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    The effects of fibroblast growth factor-2 and ozone therapy on acute kidney injury in renal ischemia/reperfusion injury
    (Parlar Scientific Publications, 2020) Bahar L.; Gul M.; Resitoglu B.; Celik Y.; Erturk S.E.; Gul S.
    Renal ischemia/reperfusion (I/R) injury is the most common risk factor for AKI. The study aimed to investigate the effects of FGF-2 and ozone applications on the kidneys of rats with hypoxic-ischemia. Six groups were formed with seven pups in each: sham control, ischemia-reperfusion (I/R), FGF-2(10-1/ml); FGF-2(20 ul/ml), ozone (25 mg/kg), and ozone (50 mg/kg) groups. After the tissue processing and staining of the kidney samples, the renal injury was scored and data were analyzed. Manifestations of collapse and sclerotic changes in the glomeruli, observations of collapse in the Bowman's space, ex¬ cessive accumulation in the ultrafiltrate and dilata¬ tion was noted in the I/R group. The average diame¬ ter of the glomeruli and the scores of injury were sig¬ nificantly different between the I/R and FGF20 groups and the I/R and Ozone 50 groups (p<0.05). The histopathologic assessment showed that the treatment with FGF-2 or ozone had renoprotective effects against renal damage caused by I/R in a dose-dependent manner. This study may discover a new therapeutic strategy for the treatment of AKI based on specified pathogenesis. This study found the FGF-2 and ozone applications to be beneficial for the treatment of AKI at the cellular level with certain doses. © 2020 Parlar Scientific Publications. All rights reserved.