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    Clinical, pathological and endocrinological evaluation of patients with microscopic transsphenoidal pituitary surgery
    (2021) Ozcelik, Serhat; Gokkaya, Naile; Tiryaki, Mehmet; Aydogdu, Evren; Celik, Mehmet; Yavuzer, Dilek; Aydin Tezcan, Kadriye
    Aim: Detailed evaluation of patients in preoperative stage is an important factor that reduces morbidity and mortality as well as the operation itself. In our study, we aimed to examine clinically, pathologically and endocrinologically, the patients who were decided to undergo transsphenoidal surgery, in light of the literature.Materials and Methods: In this retrospective observational study, preoperative and pathological data of consecutive pituitary adenoma patients who applied to our department from January 2019 to June 2020 and underwent transsphenoidal surgery with microscopic methods, were examined.Results: The study included a total of 31 patients. Distribution of patients in relation to pathological diagnoses was as follows: Functional pituitary adenoma (n: 15), non-functional adenoma (n: 11), apoplexy (n: 2), carcinoma metastasis (n: 2) and craniopharyngioma (n: 1). No statistically significant difference was found between functional and non-functional adenomas, in terms of tumor size, cavernous sinus invasion, Ki-67 index and p53 staining pattern (p> 0.05) whereas presence of suprasellar extension and visual field defect were significantly more in non-functional adenomas (p = 0.015, p = 0.045, respectively).Conclusion: Highly invasive character was detected in both functional and non-functional pituitary Ki-67 indexes were low in the study population, increased p53 expression was noticeable. We can state that the Ki-67 index may not be directly proportional to the invasive behavior of the disease.
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    Comparison of Tp-e interval, QTc interval and Tp-e/QTc ratios between non-diabetic and prediabetic population
    (2020) Celik, Mehmet; Ardahanli, Isa
    Aim: Increased blood glucose concentration and cardiac autonomic nerve dysfunction are associated with an increased risk of malignant ventricular arrhythmia. Tp-e interval, Tp-e/QT, and Tp-e/QTc are novel parameters used to assess ventricular arrhythmogenicity. This study aimed to compare these parameters with the healthy control group in prediabetics. Materials and Methods: The ECGs of 58 prediabetic patients (29 male, 59.74 ±13.25 years) were examined and matched with the ECGs of 59 healthy controls (28 male, 61.75 ± 12.66 years) that were matched with gender, age and body mass index. From the 12-lead ECG Tp-e and QT intervals were measured and by Bazett's formula QTc was calculated. Tp-e/QT and Tp-e/QTc proportions were also determined. Results: In prediabetic patients, the mean Tp-e interval was significantly longer than the control group (79.07 ± 8.17 vs 72.03 ± 9.77 ms, respectively; p 0.001). Also in prediabetic, Tp-e/QT and Tp-e/QTc were significantly higher than the controls (respectively 0.21 ± 0.25 vs 0.19 ± 0.03 and 0.19 ± 0.02 vs 0.17 ± 0.02; p 0.001). Other ECG parameters were similar in both groups. HbA1c levels and glucose levels were positively correlated with Tp-e / QT and Tp-e / QTc.Conclusion: Prediabetes increases the risk of ventricular arrhythmogenesis by increasing the transmural dispersion of repolarization. The addition of Tp-e interval and TP-e / QT measurements to the routine ECG evaluation of prediabetic patients can be used to predict arrhythmia risk.