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    An impulse control disorder case with penile fracture and trichotillomania
    (Tubitak Scientific & Technological Research Council Turkey, 2007) Cumurcu, Birguel Elbozan; Kaya, Burhanettin; Celikel, Feryal Cam; Soylu, Ahmet; Erdemir, Fikret
    Penile fractures are classically described as presenting with rapid detumescence of an erection associated with blunt trauma. This clinical finding is due to a tear in the tunica albuginea surrounding the corpora cavernosum. In this study, we report and discuss a case of trichotillomania and penile bending impulse resulting in penile fracture, which was operated in the urology clinic. The possible psychological and psychiatric problems underlying the impulsive behavior are discussed, and the value of a psychiatric evaluation is emphasized.
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    Influence of ABCB1 polymorphisms and serum concentrations on venlafaxine response in patients with major depressive disorder
    (Taylor & Francis Ltd, 2017) Ozbey, Gul; Celikel, Feryal Cam; Cumurcu, Birgul Elbozan; Kan, Derya; Yucel, Berna; Hasbek, Ekrem; Percin, Ferda
    Background: The pharmacokinetics and the pharmacodynamics of antidepressants show large inter-individual variations which result in unpredictable clinical responses.Aim: The aim of the study was to examine the effect of ABCB1 polymorphisms and the serum concentrations on the efficacy and tolerability of venlafaxine in patients with major depressive disorder (MDD).Methods: Fifty-two outpatients who met the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria for MDD were recruited for the study. The severity of depression was assessed using the 17-item Hamilton Rating Scale for Depression scale (HDRS17) and tolerability was assessed based on a query regarding side-effects for 6 weeks. The ABCB1 C3435T/A and G2677T/A polymorphisms were genotyped by PCR/RFLP and steady-state serum venlafaxine concentrations were measured by high-performance liquid chromatography.Results: Patients with the TT genotype for the C3435T and the TT/TA genotype for the G2677T/A polymorphism showed significantly higher frequencies in venlafaxine-induced akathisia. This relationship was not observed for efficacy. As regards serum venlafaxine concentrations, patient groups showed no significant differences in efficacy and tolerability.Conclusion: The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia.
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    Normative data and factorial structure of the Turkish version of the Junior Temperament and Character Inventory-Revised
    (Taylor & Francis Ltd, 2017) Kose, Samet; Celikel, Feryal Cam; Akin, Ercan; Kaya, Cahit; Cumurcu, Birgul Elbozan; Etikan, Ilker; Cloninger, C. Robert
    Objective: Junior Temperament and Character Inventory (J-TCI) was developed by Luby, Svrakic, McCallum, Przybeck, and Cloninger based on Cloninger's biopsychosocial model to assess temperament and character dimensions in children and adolescents. Methods: The Turkish version of J-TCI-Revised (J-TCI-R) was administered to 1129 elementary and middle-school (male/female, 546/583) students. Internal consistency reliabilities were measured by Cronbach's alpha; test-retest was assessed across one month. Results: Cronbach's alphas for the subscales of J-TCI-R ranged from 0.60 to 0.75 for temperament and character subscales, which were comparable to US and other populations. The correlations between baseline and one month after administration of J-TCI-R were highly and statistically significant (r = 0.578-0.674 for scales and 0.366-0.582 for subscales) (n = 795). Factor analysis results using Eigenvalue greater than one rule indicated three out of four factors for temperament scales and one out of two factors for character subscales which were similar to findings from the other countries. When all of the subscales were subjected to factor analysis, four out of six factors were retained. To our knowledge, this is the first study analysing psychometric properties and factorial construct of the J-TCI-R. Conclusions: The internal reliability coefficients and test-retest indicated a good stability of scores over time and the factorial structure was consistent with Cloninger's model of personality. The reliability and validity of the Turkish version of the TCI is therefore supported.
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    Tongue edema and tongue paresthesia during immediate-release venlafaxine treatment
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2009) Cumurcu, Birguel Elbozan; Ozbey, Guel; Celikel, Feryal Cam; Celikel, Serhat; Hasbek, Ekrem; Sezer, Engin
    The patient was a 34-year-old woman who was diagnosed with major depressive disorder and was stalled on venlafaxine 37.5 mg/day (immediate-release tablet formula). On the third day of venlafaxine treatment, she has developed tongue edema and paresthesia and difficulty in swallowing 10-15 minutes after ingestion of the pill. The symptoms resolved throughout the day. On the 4th day of the treatment, the same symptoms appeared once again. The case was diagnosed as hypersensitivity reaction. To our knowledge, this is the first case report presented with angioedema induced by venlataxine, which is in line with the World Health Organization's 'unexpected adverse drug reactions' definition; we reported these adverse events to Turkey Farmacovigilance Center (TUFAM) by means of the 'adverse effects reporting form'. Spontaneous reporting of the unexpected adverse events to TUFAM are necessary for the safe use of the prescribed drugs. (Anatolian Journal of Psychiatry 2009; 10:246-248)