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Öğe Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients(Folia Parasitologica, 2015) Celik, Tuncay; Kartalci, Sukru; Aytas, Ozgur; Akarsu, Gulay Aral; Gozukara, Harika; Unal, SuheylaThe aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15x higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients.Öğe Co-infection of cyclospora cayetanensis and cryptosporidium parvum in an immunocompetent patient with urticaria without diarrhea: case report(Int Scientific Literature, Inc, 2008) Celik, Tuncay; Karincaoglu, Yelda; Karaman, Ulku; Daldal, Nilgun UlfetBackground: Cyclospora cayetanensis and Cryptosporidium parvum, a coccidian parasites and induce a diarrhea illness of the small intestinal, are the causative agents, a transmitted via contaminated water or food. We aimed to examine the stool of a patient being urticaria without diarrhea. Case Report: In 2007 a six-year-old boy living in Elbistan, non-tropical region in Turkey, was transferred by his parents to the Dermatology policlinic of Inonu University from Elbistan state hospital due to only prolonged pruritic swellings on his body. The patient showed no symptoms such as stomachache, fever, nausea and vomiting. His fecal sample was mild with no trace of mucosa or blood. It was reported that The patient didn't have any allergies such as drug. Laboratory studies on admission were notable, with PLT of 434 units/L, EO of 4.4 units/L, ASO of 148 units/L, CRP of 3 units/L, AST of 25 units/L, ALT of 12 units/L, and Total IgE of 75 IU/mL. Otology serum and Prick tests revealed negative results. Moreover the patient was found to have no allergic reactions to any food, tree, grass, mold, and animals. The organisms were identifi ed as C. cayetanensis and C. parvum in the stool sample. After treated with Metronidazole and Azithromycin. Fecal specimen were examined. As a result no sign of the parasites were observed and urticaria complaints disappeared. Conclusions: This report is the first case that have seen co-infection of cyclosporiasis and cryptosporidiasis in an immunocompetent patient who have urticaria complaints and without diarrhea. It is believed that these parasites are likely to cause allergic reactions among patients who have constant urticaria complaints, can not develop immunological reaction to various allergens, and have high total IgE antibodies.Öğe Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients(Int Scientific Information, Inc, 2009) Celik, Tuncay; Akarsu, Guelay Aral; Gungor, Cigdem; Colak, Cemil; Ormeci, NecatiBackground: Cystic echinococcosis (CE), caused by the metacestode stage of Echinococcus granulosus, is one of the most important zoonoses worldwide. Long post-treatment follow-up is required because of possible relapse. The objective of this study was to determine the values of different antigenic fractions of sheep hydatid cyst fluid in the follow-up of CE patients after treatment. Material/Methods: After gradient gel electrophoresis of sheep hydatid cyst fluid, 45 post-treatment (1 month - 16 years) serum samples of CE patients treated with PAIR (puncture, aspirations, injection, and respiration) and five post-treatment (1 month) sera of operated CE patients were studied using Western blot. Twenty healthy individuals and five patients infected with other helminths served as controls. Results: Antigens with molecular weights of 6.5-8, 14, 20, 29, 45, 50, 66, 116-120, 205, and 215 kDa were identified. The bands detected at the highest frequency were 29 kDa (10.4%), 45 kDa (17.2%), and 66 kDa (12.8%). Sera of the 20 healthy controls recognized no specific bands. All of the sera of the five patients with other parasitic diseases recognized one or more hydatid cyst fluid antigens. There was a statistically significant difference between the time after treatment and band weights (p<0.0001). Conclusions: The protein bands of 29 and 205-215 kDa may be valuable in the follow-up of cystic echinococcosis patients as they disappear one year and six months, respectively, after therapy.Öğe Glutathione and malondialdehyde levels in patients with hydatid cyst(Saudi Med J, 2008) Atambay, Metin; Karaman, Ulku; Kiran, Tugba P.; Colak, Cemil; Karabulut, Aysun B.; Celik, Tuncay; Daldal, NilgunObjective: To investigate the levels of glutathione (GSH), and malondialdehide (MDA) in the sera of patients diagnosed with cyst hydatid. Methods: Forty-six hydatid cyst patients who were indirect hemaglutination (IHA) and indirect fluorescence antibody (IFA) test positive constituted our study group in 2007. Patients diagnosed with hydatid cyst in the Inonu University School of Medicine, Department of Parasitology were re-called for the study. Forty healthy subjects who were negative for hydatid cyst by IRA and IFA methods, and who did not have any parasites on stool inspection formed the control group. The MDA level was analyzed in the sera by Uchiyama and Mihara method. The GSH activity was measured by the Ellman method. Results: The GSH level was 11.31 +/- 3.80 mu mol/L and the MDA level was 67.94 +/- 106.70 mu mol/L in the study group, while they were 24.95 +/- 6.55 mu mol/L and 26.52 +/- 19.42 mu mol/L in the control group. Conclusion: An increase in MDA levels and a decrease in GSH activity in patients with hydatid cyst was observed.Öğe A Heart Transplant Recipient Lost Due to Pneumocystis jiroveci Pneumonia Under Trimethoprim-Sulfamethoxazole Prophylaxis: Case Report(Baskent Univ, 2010) Celik, Tuncay; Gedik, Ender; Kayabas, Uner; Bayindir, Yasar; Gulbas, Gazi; Firat, Ahmet Kemal; Togal, TurkanInfections in solid-organ transplant recipients are the most important causes of morbidity and mortality. A primary goal in organ transplant is the prevention or effective treatment of infection, which is the most-common life-threatening complication of long-term immunosuppressive therapy. A 21-year-old woman who underwent heart transplant 3 years previous owing to dilated cardiomyopathy was referred to our hospital with symptoms of high fever and cough. The patient's history revealed that she had received a trimethoprim-sulfamethoxazole double-strength tablet each day for prophylactic purposes. On chest radiograph, pneumonia was detected, and in broncho-alveolar lavage sample, Pneumocystis jiroveci cysts were found. After diagnosing P. jiroveci pneumonia, trimethoprim-sulfamethoxazole was initiated at 20 mg/kg/d including intravenous trimethoprim in divided dosages every 6 hours. On the sixth day of therapy, she died in intensive care unit. In solid-organ transplant recipients, although antipneumocystis prophylaxis is recommended within the first 6 to 12 months after transplant, lifelong prophylaxis is also used in several settings. In addition, the physician should keep in mind that P. jiroveci pneumonia may develop in solid organ recipients, despite trimethoprim-sulfamethoxazole prophylaxis.Öğe Is there a relationship between Toxoplasma gondii infection and idiopathic Parkinson's disease?(Informa Healthcare, 2010) Celik, Tuncay; Kamisli, Ozden; Babur, Cahit; Cevik, Muhammer Ozgur; Oztuna, Derya; Altinayar, SibelIdiopathic Parkinson's disease defines a group of Parkinson's disease (PD) of which the aetiology is unknown but an underlying brain disease is suspected. We selected patients of this subgroup of PD and investigated the seropositivity rate for anti-Toxoplasma IgG antibody by Sabin-Feldman dye test (SFDT). By measuring seropositivity in PD patients, we searched for a probable relationship between Toxoplasma gondii infection and idiopathic PD incidence. Fifty patients diagnosed with idiopathic PD and 50 healthy volunteers were included in the study. Blood samples were taken from all 100 participants and anti-T. gondii antibody titres were investigated using SFDT. Anti-T. gondii antibodies were detected at a titre of >= 1/16 in 25 of the 50 patients (50%) and in 20 of the control group (40%). No higher antibody titre was found in the control group. In conclusion, despite the emerging literature on a possible relationship between T. gondii infection and neurological disease, and the high anti-T. gondii seropositivity found in our PD patients, we did not detect any statistically significant association between T. gondii and idiopathic PD.Öğe Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients(Korean Soc Parasitology, Seoul Natl Univ Coll Medi, 2008) Karaman, Ulku; Celik, Tuncay; Kiran, Tugba Raika; Colak, Cemil; Daldal, Nilgun UlfetThe aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 +/- 543.8 in optical density (mean +/- SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.Öğe Toxocara Seroprevalence in Patients with Idiopathic Parkinson's Disease: Chance Association or Coincidence?(Hindawi Ltd, 2013) Celik, Tuncay; Kaplan, Yuksel; Atas, Eser; Oztuna, Derya; Berilgen, SaidMost cases of idiopathic Parkinson disease (IPD) are believed to be due to a combination of genetic and environmental factors. The purpose of this study is to investigate the relationship between toxocariasis and Parkinson disease (PD). Patients were selected from people who were admitted to the Movement Disorders Branch, Neurology Department of Elazig University Faculty of Medicine Elazig, Turkey. We studied specific IgG antibodies against Toxocara canis (T. canis) in 50 patients with idiopathic Parkinson and 50 healthy volunteers. We investigated the clinical history of three patients infected with T. canis. We also studied specific IgG antibodies against Toxoplasma gondii in these groups. Antibodies anti-Toxocara canis were found in 3 idiopathic PD (6%) (P = 0.121) and antibody titer was not found in control. A patient had history of the presence of dog in current dog ownership. We did not detect any statistically significant association between T. canis and IPD. But, we believe that further comprehensive studies are required for understanding whether there is a causal relation between toxocariasis and PD. We didn't find possible association between Toxoplasma gondii and IPD (P = 0.617).
