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Öğe Acardiacus acephalus type twin pregnancy(Taylor & Francis Inc, 2011) Celik, O.; Karaer, A.; Cagiran, F. T.; Kaplan, S.[Abstract Not Available]Öğe Adrenomedullin: Possible predictor of insulin resistance in women with polycystic ovary syndrome(Springer, 2012) Sahin, I.; Celik, O.; Celik, N.; Keskin, L.; Dogru, A.; Dogru, I.; Yurekli, M.The aim of the study was to investigate adrenomedullin (ADM) levels and its relation with insulin resistance in women with polycystic ovary syndrome (PCOS). Twenty-nine women with PCOS and 29 age- and body mass index (BMI)-matched control subjects were included in the study. PCOS was defined according to criteria by the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)-sponsored PCOS consensus workshop group. A full clinical and biochemical examination including basal hormones and metabolic profile was performed. Insulin resistance was calculated by using the homeostasis model assessment of insulin resistance index (HOMA-IR). Plasma ADM levels were measured by high performance liquid chromatographic (HPLC) method. Plasma ADM, fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS than the control group. ADM levels were positively correlated with insulin levels and HOMA-IR index. The best cut-off value of ADM levels to identify the presence of insulin resistance (HOMA-IR >= 2.7) was 30.44 ng/ml. Calculated odds ratio of insulin resistance by using logistic regression analysis, as predicted by ADM, was 0.15 (95% confidence interval, 0.037-0.628; p=0.009). In multiple regression analysis, ADM level was an independent predictor of HOMA-IR index. Our finding indicated that ADM levels increased in women with PCOS in accordance with HOMA-IR. ADM could be a significant independent determinant of insulin resistance in women with PCOS. (J. Endocrinol. Invest. 35: 553-556, 2012) (C) 2012, Editrice KurtisÖğe Adropin: a key component and potential gatekeeper of metabolic disturbances in policystic ovarian syndrome(7847050 Canada Inc, 2014) Yildirim, B.; Celik, O.; Aydin, S.Purpose: The aim of the current study was to evaluate potential relationships between serum adropin levels and metabolic parameters in polycystic ovary syndrome (PCOS). Materials and Methods: Twenty women with PCOS and 20 healthy, age and body mass index (BMI) matched controls were included in the study. All subjects underwent venous blood drawing on the early follicular phase after an overnight fasting. Serum adropin levels were measured with enzyme immunosorbent assay (ETA). The relationships between serum adropin levels and metabolic parameters were also assessed. Results: Serum adropin levels were found to be significantly lower in women with PCOS when compared to control group (p < 0.001). Serum adropin level was correlated negatively with fasting serum insulin levels, homeostasis model of assessment - insulin resistance (HOMA-IR) and serum lipid markers including cholesterol, very low-density lipoprotein, and triglycerides (TG) in PCOS patients (p < 0.05). Conclusion: The findings of current study suggest that women with PCOS have low serum adropin levels that may contribute to the underlying pathogenesis of metabolic disturbances in PCOS.Öğe An appraisal on serum preptin levels in polycystic ovary syndrome(Oxford Univ Press, 2010) Celik, O.; Hascalik, S.; Celik, N.; Sahin, I.; Aydin, S.[Abstract Not Available]Öğe Chronic pain and rat brain: Microstructural cerebral changes revealed by diffusion-weighted magnetic resonance imaging(Elsevier Science Bv, 2006) Hascalik, M.; Karakas, H. M.; Celik, O.; Firat, A. K.; Hascalik, S.[Abstract Not Available]Öğe Disulfiram, as a candidate NF-?B and proteasome inhibitor, prevents endometriotic implant growing in a rat model of endometriosis(Verduci Publisher, 2016) Celik, O.; Ersahin, A.; Acet, M.; Celik, N.; Baykus, Y.; Deniz, R.; Ozerol, E.OBJECTIVE: Disulfiram (DSF) exerts its therapeutic effects through oxidative, proteasome, and nuclear factor kappa beta (NF-kappa B) pathways. The study was planned to test the impact of DSF on growing of endometriotic implants in rats with experimentally induced endometriosis. PATIENTS AND METHODS: Thirty rats were labeled as the control (n = 8), sham (n = 6), GnRH-agonist (n = 8) and the DSF (n = 8) groups. The rats in the group 3 exposed to single dose leuprolide acetate. The rats in group 4 were treated with DSF for 21 days. The serum activity of oxidant and antioxidant markers, total oxidant status (TOS), total antioxidant status (TAS), interleukin-1 beta, and tumor necrosis factora (TNF-alpha) were determined. Implants were processed for NF-kappa B, PCNA, and CD34 immunostaining. RESULTS: The serum concentration of malondialdehyde in the DSF group was significantly higher than those in other groups. The concentration of TAS, TNF-alpha, and interleukin-1 beta in the DSF group considerably decreased compared to control group. Following treatment with DSF while the percentage of Grade 1 and 2 implants increased the percentage of Grade 3 and 4 implants decreased. The implants disappeared totally in two cases in the DSF group and one case in the GnRH-agonist group. The mean H-Scores of implant NF-kappa B and PCNA in DSF treated animals were found to significantly lower than those of the control group. CONCLUSIONS: By decreasing NF-kappa B expression, angiogenesis, and cell proliferation DSF prevents the growth of endometriotic implants.Öğe Follicular fluid adenosine deamines (ADA), superoxide dismutase and nitric oxide levels in GnRH agonist and antagonist cycles(Oxford Univ Press, 2012) Celik, E.; Celik, O.; Kumbak, B.; Yilmaz, E.; Turkcuoglu, I.; Simsek, Y.; Karaer, A.[Abstract Not Available]Öğe Glutathione, malondialdehyde and nitric oxide levels in endometrium of patients with unexplained infertility during the implantation window(Oxford Univ Press, 2012) Karaer, A.; Celik, O.; Karabulut, A. Bay; Celik, E.; Kiran, T. R.; Simsek, O. Y.; Yilmaz, E.[Abstract Not Available]Öğe The inhibitory effect of Resveratrol on experimental endometriosis via nuclear factor kappa B-independent pathway(Oxford Univ Press, 2012) Simsek, Y.; Celik, O.; Cigremis, Y.; Akgoz, M.; Ozerol, E.; Tanbek, K.; Turhan, U.[Abstract Not Available]Öğe Maternal serum and cord blood preptin levels in gestational diabetes mellitus(Nature Publishing Group, 2011) Aslan, M.; Celik, O.; Karsavuran, N.; Celik, N.; Dogan, D. G.; Botan, E.; Kafkasli, A.Objective: To assess preptin concentrations in pregnant women with and without gestational diabetes mellitus (GDM) and in the cord blood of their fetuses. Study Design: In all, 31 pregnant women with GDM and 31 gestational age-matched healthy pregnant subjects participated. Maternal serum and cord blood preptin levels were measured with ELISA. The relationships between maternal serum and cord blood preptin levels, anthropometric and metabolic parameters were also assessed. Result: Maternal serum and cord blood preptin levels were found higher in patients with GDM compared with control pregnant women. Preptin concentration in maternal serum was positively correlated with maternal age, fasting insulin levels, 1-h blood glucose after glucose load and cord preptin concentrations at birth. However, relationships between maternal and/or cord serum preptin and fetal growth parameters at birth were not detected. Conclusion: Our results indicate that preptin concentrations increase in maternal serum of women with GDM. Preptin levels may provide a novel approach to identify women with GDM. Journal of Perinatology (2011) 31, 350-355; doi:10.1038/jp.2010.125; published online 16 December 2010Öğe Plasma urocortin levels in women undergoing long agonist and antagonist protocols for IVF(Oxford Univ Press, 2011) Celik, N.; Celik, O.; Aktan, E.; Ozerol, E.; Celik, E.; Bozkurt, K.; Paran, H.[Abstract Not Available]Öğe Prevalence and predictors of gestational diabetes mellitus: a nationwide multicentre prospective study(Wiley, 2019) Aydin, H.; Celik, O.; Yazici, D.; Altunok, C.; Tarcin, O.; Deyneli, O.; Sancak, S.Aim Prevalence rates of gestational diabetes mellitus (GDM) show considerable variation among different countries and regions of the world. The primary aim of this study was to determine the nationwide prevalence and predictors of GDM in Turkey. Methods We conducted prospective nationwide screening among pregnant women. Between August 2016 and November 2017, a total of 2643 pregnant women from 51 centres in 12 different regions were enrolled. A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of GDM. Clinical and biochemical data were obtained using electronic database software. Results The national prevalence of GDM was found to be 16.2% [95% confidence intervals (CI) 15.0% to 17.4%] without a significant difference between urban and rural regions. Women with GDM were older (mean age: 32 +/- 5 vs. 28 +/- 5 years, P < 0.001) and heavier (mean BMI: 27.2 +/- 5.1 vs. 24.7 +/- 4.7 kg/m(2), P < 0.001) than their counterparts without GDM. The prevalence of GDM tended to increase with age (< 25 years, 6.9%; 26-35 years, 15.6%; and 36-45 years, 32.7%; P < 0.001). Maternal age, maternal BMI, history of previous GDM and family history of diabetes mellitus were independent predictors of developing GDM (P < 0.05 for all). Low-risk women (age < 25 years, BMI < 25 kg/m(2), no family history of diabetes) comprised 10.7% of the total population and the prevalence of GDM in these women was 4.5% (95% CI 2.4% to 7.8%). Conclusion The results of this nationwide study indicate that GDM is very common, affecting one in seven pregnancies in Turkey. Implementation of international guidelines on screening and management of this public health problem is required.Öğe Resveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidation(Wolters Kluwer Medknow Publications, 2014) Yavuz, Simsek; Aydin, Nasuhi E.; Celik, O.; Yilmaz, E.; Ozerol, E.; Tanbek, K.Background and Aims: The purpose of this study was to investigate the potential therapeutic efficiency of resveratrol in the treatment of experimental endometriosis in rats. Settings and Design: Experimental study was carried out in a University hospital. Materials and Methods: Endometriosis was surgically induced in 24 female rats. Four weeks after this procedure, the viability and dimensions of the endometriosis foci were recorded. Rats were then randomly divided into three groups: (1) Control group (n = 8); (2) low dose (10 mg/kg) resveratrol group (n = 8); (3) high dose (100 mg/kg) resveratrol group (n = 8). At the end of the 7-day treatment, blood samples were taken and laparotomy was performed. The endometrial implants were processed for biochemical, histological and immunohistochemical studies. Statistical Analysis Used: The Kruskal-Wallis H test and one-way ANOVA test were used. Results: Resveratrol-treated rats showed significantly reduced endometriotic implant volumes (P = 0.004). After treatment, a significant and dose-dependent increase in activities of superoxide dismutase and glutathione peroxidase in serum and tissue of the rats in Group 2 and Group 3 was detected. Similarly, serum and tissue malonyl dialdehyde levels and tissue catalase levels were significantly higher in Group 3 than that of control animals. Histological scores and proliferating cell nuclear antigen expression levels were also significantly reduced in Group 2 and Group 3 than that of control group. Conclusion: In a rat endometriosis model, resveratrol showed potential ameliorative effects on endometriotic implants probably due to its potent antioxidative properties.Öğe Role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility(Elsevier, 2014) Tanrikut, E.; Karaer, A.; Celik, O.; Celik, E.; Otlu, B.; Yilmaz, E.; Ozgul, O.Objective: To determine the role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility. Study design: Thirty-three women with unexplained infertility and 32 fertile women were recruited. Endometrial biopsies were collected during the putative window of implantation (cycle days 20-24). The concentrations of cadmium, lead, mercury and arsenic were measured in endometrial biopsy specimens using atomic absorption spectrometry. Results: Cadmium was detected in 91% (30/33) of women with unexplained infertility, compared with 34% (11/32) of fertile women. The median endometrial cadmium concentration was 19.58 (interquartile range 1.46-30.23) mu g/l in women with unexplained infertility, compared with 0.00 (interquartile range 0.00-0.40) mu g/l in fertile women. Lead was detected in 15% (5/33) of women with unexplained infertility and 3% (1/32) of fertile women. Mercury and arsenic were not detected in any endometrial samples from either group. Conclusion: A significant difference in endometrial cadmium concentration was found between women with unexplained infertility and fertile women. This suggests that cadmium may be a contributing factor in the aetiology of unexplained infertility. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe Spectral changes in electrical activity of pylorus due to L-NAME induced hypertrophic pyloric stenosis(Comenius Univ, 2011) Aslan, M.; Celik, O.; Dogan, D. G.; Tagluk, M. E.; Ulas, M.; Aydin, E.Objectives: To investigate the relation between hypertrophic pyloric stenosis (HPS) and the changes in the myoelectrical activity of the pyloric and gastric areas. Methods: Three pregnant females, at 14 days of gestation two of which were named as D14n (NOS inhibitor group) and one was named as D14c (control). From the beginning of the study until the end of gestation, rats in D14n group received nitric oxide synthase inhibitor L-NAME for administrating their pups, and the rat in D14c group was drinking water for 21 days. The pups of each group underwent laparotomy at 42 days of their life and myoelectrical signals of their pyloric and gastric regions were recorded via bipolar electrodes and then evaluated through signal processing. Results: Signal analysis showed that HPS induced pyloric segment reveals a suppressed spectral component that was detected in normal pyloric segment. The HPS induced pyloric segment also revealed higher power/min and +/- SD compared to that of normal and gastric areas. In the pyloric segment, while the number of interstitial cells of Cajal (ICC) was lesser, the number of smooth muscle cells was higher than in the pyloric segment of controls. Conclusions: The spectral differentials depend on the type, population and condition of locally specialized muscular mechanism which can be affected from HPS. The HPS also has a relation to specific cells, such as ICC that generates NO, provoke the spontaneous pacemakers and biological slow waves (Tab. 1, Fig. 1, Ref. 19). Full Text in free PDF www.bmj.sk.Öğe Spectroscopy analysis of cervical carcinoma originated from endometrial carcinoma(Informa Healthcare, 2012) Celik, O.; Yilmaz, E.; Boz, M.; Hascalik, S.; Karakas, H. M.; Aydin, N. E.[Abstract Not Available]Öğe Spontaneous resolution of fetal dural sinus thrombosis following term delivery of a live infant(Wiley-Blackwell, 2012) Simsek, Y.; Oztanir, N.; Sigirci, A.; Celik, E.; Yilmaz, E.; Celik, O.; Onal, C.[Abstract Not Available]Öğe Therapeutic efficiency of atosiban, an oxytocin receptor antagonist in the treatment of experimental endometriosis(Oxford Univ Press, 2011) Simsek, Y.; Celik, O.; Yilmaz, E.; Karaer, A.; Koc, O.; Aydin, N. E.[Abstract Not Available]Öğe XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear(Verduci Publisher, 2012) Yilmaz, E.; Celik, O.; Celik, E.; Turkcuoglu, I.; Simsek, Y.; Karaer, A.; Otlu, B.AIM: The purpose of the present study was to identify the role of abnormalities in DNA repair pathways by measuring the XPD and XRCC1 gene polymorphisms. MATERIALS AND METHODS: Thirty-five patients with abnormal cervical cytology (study group) and 10 women with normal cytology (control group) were included in the study. The polymorphisms of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XPD Lys751Gln genes were investigated from the blood samples. RESULTS: There was no statistically significant difference in allele frequencies of XPD gene among the groups (p = 0.097), while XRCC1R399Q gene polymorphism was strikingly more frequent in the study group than that of control cases (p = 0.029). The prevalence of XRCC1R194W gene polymorphism on the other hand, was similar between the groups (p = 0.579). CONCLUSIONS: Patients with abnormal and normal cervical cytology have similar XPD gene polymorphism. However, the frequency of gene polymorphism in XRCC1 Arg 399 Gln codon was significantly higher in abnormal cervical cytology group.
