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Öğe Anterior Prostatic Cyst Causing Acute Urinary Retansion in a Young Patient(Derman Medical Publ, 2016) Celik, Huseyin; Camtosun, Ahmet; Topcu, Ibrahim; Altintas, Ramazan; Tasdemir, CemalProstatic cysts are rare entities. Mostly, they originate from the posterior area of the prostate and asymptomatic. Anterior location of the prostatic cyst is rarer than posterior. The prostatic cyst in a 41 year-old man presenting with acute or nary retansion. Transurethral resection FUR) of the cyst was performed, which revealed a benign cyst lined with columnar epithelium and proliferative urothelial lining on histopathological evaluation. Prostatic cysts particularly in young men with obstructive lower urinary tract symptoms are rarely seen. Management of the prostatic cyst with TUR seems to be a minimally invasive approach with successful outcomes.Öğe Beneficial effects of nerolidol on thioacetamide-induced damage of the reproductive system in male rats(Allied Acad, 2016) Celik, Huseyin; Camtosun, Ahmet; Ciftci, Osman; Cetin, Asli; Aydin, Muhterem; Gurbuz, SukruIn this study, it was aimed to determinate beneficial effects of Nerolidol (NLR) against reproductive toxicity caused by Thioacetamide (TAA). Male, 3-4-months-old, rats (n=32) were divided into four groups. Group-1 was kept as control and given corn oil as carrier. Group-2 received TAA (200 mg/kg, intraperitoneal (i.p.), two times per week) for 3 weeks, in group-3; NRL was orally administered at the dose of 100 mg/kg per every other day by gavages, group-4; 200 mg/kg TAA and 100 mg/kg NRL were given. Thiobarbituric Acid Reactive Substances (TBARS) and reduced Glutathione (GSH) levels, Catalase (CAT), Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX), sperm parameters and reproductive organs weight were determined. TAA caused a significant rise in TBARS level and a significant reduce in GPX, CAT, SOD and GSH levels in the testicular tissues compared with the control group, while NLR led to significant reduce in lipid peroxidation via decreasing TBARS level and increasing the levels of GPX, CAT, SOD and GSH. Besides, sperm parameters significantly reduced, and pathologic testicular damage increased with TAA exposure. However, these effects of TAA on sperm parameters and histopathological changes were reversed by NLR treatment. In conclusion, our results demonstrate that the management of TAA induced the testicular damage and NLR prevented thioacetamide-induced testicular damage in rats.Öğe A Case of Cystitis Mimicking Bladder Tumor(Galenos Yayincilik, 2016) Camtosun, Ahmet; Celik, Huseyin; Altintas, Ramazan; Akpolat, NusretChronic cystitis is a usual inflammatory disease of the bladder in children. Patients typically show irritative voiding symptoms. In addition, bladder mass accumulation with the possibility of malignancy can rarely be observed. We present a 12-year-old male patient in whom radiological investigations showed a focal papillary lesion. In this paper, we aimed to discuss the management of chronic cystitis.Öğe A Case of Hydatid Cyst Mimicking Kidney Tumor(Aves, 2019) Camtosun, Ahmet; Celik, Huseyin; Yildiz, Ahmet; Altintas, Ramazan; Tasdemir, CemalA 45-year-old male patient presented with left flank pain that started a month ago. There was no history of fever or pyuria. Vital signs were normal. The rest of the systemic examination was unremarkable. There were no pathological findings on urinalysis or urine cytology. Ultrasonography revealed an 8x6.2x6 cm heterogeneous exophytic trending lesion at the lower pole of the left kidney. The lesion's walls were seen to be calcified in places, and the margin between the kidney and lesion was indistinct. It could not be differentiated by ultrasonography if the lesion is a complicated cyst or a mass. Magnetic resonance imaging scan of the upper abdomen also revealed a 9x7.5x7 cm cortical-parapelvic localized lesion at the lower pole of the left kidney, extending exophytically to the inferior. Given the possibility that the lesion is malignant, nephrectomy was planned. A laparoscopic approach was performed. Histopathological diagnosis was hydatid cyst. Enzyme-linked immunosorbent assay test for hydatid disease was negative. Albendazole 10 mg/kg twice a day was administered postoperatively for 3 weeks.Öğe Comparison of Cajal-like cells in pelvis and proximal ureter of kidney with and without hydronephrosis(Brazilian Soc Urol, 2015) Balikci, Omer; Turunc, Tahsin; Bal, Nebil; Celik, Huseyin; Ozkardes, HakanObjectives: To evaluate effects of Cajal-like cells on human renal pelvis and proximal ureter on peristalsis. Materials and Methods: 63 patients submitted to nephrectomy due to atrophic non- functional kidney associated with hydroureteronephrosis were included as study group and 30 cases with nephrectomy due to other reasons were included as control group. Samples from renal pelvis and proximal ureters were obtained and sections of 5 mu form paraffin blocks of these samples were prepared; layers of lamina propria and muscularis mucosa were examined by immune-histochemistry using CD117 in order to determine count and distribution of Cajal-like cells. Results: During immune-histochemical examinations of sections, obtained from renal pelvis and proximal ureter of hydronephrotic kidneys by CD117, Cajal-like cells number determined in lamina propria and muscularis propria was statistically significantly lower compared to control group (p<0.001). Distribution of Cajal-like cells in renal pelvis and proximal tubulus was similar under examination by light microscope, and also both groups were not different from each other regarding staining intensity of Cajal-like cells by c-kit. Conclusion: Significantly reduced number of Cajal-like cells in study group compared to control group, shows that these cells may have a key role in regulation of peristalsis at level of renal pelvis and proximal ureter in urinary system.Öğe Comparison of Percutaneous Nephrolithotomy Results in Pediatric Kidney Stone Disease in Patients Under the Age of 10 Years and in Patients Over the Age of 10 Years(Aves, 2016) Celik, Huseyin; Ediz, Caner; Camtosun, Ahmet; Altintas, Ramazan; Tasdemir, CemalObjective: Percutaneous nephrolithotomy (PNL) is a minimally invasive procedure that is safely performed for kidney stone surgery all over the world. In our clinic, PNL surgery was first performed in March 1998. In parallel with our increasing experience, PNL has been performed in pediatric cases. In our study, PNL operations performed in pediatric patients under the age of 10 years and in those over the age of 10 years were retrospectively investigated. Methods: Patients were between 0 and 16 years of age. They were divided into 2 groups according to age: 0-10 and 11-16 years. The PNL procedure was performed under general anesthesia with C-arm fluoroscopy in the prone position. Results: Between March 1998 and December 2014, a total of 208 pediatric urinary stone patients were operated on. The PNL procedure was performed in 210 renal units, 1 of which was performed bilaterally. In the <= 10-year-old patient group, 98 procedures (87.5%) were stone free, while clinically insignificant residual fragments (CIRFU) were found in 13 procedures (12.5%). In the > 10-year-old patient group, 88 procedures were stone free (89.79%), while clinically insignificant residual fragments were found in 9 procedures (10.2%). In the <= 10-year-old patient group, tubeless PNL was performed in 1 patient. In both groups combined, bleeding requiring transfusion occurred in just 1 case. A tract leak requiring a double J stent was detected in 1 patient in the <= 10-year-old patient group and in 2 patients in the other group. There was no other organ injury. Conclusion: PNL is a minimally invasive method and has become advantageous over open surgery because it offers higher security, particularly in experienced clinics, and procedures on pediatric patients can therefore be successfully performed.Öğe Comparison of the results of pediatric percutaneous nephrolithotomy with different sized instruments(Springer, 2017) Celik, Huseyin; Camtosun, Ahmet; Dede, Onur; Dagguli, Mansur; Altintas, Ramazan; Tasdemir, CemalWe aim to compare the outcomes, including the morbidity and success rates in children undergoing percutaneous nephrolithotomy (PCNL) using different sized devices. According to the size of instruments used during surgery, three different groups (ultra-mini-PCNL, mini-PCNL and adult size PCNL) were composed and the outcomes were compared between the groups. PCNL was applied to 225 renal units of 220 children, including 5 patients with bilateral kidney stones. Percutaneous nephrolithotomy was performed using adult instruments (24 F) in 82 renal units, using pediatric instruments (18 F) in 89 and using minimal-size instruments (9.5 F) in 50. One-hundred and twenty-four girls and 96 boys with a mean age of 8.33 (< 17) years were assessed. Stone-free rates were 78 % in group 1 (n = 39) using 9.5 F nephroscope, 75.8 % in group 2 (n = 69) using 18 F nephroscope and 71.4 % in group 3 (n = 60) using 24 F nephroscope. Time to access the collecting system, operative time, duration of nephrostomy and average postoperative hospital stay did not differ between the groups. However, mean hematocrit drop and stone burden were significantly lesser in ultra-mini-PCNL group. There was no significant difference in the complication rates between the groups, according to the modified Clavien classification system. As the important complication of PCNL, bleeding seems to be associated with diameter of dilatation, calibre of nephroscopes and stone burden. To reduce the certain complications, pediatric type of instruments is suitable but the use of adult instruments and techniques may achieve equal results.Öğe Does preoperative neutrophil-to-lymphocyte ratio have a value in predicting recurrence in bladder tumour after intravesical BCG treatment?(Scientific Publishers India, 2017) Camtosun, Ahmet; Celik, Huseyin; Altintas, Ramazan; Topcu, Ibrahim; Tasdemir, CemalThe purpose of this study was to evaluate the prognostic value of the ratio of preoperative neutrophil to lymphocyte after intravesical BCG treatment in non-muscle invasive bladder cancer (NMIBC). The data of 89 patients, operated for urothelial carcinoma and treated with BCG after the diagnosis of NMIBC between 2007 and 2014, were reviewed retrospectively. Preoperative complete blood counts and first cystoscopic examination findings of the patients were examined. Median follow-up was 28.7 months. Tumour recurrence was detected in 33 patients (Group 2) of 89 patients. There was no tumour recurrence in 56 patients (Group 1). Neutrophil/lymphocyte ratio, MPV and CIS incidence were significantly increased in Group 2. This study showed that, preoperative high neutrophil/lymphocyte ratio, MPV and CIS occurrence can be used as independent criteria to predict tumour recurrence after intravesical BCG treatment in NMIBC.Öğe Evaluation of Prostatic Artery Embolization Efficiency in Benign Prostatic Hyperplasia Patients with High Comorbidity(Galenos Yayincilik, 2018) Yildirim, Ismail Okan; Duman, Enes; Firat, Ali; Celik, Huseyin; Sarac, KayaObjective: The purpose of this study was to evaluate efficacy outcomes following prostate artery embolization (PAE) for the treatment of benign prostatic hyperplasia (BPH) patients with high comorbidity. Materials and Methods: This retrospective study included 22 patients treated with PAE from May 2015 to June 2017. Patients with Charlson comorbidity index >= 2, International Prostate Symptom Score (IPSS) >12, prostate specific antigen (PSA) levels <4 ng/mL or between 4 and 10 ng/mL with negative prostate biopsy and total prostate volume (TPV) >90 cm(3) were included. Total PSA, maximum flow rate (Q(max)), TPV, IPSS, post-voiding residual (PVR) values were recorded in all patients in the urology clinic before PAE and at 3 and 6 months after PAE. Results: The average patient age was 73.86 +/- 6.25 years and operative time was 80 minutes (range, 60-120 min). Pre-PAE and 6-month post-PAE values were: IPSS: 25.18 +/- 6.75 an d 11.27 +/- 3.29 (p<0.05), Q(max): 8.31 +/- 3.12 and 17.22 +/- 3.23 (p<0.05), PVR: 87.9 +/- 19.25 and 25.86 +/- 7.72 (p<0.05), TPV: 134.45 +/- 57.56 and 86 +/- 15.4 (p<0.05), and PSA: 3.89 +/- 1.26 and 2.11 +/- 1.06 (p<0.05). Embolization was performed unilaterally due to atherosclerosis and strictures in the internal iliac artery branches in 2 patients. After the procedure, 2 patients experienced transient hematuria which did not require bladder irrigation, 1 patient had acute urinary retention due to dysuria, and 1 patient had transient hematospermia. Conclusion: PAE may be an alternative treatment method in BPH patients with high comorbidity.Öğe Evaluation of prostatic artery embolization efficiency in benign prostatic hyperplasia patients withhigh comorbidity(Galenos yayıncılık, erkan mor, molla guranı cad 21-1, fındıkzade, ıstanbul 34093, turkey, 2018) Yildirim, Ismail Okan; Duman, Enes; Firat, Ali; Celik, Huseyin; Sarac, KayaObjective: The purpose of this study was to evaluate efficacy outcomes following prostate artery embolization (PAE) for the treatment of benign prostatic hyperplasia (BPH) patients with high comorbidity. Materials and Methods: This retrospective study included 22 patients treated with PAE from May 2015 to June 2017. Patients with Charlson comorbidity index >= 2, International Prostate Symptom Score (IPSS) >12, prostate specific antigen (PSA) levels <4 ng/mL or between 4 and 10 ng/mL with negative prostate biopsy and total prostate volume (TPV) >90 cm(3) were included. Total PSA, maximum flow rate (Q(max)), TPV, IPSS, post-voiding residual (PVR) values were recorded in all patients in the urology clinic before PAE and at 3 and 6 months after PAE. Results: The average patient age was 73.86 +/- 6.25 years and operative time was 80 minutes (range, 60-120 min). Pre-PAE and 6-month post-PAE values were: IPSS: 25.18 +/- 6.75 an d 11.27 +/- 3.29 (p<0.05), Q(max): 8.31 +/- 3.12 and 17.22 +/- 3.23 (p<0.05), PVR: 87.9 +/- 19.25 and 25.86 +/- 7.72 (p<0.05), TPV: 134.45 +/- 57.56 and 86 +/- 15.4 (p<0.05), and PSA: 3.89 +/- 1.26 and 2.11 +/- 1.06 (p<0.05). Embolization was performed unilaterally due to atherosclerosis and strictures in the internal iliac artery branches in 2 patients. After the procedure, 2 patients experienced transient hematuria which did not require bladder irrigation, 1 patient had acute urinary retention due to dysuria, and 1 patient had transient hematospermia. Conclusion: PAE may be an alternative treatment method in BPH patients with high comorbidity.Öğe Laparoscopic Transperitoneoscopic Nephroureterectomy in a Patient with Situs Inversus Totalis(Springer India, 2015) Gokcen, Kaan; Celik, Huseyin; Kobaner, Murat; Karazindiyanoglu, SinanThis article discusses the case of a 78-year-old female with painless gross hematuria. Chest X-rays showed dextrocardia with situs inversus, and whole-body computed tomography scanning showed a renal mass in the right renal pelvis, no evidence of metastasis, and mirror-image organs with left-to-right transposition, which resulted in a diagnosis of situs inversus totalis (SIT). A laparoscopic transperitoneoscopic right nephroureterectomy was scheduled. To our knowledge, our case is the second case of laparoscopic nephroureterectomy in renal pelvic urothelial carcinoma with SIT to be presented, but it is the first case of laparoscopic transperitoneoscopic nephroureterectomy. Laparoscopic transperitoneoscopic nephroureterectomy was successfully performed in a renal pelvic urothelial carcinoma patient with SIT with a correct description of renal vascularity and abdominal anatomy.Öğe Percutaneous nephrolithotomy in children with pediatric and adult-sized instruments(Elsevier Sci Ltd, 2016) Celik, Huseyin; Camtosun, Ahmet; Altintas, Ramazan; Tasdemir, CemalObjective Pediatric stone disease is a significant health issue which has increased in incidence because of lifestyle changes, dietary habits, and obesity. The incidence of urolithiasis among pediatric age groups varies according to region and is high in Turkey. The management of stone disease in children has improved dramatically over the last two decades. The high success rate of percutaneous nephrolithotomy (PNL) have led modern researchers to suggest that it be used as a first-line treatment of kidney stones greater than 2 cm in size. This study compared the outcomes, including morbidity and success rates, of different groups of pediatric patients who underwent PNL via pediatric-and adult-sized instruments. Methods Percutaneous nephrolithotomy was performed in 194 children in a clinical setting between the years 2000 and 2015. Patients were categorized into 2 groups (group 1: pediatric-sized devices used, n = 90 [46.4%]; group 2: adult-sized devices used, n = 104 [53.6%]). The children in group 2 were further divided into subgroups: a 24 F nephroscope was used for group 2a (n=84 [43.3%]) and a 26 F nephroscope was used for group 2b (n = 20 [10.3%]) (Figure). Results For this study, a total of 194 pediatric patients (99 boys and 95 girls ranging from 8 months to 17 years of age, with a mean age of 9.43 years) underwent PNL for the removal of kidney stones in a clinical setting. Between the examined groups, there were no significant differences in patient height or weight, stone site or localization, pre-and post-operative creatinine levels, duration of nephrostomy, or hospitalization time. There was also no significant variation in minor complications such as fever or urinary infection. However, the stone burden was notably smaller in the group wherein pediatric-sized nephroscopes were used. Additionally, the incidence of hemorrhage was markedly lower in groups where a 17 F nephroscope was used than in groups where treatment was administered via 24 and 26 F nephroscopes. Conclusions Stone disease is considered to be relatively rare in childhood, but recent studies have indicated that it presents a considerable health problem. According to some researchers, a decrease in instrument size has not meaningfully reduced complication rates. In contrast, some studies have reported that the use of smaller sized nephroscopes may reduce rates of morbidity and mortality. In this study, success rates of PNL were similar across all groups, regardless of nephroscope size. However, the use of a 17 F nephroscope significantly decreased the rate of hematocrit level reduction (p < 0.001). While instrument size does not affect the success of PNL, smaller instruments can be used to reduce various complications such as bleeding.Öğe A Rare Neoplasm of the Prostate: Small Lymphocytic Lymphoma(Galenos Yayincilik, 2014) Celik, Huseyin; Cimen, Serhan; Akpolat, NusretProstate lymphoma is a rare condition, it accounts for 0.09% of all prostate malignancies. As other prostate diseases, prostate lymphoma occurs in the same age group and it is difficult to distinguish clinically. We report a case of 63 year-old male with acute urinary retention twice and normal serum level of prostate specific antigen. We performed transurethral resection (TUR). In the microscopic examination of the TUR material a diffuse lymphocytic infiltration which were strongly positive for CD20 and CD5 and negative for CD3.Öğe Renal Primitive Neuroectodermal Tumor(Galenos Yayincilik, 2017) Celik, Huseyin; Camtosun, Ahmet; Dursun, Ibrahim; Akpolat, Nusret; Yildirim, Ismail OkanRenal primitive neuroectodermal tumor ( PNET) is a rare entity and highly malignant neoplasm. It generally occurs in young adults and children. We report a case of 19-year-old female with the complaint of left flank pain. Ultrasonography showed a tumor of the left kidney. A big left inhomogeneous renal mass of 10x8 cm with areas of necrosis was observed on computed tomography. The patient underwent radical nephrectomy with lymphadenectomy. Immunohistochemical stains were positive for CD99 and FL-1. Immunohistochemical and microscopic results were compatible with PNET. Furthermore, the patient received eight cycles of chemotherapy, and was still alive without metastases at 6-month followup. Renal PNET is a rare and poor prognosis tumor. It is sometimes difficult to discriminate between PNET and Ewing's sarcoma. Renal PNET must be included in the differential diagnosis of renal tumors particularly in young adults and children. With this case report it aimed to create awareness about PNET.
