosis of clinically relevant prostate cancer.Öğe Effect of intraoperative irrigation with alteplase on adhesion formation associated with intraperitoneal chemotherapy (experimental study)(I R O G Canada, Inc, 2008) Meydanli, M. M.; Celik, H.; Hanay, F.; Nalbant, M.Objective: To examine the efficacy of intraoperative irrigation with alteplase, a tissue plasminogen activator, for the prevention of adhesion formation associated with intraperitoneal chemotherapy. Material and Methods: Rats, in which serosal injury was induced in the right uterine horn and ipsilateral parietal peritoneum, were randomly divided into four groups. Group I (n = 10) had intraoperative intraperitoneal irrigation with alteplase following the standard operation. Group 11 (n = 10) had irrigation with normal saline, while the rats in Group III (n = 10) and Group IV received no peritoneal irrigation. All rats, except for those in Group IV, received intraperitoneal (IP) paclitaxel plus carboplatin chemotherapy on the seventh postoperative day, and all rats were sacrificed seven days after chemotherapy. Total adhesion scores in the induced standard defects were calculated by evaluating percentage of adhesion formation, as well as the severity and degree of the adhesions. The scores were compared among the groups. Results: Comparison of the severity, percentage, degree and total score of adhesions among the groups demonstrated that subjects in Group 1, where intraoperative alteplase irrigation was used, had fewer adhesion components (severity, percentage, degree) and a lower total adhesion score when compared to the other groups (p < 0.05). Adhesion components and the total adhesion score in Group IV, which did not receive chemotherapy, were found to be significantly lower when compared to Groups 11 and III (p < 0.05). Conclusion: Intraoperative Alteplase irrigation may reduce adhesion formation associated with intraperitoneal chemotherapy. Thus, intraperitoncal chemotherapeutic agents may be ensured to reach all peritoneal surfaces easily.Öğe The effect of varicocoelectomy on the relationship of oxidative stress in peripheral and internal spermatic vein with semen parameters(Wiley, 2016) Altintas, R.; Ediz, C.; Celik, H.; Camtosun, A.; Tasdemir, C.; Tanbek, K.; Tekin, S.The aim of this prospective controlled study was to investigate the levels of reactive oxygen species (ROS), including asymmetric dimethylarginine (ADMA), oxidative stress index (OSI) and total oxidant capacity (TOC), and antioxidants with total antioxidant capacity (TAC) in peripheral and internal spermatic veins blood, the relationship of these factors with sperm parameters in the infertile varicocoele patients, and the amelioration effect of varicocoelectomy on these outcomes. Thirty-one primary infertile varicocoele patients and 31 fertile control patients evaluated for determining the levels of ADMA, TOC, OSI, superoxide dismutase (SOD), glutathione (GSH), TAC, and semen analysis. The patients' preoperative SOD, GSH and TAC levels, which were significantly lower than the controls, significantly increased postoperatively. Although SOD and GSH were significantly higher in spermatic vein compared to median cubital vein, TAC was significantly higher in median cubital vein. ADMA, TOC and OSI were significantly higher in the patient group. TOC and OSI were significantly higher in spermatic vein compared to median cubital vein. Postoperative TOC, OSI and ADMA reduced to the control levels. Total antioxidant capacity in the peripheral circulation and oxidative stress index in the internal spermatic vein could give an idea about the possible improvement in sperm count acquired by varicocoelectomy.Öğe Evaluation of polymorphisms of the angiotensinogen M235T and angiotensin-converting enzyme gene insertion/deletion in patients craniocervical arterial dissection(Wiley-Blackwell, 2014) Celik, H.; Kaplan, Y.; Yesilada, E.; Gulbay, G.; Kamisli, O.; Ozcan, C.; Altinayar, S.[Abstract Not Available]Öğe The Relationship Between Cancer Patients' Supportive Care Needs and Their Attitudes Toward Complementary and Alternative Medicine(Wolters Kluwer Medknow Publications, 2024) Celik, H.; Aslan, H.Background:Cancer patients have high supportive care needs related to the nature of the disease and treatment methods. To meet these needs or reduce symptoms, patients can be expected to resort to alternative treatment methods. Aim:To examine the relationship between the supportive care needs of cancer patients and their attitudes toward complementary and alternative medicine (CAM). Methods:This was a cross-sectional study involving 289 cancer patients at the Oncology Hospital in east of Turkey. Short-Form Supportive Care Needs Survey Questionnaire (SCNS-SF 29) and Holistic Complementary and Alternative Medicine Questionnaire (HCAMQ) were standard instruments used for data collection. The association between supportive care needs and attitude toward CAM was determined. Results:The mean age of the study participants was 56.7 +/- 12.7 years. There were 180 females (62.3%) and 109 males (37.7%). The mean score of the SCNS-SF 29 of the study participant was 101.19 +/- 33.97. It was found that the patients' psychological needs were the highest, followed by health services and information, daily life, and sexuality needs, respectively. The mean score of the HCAMQ was 27.16 +/- 9.54. There was a weak, significant negative correlation between HCAM and psychological supportive care needs (r: -0.240, P: 0.003). However, there was no significant relationship between needs related to health services information, daily life sexuality, and attitudes toward CAM. Conclusions:Cancer patients have high supportive care requirements. Those with high psychological needs have a positive attitude toward HCAM. Incorporation of HCAM in the care of cancer patients may improve their quality of care.Öğe Steroid-induced bone necrosis of the femur and ocular hypertension in children with autoimmune hepatitis(Wiley-Blackwell, 2008) Ertekin, V.; Tuna, V.; Selimoglu, M. A.; Gullulu, G.; Celik, H.; Polat, P.[Abstract Not Available]
